Basic Information:

  VIRBase ID:  

VHID00504404

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          MYH10:  NM_005964     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	MYH10
miRBase Accession/Entrez ID	MIMAT0001581	4628
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	NMMHC-IIB//NMMHCB

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MYH10	chr17:8521880(-) A-I      intronic chr17:8441721(-) A-I      intronic chr17:8443482(-) A-I      intronic chr17:8523128(-) A-I      intronic chr17:8481598(-) A-I      intronic chr17:8441684(-) A-I      intronic chr17:8528204(-) A-I      intronic chr17:8439893(-) A-I      intronic chr17:8439925(-) A-I      intronic chr17:8439937(-) A-I      intronic chr17:8401352(-) A-I      intronic chr17:8481628(-) A-I      intronic chr17:8439951(-) A-I      intronic chr17:8401357(-) A-I      intronic chr17:8401362(-) A-I      intronic chr17:8401412(-) A-I      intronic chr17:8481618(-) A-I      intronic chr17:8401425(-) A-I      intronic chr17:8481633(-) A-I      intronic chr17:8521821(-) A-I      intronic chr17:8521829(-) A-I      intronic chr17:8440109(-) A-I      intronic chr17:8443446(-) A-I      intronic chr17:8480917(-) A-I      intronic chr17:8480935(-) A-I      intronic chr17:8440041(-) A-I      intronic chr17:8440113(-) A-I      intronic chr17:8481590(-) A-I      intronic chr17:8481591(-) A-I      intronic chr17:8481608(-) A-I      intronic chr17:8481623(-) A-I      intronic chr17:8482545(-) A-I      intronic chr17:8482521(-) A-I      intronic chr17:8481681(-) A-I      intronic chr17:8481672(-) A-I      intronic chr17:8411533(-) A-I      intronic chr17:8411542(-) A-I      intronic chr17:8411561(-) A-I      intronic chr17:8411575(-) A-I      intronic chr17:8439995(-) A-I      intronic chr17:8481657(-) A-I      intronic chr17:8481653(-) A-I      intronic chr17:8481646(-) A-I      intronic chr17:8440005(-) A-I      intronic chr17:8411207(-) A-I      intronic chr17:8529639(-) A-I      intronic chr17:8521594(-) A-I      intronic chr17:8518582(-) A-I      intronic chr17:8517872(-) A-I      intronic chr17:8517810(-) A-I      intronic chr17:8517801(-) A-I      intronic chr17:8517797(-) A-I      intronic chr17:8517740(-) A-I      intronic chr17:8517722(-) A-I      intronic chr17:8508943(-) A-I      intronic chr17:8483400(-) A-I      intronic chr17:8483376(-) A-I      intronic chr17:8440073(-) A-I      intronic chr17:8440078(-) A-I      intronic chr17:8483369(-) A-I      intronic chr17:8483363(-) A-I      intronic chr17:8482551(-) A-I      intronic chr17:8392896(-) A-I      intronic chr17:8421566(-) A-I      intronic chr17:8528363(-) A-I      intronic chr17:8441661(-) A-I      intronic chr17:8421616(-) A-I      intronic chr17:8518449(-) A-I      intronic chr17:8523196(-) A-I      intronic chr17:8529071(-) A-I      intronic chr17:8481701(-) A-I      intronic chr17:8429267(-) A-I      intronic chr17:8521839(-) A-I      intronic chr17:8528919(-) A-I      intronic chr17:8528206(-) A-I      intronic chr17:8419134(-) A-I      intronic chr17:8483412(-) A-I      intronic chr17:8529825(-) A-I      intronic chr17:8440111(-) A-I      intronic chr17:8401507(-) A-I      intronic chr17:8517891(-) A-I      intronic chr17:8482457(-) A-I      intronic chr17:8401438(-) A-I      intronic chr17:8529072(-) A-I      intronic chr17:8508807(-) A-I      intronic chr17:8419141(-) A-I      intronic chr17:8508819(-) A-I      intronic chr17:8421485(-) A-I      intronic chr17:8443350(-) A-I      intronic chr17:8411693(-) A-I      intronic chr17:8427587(-) A-I      intronic chr17:8411671(-) A-I      intronic chr17:8528908(-) A-I      intronic chr17:8443472(-) A-I      intronic chr17:8483388(-) A-I      intronic chr17:8521696(-) A-I      intronic chr17:8420433(-) A-I      intronic chr17:8518446(-) A-I      intronic chr17:8481765(-) A-I      intronic chr17:8411640(-) A-I      intronic chr17:8411620(-) A-I      intronic chr17:8518448(-) A-I      intronic chr17:8528350(-) A-I      intronic chr17:8481636(-) A-I      intronic chr17:8419157(-) A-I      intronic chr17:8406435(-) A-I      intronic chr17:8420212(-) A-I      intronic chr17:8443436(-) A-I      intronic chr17:8528375(-) A-I      intronic chr17:8414834(-) A-I      intronic chr17:8421518(-) A-I      intronic chr17:8528421(-) A-I      intronic chr17:8517884(-) A-I      intronic chr17:8508967(-) A-I      intronic chr17:8528197(-) A-I      intronic chr17:8420426(-) A-I      intronic chr17:8521830(-) A-I      intronic chr17:8493812(-) A-I      intronic chr17:8482473(-) A-I      intronic chr17:8399093(-) A-I      intronic chr17:8401483(-) A-I      intronic chr17:8518590(-) A-I      intronic chr17:8421519(-) A-I      intronic chr17:8508950(-) A-I      intronic chr17:8483362(-) A-I      intronic chr17:8528447(-) A-I      intronic chr17:8517709(-) A-I      intronic chr17:8525366(-) A-I      intronic chr17:8421612(-) A-I      intronic chr17:8508798(-) A-I      intronic chr17:8411166(-) A-I      intronic chr17:8528218(-) A-I      intronic chr17:8521838(-) A-I      intronic chr17:8521634(-) A-I      intronic chr17:8505646(-) A-I      intronic chr17:8401476(-) A-I      intronic chr17:8481799(-) A-I      intronic chr17:8401482(-) A-I      intronic chr17:8421603(-) A-I      intronic chr17:8482485(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MYH10	chr17:8402098(-) T-C intron -    22484847 chr17:8420467(-) A-T intron -    22484847 chr17:8443472(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MYH10	chr17:8377547-8377548(-) m6A 3'UTR       27773535 chr17:8377557-8377558(-) m6A 3'UTR       27773535 chr17:8377635-8377636(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr17:8377652-8377653(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr17:8377696-8377697(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr17:8377720-8377721(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr17:8377802-8377803(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr17:8377808-8377809(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr17:8377871-8377872(-) m6A 3'UTR       24284625 chr17:8377970-8377971(-) m6A 3'UTR       24284625//22608085 chr17:8377986-8377987(-) m6A 3'UTR       24284625//24981863//22608085 chr17:8378011-8378012(-) m6A 3'UTR       24284625//24981863//22575960//22608085 chr17:8378048-8378049(-) m6A 3'UTR       24284625//24981863//22575960//22608085 chr17:8378063-8378064(-) m6A 3'UTR       24284625//24981863//22575960//22608085 chr17:8378138-8378139(-) m6A 3'UTR       24284625//24981863//22575960//22608085 chr17:8378298-8378299(-) m6A 3'UTR       24284625//24981863//27371828//22608085 chr17:8378349-8378350(-) m6A 3'UTR       24284625//24981863//27371828//27773536//22575960//22608085 chr17:8378369-8378370(-) m6A 3'UTR       24284625//24981863//27371828//22575960//22608085 chr17:8378458-8378459(-) m6A 3'UTR       24284625//24209618//24981863//27773535//27371828//22575960//22608085 chr17:8378554-8378555(-) Tm 3'UTR       - chr17:8378593-8378594(-) m6A 3'UTR       24284625//24209618//24981863//27773535//27371828//22608085 chr17:8378651-8378652(-) m6A 3'UTR       24284625//24209618//24981863//27773535//27371828//22608085 chr17:8378658-8378659(-) m6A 3'UTR       24284625//24209618//24981863//27773535//27371828//22608085 chr17:8378668-8378669(-) m6A 3'UTR       24284625//24209618//24981863//27773535//27371828//22608085 chr17:8378730-8378731(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr17:8378822-8378823(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr17:8378834-8378835(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr17:8378844-8378845(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr17:8378857-8378858(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr17:8378904-8378905(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr17:8378917-8378918(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr17:8378928-8378929(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr17:8378962-8378963(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr17:8379086-8379087(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr17:8379162-8379163(-) m6A CDS       24284625//25456834//24981863//28052920//27773535//27371828//27773536//22608085 chr17:8380202-8380203(-) m6A CDS       24284625//27773535//27371828//27773536//22575960 chr17:8380261-8380262(-) m6A CDS       24284625//24209618//27773535//27371828//27773536 chr17:8380273-8380274(-) m6A CDS       24284625//24209618//27773535//27371828//27773536 chr17:8381657-8381658(-) Cm CDS//exon       - chr17:8381671-8381672(-) m6A CDS//exon       24209618//24981863//27773535//27371828//22575960 chr17:8383522-8383523(-) m6A CDS//exon       24209618//24981863//27773535//27371828//27773536//22575960 chr17:8383550-8383551(-) m6A CDS//exon       24209618//24981863//27773535//27371828//27773536//22575960 chr17:8383631-8383632(-) m6A CDS//exon       24284625//24981863//27773535//27371828//27773536//22575960 chr17:8383730-8383731(-) m6A CDS//exon       24284625//24981863//27773535//27371828//27773536//22575960 chr17:8384725-8384726(-) m6A CDS//exon       27773535//27371828//27773536 chr17:8390793-8390794(-) m6A CDS       24284625//24209618//24981863//27773535//27371828 chr17:8390820-8390821(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//27773536 chr17:8390829-8390830(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//27773536 chr17:8390873-8390874(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//27773536//22575960 chr17:8393660-8393661(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//27773536//22575960 chr17:8393704-8393705(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//27773536//22575960 chr17:8393712-8393713(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//27773536//22575960 chr17:8393786-8393787(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//27773536//22575960 chr17:8393812-8393813(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//27773536//22575960 chr17:8393861-8393862(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr17:8395648-8395649(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr17:8395657-8395658(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr17:8395675-8395676(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr17:8395745-8395746(-) m6A CDS       24284625//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr17:8395777-8395778(-) m6A CDS       24284625//24981863//28052920//27773535//27371828//27773536//22608085 chr17:8396148-8396149(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27773536 chr17:8396154-8396155(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27773536 chr17:8396190-8396191(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//27773536 chr17:8396197-8396198(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//27773536 chr17:8396207-8396208(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//27773536 chr17:8396272-8396273(-) m1A CDS//exon       26863196 chr17:8396283-8396284(-) m1A CDS//exon       26863196 chr17:8396302-8396303(-) m6A CDS//exon       24284625//24209618//24981863//28052920//27773535//27371828//27773536 chr17:8397084-8397085(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//27773536 chr17:8397129-8397130(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//27773536 chr17:8397168-8397169(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//27773536 chr17:8397173-8397174(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//27773536 chr17:8397184-8397185(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//27773536 chr17:8397208-8397209(-) m6A exon//intron       24284625//24209618//24981863//27773535//27371828 chr17:8398513-8398514(-) m1A CDS       26863196 chr17:8398524-8398525(-) m1A CDS       26863196 chr17:8402679-8402680(-) m1A CDS       26863196 chr17:8402688-8402689(-) Am CDS       - chr17:8402754-8402755(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22575960 chr17:8402771-8402772(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22575960 chr17:8404155-8404156(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22575960 chr17:8404194-8404195(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22575960 chr17:8404200-8404201(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22575960 chr17:8404207-8404208(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22575960 chr17:8404228-8404229(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22575960//22608085 chr17:8404235-8404236(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22575960//22608085 chr17:8404275-8404276(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr17:8408016-8408017(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr17:8408038-8408039(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr17:8408047-8408048(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr17:8408059-8408060(-) Cm CDS       - chr17:8408060-8408061(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr17:8408076-8408077(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr17:8408089-8408090(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr17:8408113-8408114(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr17:8408140-8408141(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr17:8408151-8408152(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr17:8408197-8408198(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22608085 chr17:8408210-8408211(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22608085 chr17:8409378-8409379(-) m6A exon//intron       - chr17:8409720-8409721(-) Cm CDS//exon       - chr17:8409722-8409723(-) m6A CDS//exon       24284625//25456834//24981863//27773535//27371828//27773536//22575960//22608085 chr17:8409751-8409752(-) m6A CDS//exon       24284625//25456834//24981863//27773535//27371828//27773536//22608085 chr17:8409772-8409773(-) m6A CDS//exon       24284625//25456834//24981863//27773535//27371828//27773536//22608085 chr17:8409783-8409784(-) m6A CDS//exon       24284625//25456834//24981863//27773535//27371828//27773536//22608085 chr17:8411921-8411922(-) m6A CDS//exon       24981863//27773535//27371828 chr17:8411986-8411987(-) m6A CDS//exon       24981863//27773535//27371828//27773536 chr17:8413151-8413152(-) m6A CDS//exon       24981863//27773535//27371828//27773536 chr17:8413182-8413183(-) Am CDS//exon       - chr17:8413255-8413256(-) m6A CDS       24981863//27773535//27371828 chr17:8415814-8415815(-) m6A CDS       24981863//27773535//27371828 chr17:8415829-8415830(-) m1A CDS       26863196 chr17:8415891-8415892(-) m6A CDS       24209618//24981863//27773535//27371828 chr17:8415929-8415930(-) m6A CDS       24209618//24981863//27773535//27371828 chr17:8415945-8415946(-) m6A CDS       24209618//24981863//28052920//27773535//27371828 chr17:8416937-8416938(-) Am CDS       - chr17:8416948-8416949(-) m6A CDS       24981863//28052920//27773535//27371828//22575960 chr17:8422076-8422077(-) Cm CDS       - chr17:8438733-8438734(-) m6A CDS       22575960 chr17:8438778-8438779(-) m6A CDS       22575960 chr17:8438814-8438815(-) m6A CDS       24981863//22575960 chr17:8439112-8439113(-) m6A CDS       24981863//22575960 chr17:8439129-8439130(-) m6A CDS       22575960 chr17:8439168-8439169(-) m6A CDS       22575960 chr17:8439182-8439183(-) m6A CDS       22575960 chr17:8526325-8526326(-) m6A CDS       24284625//24981863//27773535//27371828//22608085 chr17:8526473-8526474(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr17:8526514-8526515(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr17:8526546-8526547(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr17:8526551-8526552(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr17:8526745-8526746(-) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//27371828//22575960//22608085 chr17:8526792-8526793(-) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//27371828//22575960//22608085 chr17:8526801-8526802(-) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//27371828//22575960//22608085 chr17:8534035-8534036(-) m6A 5'UTR       25456834//24981863//27371828//22575960//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	MYH10	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: MYH10

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.