Basic Information:

  VIRBase ID:  

VHID00504520

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          NFKB1:  NM_001319226     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	NFKB1
miRBase Accession/Entrez ID	MIMAT0001581	4790
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	CVID12//EBP-1//KBF1//NF-kappa-B1//NF-kappaB//NF-kappabeta//NF-kB//NF-kB1//NFkappaB//NFKB-p105//NFKB-p50

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	NFKB1	chr4:103523438(+) A-I      intronic chr4:103523449(+) A-I      intronic chr4:103523459(+) A-I      intronic chr4:103493795(+) A-I      intronic chr4:103492977(+) A-I      intronic chr4:103492953(+) A-I      intronic chr4:103491504(+) A-I      intronic chr4:103491499(+) A-I      intronic chr4:103491467(+) A-I      intronic chr4:103465253(+) A-I      intronic chr4:103524504(+) A-I      intronic chr4:103524508(+) A-I      intronic chr4:103523433(+) A-I      intronic chr4:103524404(+) A-I      intronic chr4:103524369(+) A-I      intronic chr4:103524359(+) A-I      intronic chr4:103524347(+) A-I      intronic chr4:103524330(+) A-I      intronic chr4:103523603(+) A-I      intronic chr4:103481082(+) A-I      intronic chr4:103479949(+) A-I      intronic chr4:103479851(+) A-I      intronic chr4:103433632(+) A-I      intronic chr4:103433605(+) A-I      intronic chr4:103432839(+) A-I      intronic chr4:103432582(+) A-I      intronic chr4:103480975(+) A-I      intronic chr4:103524467(+) A-I      intronic chr4:103433606(+) A-I      intronic chr4:103479909(+) A-I      intronic chr4:103523426(+) A-I      intronic chr4:103432753(+) A-I      intronic chr4:103432590(+) A-I      intronic chr4:103432816(+) A-I      intronic chr4:103523576(+) A-I      intronic chr4:103432576(+) A-I      intronic chr4:103479947(+) A-I      intronic chr4:103432560(+) A-I      intronic chr4:103524281(+) A-I      intronic chr4:103432739(+) A-I      intronic chr4:103479811(+) A-I      intronic chr4:103433631(+) A-I      intronic chr4:103433610(+) A-I      intronic chr4:103479934(+) A-I      intronic chr4:103479920(+) A-I      intronic chr4:103480821(+) A-I      intronic chr4:103433724(+) A-I      intronic chr4:103480827(+) A-I      intronic chr4:103481040(+) A-I      intronic chr4:103435067(+) A-I      intronic chr4:103480989(+) A-I      intronic chr4:103523432(+) A-I      intronic chr4:103481050(+) A-I      intronic chr4:103479831(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	NFKB1	chr4:103480975(+) A-I intron -    22327324 chr4:103491632(+) A-G intron -    22484847 chr4:103491738(+) A-G intron -    22484847 chr4:103493713(+) A-G intron -    22484847 chr4:103493734(+) A-G intron -    22484847 chr4:103432560(+) A-G intron -    22484847 chr4:103432576(+) A-G intron -    22484847 chr4:103432590(+) A-G intron -    22484847 chr4:103432646(+) A-G intron -    22484847 chr4:103432650(+) A-G intron -    22484847 chr4:103432753(+) A-G intron -    22484847 chr4:103432816(+) A-G intron -    22484847 chr4:103433557(+) A-G intron -    22484847 chr4:103433606(+) A-G intron -    22484847 chr4:103433610(+) A-G intron -    22484847 chr4:103433618(+) A-G intron -    22484847 chr4:103433623(+) A-G intron -    22484847 chr4:103433631(+) A-G intron -    22484847 chr4:103435067(+) A-G intron -    22484847 chr4:103479811(+) A-G intron -    22484847 chr4:103479831(+) A-G intron -    22484847 chr4:103479877(+) A-G intron -    22484847 chr4:103479920(+) A-G intron -    22484847 chr4:103479934(+) A-G intron -    22484847 chr4:103479937(+) A-G intron -    22484847 chr4:103480975(+) A-G intron -    22484847 chr4:103480989(+) A-G intron -    22484847 chr4:103523426(+) A-G intron -    22484847 chr4:103523430(+) A-G intron -    22484847 chr4:103523576(+) A-G intron -    22484847 chr4:103523638(+) A-G intron -    22484847 chr4:103524281(+) A-G intron -    22484847 chr4:103524467(+) A-G intron -    22484847 chr4:103530591(+) A-T intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	NFKB1	chr4:103422502-103422503(+) m6A 5'UTR       24981863 chr4:103517354-103517355(+) m6A CDS//exon       26404942 chr4:103517363-103517364(+) m6A CDS//exon       26404942 chr4:103517386-103517387(+) m6A CDS//exon       26404942 chr4:103517461-103517462(+) m6A CDS//exon       26404942 chr4:103537602-103537603(+) m6A CDS       24284625 chr4:103537634-103537635(+) m6A CDS       24284625//24981863//26404942 chr4:103537648-103537649(+) m6A CDS       24284625//24981863//26404942 chr4:103537729-103537730(+) m6A CDS       24284625//24981863//26404942//22608085 chr4:103537779-103537780(+) m6A 3'UTR       24284625//24981863//26404942//22608085 chr4:103537815-103537816(+) m6A 3'UTR       24284625//24981863//26404942//22608085 chr4:103537886-103537887(+) m6A 3'UTR       24284625//26404942

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	NFKB1	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleus HeLa-S3 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: NFKB1

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.