Detail Information

Basic Information:


  VIRBase ID:  

VHID00504101

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           LRP3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p LRP3
miRBase
Accession/Entrez ID		 MIMAT0001581 4037
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - -

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR LRP3
chr19:33688304(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED LRP3
chr19:33695070(+) A-I intron -    19478186

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase LRP3
chr19:33668576-33668577(+) m6A 5'UTR       -
chr19:33668582-33668583(+) m6A 5'UTR       -
chr19:33668603-33668604(+) m6A 5'UTR       24209618
chr19:33668625-33668626(+) m6A 5'UTR       24209618
chr19:33685636-33685637(+) m6A 5'UTR//intron       24209618//25456834//24981863//27773536
chr19:33687638-33687639(+) m6A 5'UTR//CDS       -
chr19:33687657-33687658(+) m6A 5'UTR//CDS//exon       24284625
chr19:33694788-33694789(+) m6A exon//intron       24284625
chr19:33695355-33695356(+) m6A exon//intron       25456834
chr19:33695366-33695367(+) m6A exon//intron       25456834
chr19:33695389-33695390(+) m6A exon//intron       25456834
chr19:33695404-33695405(+) m6A exon//intron       25456834
chr19:33695432-33695433(+) m6A exon//intron       25456834
chr19:33695587-33695588(+) m6A CDS//exon       -
chr19:33695784-33695785(+) m6A exon//intron       24284625
chr19:33696321-33696322(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085
chr19:33696391-33696392(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085
chr19:33696481-33696482(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085
chr19:33696511-33696512(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085
chr19:33696535-33696536(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085
chr19:33696544-33696545(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085
chr19:33696572-33696573(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085
chr19:33696631-33696632(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr19:33696966-33696967(+) Y CDS//exon       26075521
chr19:33697027-33697028(+) m6A CDS//exon       24284625//24981863
chr19:33697111-33697112(+) m6A CDS//exon       24284625
chr19:33697993-33697994(+) m6A CDS//exon       24284625//25456834
chr19:33698064-33698065(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085
chr19:33698134-33698135(+) m6A CDS//exon       24284625//25456834//24981863//22575960//22608085
chr19:33698161-33698162(+) m6A CDS//exon       24284625//25456834//24981863//22575960//22608085
chr19:33698201-33698202(+) m6A CDS//exon       24284625//25456834//24981863//26404942//22575960//22608085
chr19:33698236-33698237(+) m6A CDS//exon       24284625//25456834//24981863//26404942//22575960//22608085
chr19:33698257-33698258(+) m6A CDS//exon       24284625//25456834//24981863//22575960//22608085
chr19:33698263-33698264(+) m6A CDS//exon       24284625//25456834//24981863//22575960//22608085
chr19:33698341-33698342(+) m6A CDS//exon       24284625//25456834//24981863//22575960//22608085
chr19:33698416-33698417(+) m6A CDS//exon       24284625//25456834

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate LRP3
Exosome Blood     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: LRP3

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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