Basic Information:

  VIRBase ID:  

VHID00504102

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          LRP4:  NM_002334     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	LRP4
miRBase Accession/Entrez ID	MIMAT0001581	4038
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	CLSS//CMS17//LRP-4//LRP10//MEGF7//SOST2

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	LRP4	chr11:46879556(-) A-I      3'UTR chr11:46937290(-) A-I      intronic chr11:46937289(-) A-I      intronic chr11:46937288(-) A-I      intronic chr11:46929604(-) A-I      intronic chr11:46933466(-) A-I      intronic chr11:46892262(-) A-I      intronic chr11:46937957(-) A-I      intronic chr11:46891737(-) A-I      intronic chr11:46906690(-) A-I      intronic chr11:46929551(-) A-I      intronic chr11:46933461(-) A-I      intronic chr11:46891744(-) A-I      intronic chr11:46929558(-) A-I      intronic chr11:46891818(-) A-I      intronic chr11:46929770(-) A-I      intronic chr11:46891819(-) A-I      intronic chr11:46892099(-) A-I      intronic chr11:46892113(-) A-I      intronic chr11:46892227(-) A-I      intronic chr11:46932321(-) A-I      intronic chr11:46892203(-) A-I      intronic chr11:46933490(-) A-I      intronic chr11:46937793(-) A-I      intronic chr11:46906747(-) A-I      intronic chr11:46883201(-) A-I      intronic chr11:46883205(-) A-I      intronic chr11:46887965(-) A-I      intronic chr11:46888109(-) A-I      intronic chr11:46888304(-) A-I      intronic chr11:46933121(-) A-I      intronic chr11:46888346(-) A-I      intronic chr11:46891692(-) A-I      intronic chr11:46929559(-) A-I      intronic chr11:46891734(-) A-I      intronic chr11:46938428(-) A-I      intronic chr11:46937243(-) A-I      intronic chr11:46905910(-) A-I      intronic chr11:46932297(-) A-I      intronic chr11:46906691(-) A-I      intronic chr11:46907090(-) A-I      intronic chr11:46905898(-) A-I      intronic chr11:46937298(-) A-I      intronic chr11:46933088(-) A-I      intronic chr11:46932307(-) A-I      intronic chr11:46937931(-) A-I      intronic chr11:46906651(-) A-I      intronic chr11:46906675(-) A-I      intronic chr11:46937340(-) A-I      intronic chr11:46933546(-) A-I      intronic chr11:46906362(-) A-I      intronic chr11:46906823(-) A-I      intronic chr11:46923465(-) A-I      intronic chr11:46929753(-) A-I      intronic chr11:46937939(-) A-I      intronic chr11:46932298(-) A-I      intronic chr11:46937859(-) A-I      intronic chr11:46937846(-) A-I      intronic chr11:46926470(-) A-I      intronic chr11:46924876(-) A-I      intronic chr11:46937162(-) A-I      intronic chr11:46929754(-) A-I      intronic chr11:46937879(-) A-I      intronic chr11:46906378(-) A-I      intronic chr11:46906770(-) A-I      intronic chr11:46906579(-) A-I      intronic chr11:46924872(-) A-I      intronic chr11:46909562(-) A-I      intronic chr11:46923456(-) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	LRP4	chr11:46878457-46878458(-) m6A 3'UTR//exon       24981863//27773535 chr11:46878498-46878499(-) m6A 3'UTR//exon       24981863//27773535 chr11:46878564-46878565(-) m6A 3'UTR//exon       24981863//27773535 chr11:46878632-46878633(-) m6A 3'UTR//exon       27773535 chr11:46878851-46878852(-) m6A 3'UTR//exon       - chr11:46878883-46878884(-) m6A 3'UTR//exon       - chr11:46878991-46878992(-) m6A 3'UTR//exon       24981863 chr11:46879029-46879030(-) m6A 3'UTR//exon       24981863 chr11:46879035-46879036(-) m6A 3'UTR//exon       24981863 chr11:46880010-46880011(-) m6A 3'UTR//exon       24284625//25456834//24981863//27773535//22608085 chr11:46880078-46880079(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22608085 chr11:46880098-46880099(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22608085 chr11:46880119-46880120(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22608085 chr11:46880166-46880167(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22608085 chr11:46880267-46880268(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:46880303-46880304(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr11:46880321-46880322(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr11:46880569-46880570(-) m6A CDS//exon       24284625//25456834//24981863//27773535 chr11:46880582-46880583(-) m6A CDS//exon       24284625//25456834//24981863//27773535 chr11:46880718-46880719(-) m6A CDS//exon       24284625//25456834//24981863//27773535 chr11:46890175-46890176(-) m6A CDS       27773535 chr11:46895040-46895041(-) m6A CDS//exon       - chr11:46895051-46895052(-) m6A CDS//exon       - chr11:46895066-46895067(-) m6A CDS//exon       - chr11:46895088-46895089(-) m6A CDS//exon       - chr11:46895112-46895113(-) m6A CDS//exon       - chr11:46895135-46895136(-) m6A CDS//exon       - chr11:46895212-46895213(-) m6A exon//intron       - chr11:46898179-46898180(-) m6A CDS       - chr11:46898308-46898309(-) m6A CDS       - chr11:46898760-46898761(-) m6A CDS       - chr11:46898781-46898782(-) m6A CDS       - chr11:46900790-46900791(-) Cm CDS       - chr11:46911529-46911530(-) m6A CDS       27773535 chr11:46911546-46911547(-) m6A CDS       27773535 chr11:46911568-46911569(-) m6A CDS       27773535 chr11:46911620-46911621(-) m6A CDS       27773535 chr11:46911634-46911635(-) m6A CDS       27773535 chr11:46916750-46916751(-) m6A CDS       - chr11:46916761-46916762(-) m6A CDS       - chr11:46939957-46939958(-) m6A 5'UTR       27773536 chr11:46940004-46940005(-) m6A 5'UTR       27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	LRP4	Cytosol HCC cell line (HepG2)     - Exosome Blood     - Membrane HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: LRP4

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.