Detail Information

Basic Information:


  VIRBase ID:  

VHID00504460

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           NDUFA7:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p NDUFA7
miRBase
Accession/Entrez ID		 MIMAT0001581 4701
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - B14.5a//CI-B14.5a

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR NDUFA7
chr19:8377502(-) A-I      intronic
chr19:8377497(-) A-I      intronic
chr19:8377463(-) A-I      intronic
chr19:8377462(-) A-I      intronic
chr19:8377436(-) A-I      intronic
chr19:8382640(-) A-I      intronic
chr19:8384899(-) A-I      intronic
chr19:8384763(-) A-I      intronic
chr19:8383506(-) A-I      intronic
chr19:8383395(-) A-I      intronic
chr19:8383366(-) A-I      intronic
chr19:8383267(-) A-I      intronic
chr19:8383228(-) A-I      intronic
chr19:8383227(-) A-I      intronic
chr19:8383222(-) A-I      intronic
chr19:8383209(-) A-I      intronic
chr19:8383207(-) A-I      intronic
chr19:8383017(-) A-I      intronic
chr19:8383016(-) A-I      intronic
chr19:8382838(-) A-I      intronic
chr19:8382391(-) A-I      intronic
chr19:8382301(-) A-I      intronic
chr19:8382225(-) A-I      intronic
chr19:8381170(-) A-I      intronic
chr19:8381147(-) A-I      intronic
chr19:8380964(-) A-I      intronic
chr19:8380950(-) A-I      intronic
chr19:8380854(-) A-I      intronic
chr19:8380788(-) A-I      intronic
chr19:8379697(-) A-I      intronic
chr19:8379681(-) A-I      intronic
chr19:8379675(-) A-I      intronic
chr19:8379672(-) A-I      intronic
chr19:8379616(-) A-I      intronic
chr19:8379553(-) A-I      intronic
chr19:8378319(-) A-I      intronic
chr19:8378286(-) A-I      intronic
chr19:8378253(-) A-I      intronic
chr19:8378060(-) A-I      intronic
chr19:8377722(-) A-I      intronic
chr19:8377718(-) A-I      intronic
chr19:8377717(-) A-I      intronic
chr19:8377716(-) A-I      intronic
chr19:8377687(-) A-I      intronic
chr19:8377580(-) A-I      intronic
chr19:8379736(-) A-I      intronic
chr19:8383095(-) A-I      intronic
chr19:8383173(-) A-I      intronic
chr19:8384909(-) A-I      intronic
chr19:8383233(-) A-I      intronic
chr19:8384827(-) A-I      intronic
chr19:8384925(-) A-I      intronic
chr19:8384790(-) A-I      intronic
chr19:8383839(-) A-I      intronic
chr19:8384967(-) A-I      intronic
chr19:8384738(-) A-I      intronic
chr19:8384939(-) A-I      intronic
chr19:8384762(-) A-I      intronic
chr19:8384858(-) A-I      intronic
chr19:8378247(-) A-I      intronic
chr19:8384802(-) A-I      intronic
chr19:8384994(-) A-I      intronic
chr19:8382341(-) A-I      intronic
chr19:8383198(-) A-I      intronic
chr19:8384734(-) A-I      intronic
chr19:8384894(-) A-I      intronic
chr19:8382699(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED NDUFA7
chr19:8384762(-) A-G intron -    22484847
chr19:8384790(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase NDUFA7
chr19:8375391-8375392(-) m6A exon//intron       27773535
chr19:8375424-8375425(-) m6A exon//intron       27773535
chr19:8375433-8375434(-) m6A exon//intron       27773535
chr19:8376218-8376219(-) m6A 3'UTR//intron       27773535
chr19:8376253-8376254(-) m6A 3'UTR//exon//intron       27773535
chr19:8376404-8376405(-) m6A 3'UTR//CDS//exon//intron       27773535
chr19:8381527-8381528(-) m6A CDS//exon//intron       24284625//24981863//27773535//27371828//22575960
chr19:8386204-8386205(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//22575960//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate NDUFA7
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: NDUFA7

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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