Basic Information:

  VIRBase ID:  

VHID00504142

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          SMAD3:  NM_005902     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	SMAD3
miRBase Accession/Entrez ID	MIMAT0001581	4088
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	HSPC193//HsT17436//JV15-2//LDS1C//LDS3//MADH3

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SMAD3	chr15:67452930(+) A-I      intronic chr15:67452962(+) A-I      intronic chr15:67358882(+) A-I      intronic chr15:67451670(+) A-I      intronic chr15:67451671(+) A-I      intronic chr15:67452947(+) A-I      intronic chr15:67394254(+) A-I      intronic chr15:67451683(+) A-I      intronic chr15:67451672(+) A-I      intronic chr15:67452950(+) A-I      intronic chr15:67394253(+) A-I      intronic chr15:67362173(+) A-I      intronic chr15:67403460(+) A-I      intronic chr15:67451592(+) A-I      intronic chr15:67451581(+) A-I      intronic chr15:67451570(+) A-I      intronic chr15:67416609(+) A-I      intronic chr15:67416603(+) A-I      intronic chr15:67416411(+) A-I      intronic chr15:67416365(+) A-I      intronic chr15:67416349(+) A-I      intronic chr15:67415758(+) A-I      intronic chr15:67389768(+) A-I      intronic chr15:67389769(+) A-I      intronic chr15:67415506(+) A-I      intronic chr15:67415445(+) A-I      intronic chr15:67415389(+) A-I      intronic chr15:67367127(+) A-I      intronic chr15:67452943(+) A-I      intronic chr15:67456585(+) A-I      intronic chr15:67412396(+) A-I      intronic chr15:67456466(+) A-I      intronic chr15:67389771(+) A-I      intronic chr15:67368181(+) A-I      intronic chr15:67456616(+) A-I      intronic chr15:67456372(+) A-I      intronic chr15:67412356(+) A-I      intronic chr15:67456581(+) A-I      intronic chr15:67405627(+) A-I      intronic chr15:67366170(+) A-I      intronic chr15:67456546(+) A-I      intronic chr15:67392319(+) A-I      intronic chr15:67412179(+) A-I      intronic chr15:67456542(+) A-I      intronic chr15:67456516(+) A-I      intronic chr15:67456471(+) A-I      intronic chr15:67456470(+) A-I      intronic chr15:67368088(+) A-I      intronic chr15:67366112(+) A-I      intronic chr15:67389693(+) A-I      intronic chr15:67367131(+) A-I      intronic chr15:67367102(+) A-I      intronic chr15:67367157(+) A-I      intronic chr15:67455501(+) A-I      intronic chr15:67366211(+) A-I      intronic chr15:67366195(+) A-I      intronic chr15:67366149(+) A-I      intronic chr15:67366142(+) A-I      intronic chr15:67366113(+) A-I      intronic chr15:67410310(+) A-I      intronic chr15:67455495(+) A-I      intronic chr15:67368114(+) A-I      intronic chr15:67455405(+) A-I      intronic chr15:67455376(+) A-I      intronic chr15:67453054(+) A-I      intronic chr15:67412228(+) A-I      intronic chr15:67453053(+) A-I      intronic chr15:67453034(+) A-I      intronic chr15:67453018(+) A-I      intronic chr15:67415675(+) A-I      intronic chr15:67368202(+) A-I      intronic chr15:67366106(+) A-I      intronic chr15:67366069(+) A-I      intronic chr15:67366061(+) A-I      intronic chr15:67453015(+) A-I      intronic chr15:67415386(+) A-I      intronic chr15:67453011(+) A-I      intronic chr15:67452994(+) A-I      intronic chr15:67452958(+) A-I      intronic chr15:67452927(+) A-I      intronic chr15:67452894(+) A-I      intronic chr15:67452891(+) A-I      intronic chr15:67452855(+) A-I      intronic chr15:67452839(+) A-I      intronic chr15:67415717(+) A-I      intronic chr15:67451509(+) A-I      intronic chr15:67451652(+) A-I      intronic chr15:67451609(+) A-I      intronic chr15:67451606(+) A-I      intronic chr15:67456143(+) A-I      intronic chr15:67410283(+) A-I      intronic chr15:67412332(+) A-I      intronic chr15:67451478(+) A-I      intronic chr15:67412397(+) A-I      intronic chr15:67367047(+) A-I      intronic chr15:67368106(+) A-I      intronic chr15:67363921(+) A-I      intronic chr15:67455555(+) A-I      intronic chr15:67416500(+) A-I      intronic chr15:67455512(+) A-I      intronic chr15:67367189(+) A-I      intronic chr15:67415375(+) A-I      intronic chr15:67415739(+) A-I      intronic chr15:67415579(+) A-I      intronic chr15:67443457(+) A-I      intronic chr15:67415685(+) A-I      intronic chr15:67368133(+) A-I      intronic chr15:67368119(+) A-I      intronic chr15:67452882(+) A-I      intronic chr15:67368174(+) A-I      intronic chr15:67367193(+) A-I      intronic chr15:67416427(+) A-I      intronic chr15:67366220(+) A-I      intronic chr15:67416492(+) A-I      intronic chr15:67362144(+) A-I      intronic chr15:67367097(+) A-I      intronic chr15:67476581(+) A-I      intronic chr15:67368185(+) A-I      intronic chr15:67415373(+) A-I      intronic chr15:67415687(+) A-I      intronic chr15:67410410(+) A-I      intronic chr15:67362114(+) A-I      intronic chr15:67421012(+) A-I      intronic chr15:67410364(+) A-I      intronic chr15:67455333(+) A-I      intronic chr15:67368100(+) A-I      intronic chr15:67416601(+) A-I      intronic chr15:67410351(+) A-I      intronic chr15:67452978(+) A-I      intronic chr15:67415787(+) A-I      intronic chr15:67405710(+) A-I      intronic chr15:67455441(+) A-I      intronic chr15:67366158(+) A-I      intronic chr15:67368198(+) A-I      intronic chr15:67455332(+) A-I      intronic chr15:67368203(+) A-I      intronic chr15:67363962(+) A-I      intronic chr15:67415671(+) A-I      intronic chr15:67415676(+) A-I      intronic chr15:67405711(+) A-I      intronic chr15:67405702(+) A-I      intronic chr15:67368210(+) A-I      intronic chr15:67416395(+) A-I      intronic chr15:67416561(+) A-I      intronic chr15:67415408(+) A-I      intronic chr15:67415680(+) A-I      intronic chr15:67368146(+) A-I      intronic chr15:67410342(+) A-I      intronic chr15:67416562(+) A-I      intronic chr15:67456395(+) A-I      intronic chr15:67362119(+) A-I      intronic chr15:67478497(+) A-I      intronic chr15:67368044(+) A-I      intronic chr15:67452949(+) A-I      intronic chr15:67363875(+) A-I      intronic chr15:67483483(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SMAD3	chr15:67368146(+) A-G intron -    22484847 chr15:67415675(+) A-G intron -    22484847 chr15:67451478(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SMAD3	chr15:67356224-67356225(+) m6A 5'UTR       24981863 chr15:67356275-67356276(+) m6A 5'UTR       24981863 chr15:67358549-67358550(+) m1A CDS//intron       26863196//26863410 chr15:67358614-67358615(+) m6A CDS//intron       24284625//24981863//26404942 chr15:67390932-67390933(+) m6A 5'UTR//intron       24284625 chr15:67418223-67418224(+) m6A 5'UTR//intron       24981863 chr15:67457312-67457313(+) m6A 5'UTR//CDS//exon       24284625 chr15:67457419-67457420(+) m6A CDS//exon       24284625//24981863 chr15:67457677-67457678(+) m6A CDS//exon       24284625//24981863 chr15:67459093-67459094(+) m6A 5'UTR//intron       24284625//24981863 chr15:67459118-67459119(+) m6A 5'UTR//CDS//exon       24284625//24981863 chr15:67459154-67459155(+) m6A 5'UTR//CDS//exon       24284625//24981863//26404942 chr15:67459173-67459174(+) m6A CDS//exon       24284625//24981863//26404942 chr15:67462900-67462901(+) m6A CDS//exon       24284625//24981863//26404942 chr15:67462971-67462972(+) m6A exon//intron       24284625//24981863 chr15:67466703-67466704(+) m6A exon//intron       24284625 chr15:67466805-67466806(+) m6A exon//intron       24284625 chr15:67473784-67473785(+) Cm CDS//intron       - chr15:67482753-67482754(+) m6A CDS//exon//intron       24284625//24209618//24981863 chr15:67482876-67482877(+) m6A 3'UTR//exon//intron       24284625//24209618//24981863//26404942//27773535//22608085 chr15:67482943-67482944(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr15:67483023-67483024(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr15:67483035-67483036(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr15:67483056-67483057(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr15:67483073-67483074(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67483144-67483145(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67483180-67483181(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67483229-67483230(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67483246-67483247(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67483310-67483311(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67483358-67483359(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67483405-67483406(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67483430-67483431(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67483480-67483481(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67483512-67483513(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67483525-67483526(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67483562-67483563(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67483916-67483917(+) m6A 3'UTR//intron       24284625//24981863 chr15:67483927-67483928(+) m6A 3'UTR//intron       24284625//24981863 chr15:67484050-67484051(+) m6A 3'UTR//intron       26404942 chr15:67484252-67484253(+) m6A 3'UTR//intron       24209618//24981863//26404942 chr15:67484320-67484321(+) m6A 3'UTR//intron       24209618//24981863//26404942 chr15:67484329-67484330(+) m6A 3'UTR//intron       24981863//26404942 chr15:67484334-67484335(+) m6A 3'UTR//intron       24981863//26404942 chr15:67484616-67484617(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr15:67484642-67484643(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67484675-67484676(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67484712-67484713(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67484720-67484721(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67484730-67484731(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67484830-67484831(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//22575960//22608085 chr15:67484870-67484871(+) m6A 3'UTR//intron       24284625//24209618 chr15:67484878-67484879(+) m6A 3'UTR//intron       24284625//24209618 chr15:67485027-67485028(+) m6A 3'UTR//intron       24981863 chr15:67485134-67485135(+) m6A 3'UTR//intron       24981863//26404942 chr15:67485187-67485188(+) m6A 3'UTR//intron       24981863//26404942 chr15:67485202-67485203(+) m6A 3'UTR//intron       24981863//26404942 chr15:67485289-67485290(+) m6A 3'UTR//exon       26404942 chr15:67485323-67485324(+) m6A 3'UTR//exon       26404942 chr15:67485510-67485511(+) m6A 3'UTR//exon       26404942 chr15:67485525-67485526(+) m6A 3'UTR       26404942 chr15:67485548-67485549(+) m6A 3'UTR       26404942 chr15:67485684-67485685(+) m6A 3'UTR       24981863 chr15:67485711-67485712(+) m6A 3'UTR       24981863 chr15:67485871-67485872(+) m6A 3'UTR       24284625 chr15:67485909-67485910(+) m6A 3'UTR       24284625 chr15:67485924-67485925(+) m6A 3'UTR       24284625 chr15:67485951-67485952(+) m6A 3'UTR       24284625 chr15:67486071-67486072(+) m6A 3'UTR       26404942 chr15:67486164-67486165(+) m6A 3'UTR       26404942 chr15:67486385-67486386(+) m6A 3'UTR       24284625//25456834//24981863//26404942//22575960//22608085 chr15:67486439-67486440(+) m6A 3'UTR       24284625//25456834//24981863//26404942//22575960//22608085 chr15:67486513-67486514(+) m6A 3'UTR       24284625//24981863//26404942 chr15:67486518-67486519(+) m6A 3'UTR       24284625//24981863//26404942 chr15:67486677-67486678(+) m6A 3'UTR       24209618//24981863//26404942//22608085 chr15:67486744-67486745(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22608085 chr15:67486762-67486763(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22608085 chr15:67486784-67486785(+) m6A 3'UTR       24209618//24981863//26404942//22608085 chr15:67486799-67486800(+) m6A 3'UTR       24209618//24981863//26404942//22608085 chr15:67486908-67486909(+) m6A 3'UTR       24284625//24981863//26404942 chr15:67486917-67486918(+) m6A 3'UTR       24284625//24981863//26404942 chr15:67486972-67486973(+) m6A 3'UTR       24284625//25456834//24981863//26404942//22608085 chr15:67487053-67487054(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22608085 chr15:67487060-67487061(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22608085 chr15:67487074-67487075(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22608085 chr15:67487094-67487095(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67487142-67487143(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:67487253-67487254(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr15:67487285-67487286(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	SMAD3	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: SMAD3

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.