Basic Information:

  VIRBase ID:  

VHID00504090

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          LOX:  NM_002317     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	LOX
miRBase Accession/Entrez ID	MIMAT0001581	4015
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	AAT10

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	LOX	chr5:121399323-121399324(-) m6A 3'UTR       27773535 chr5:121399903-121399904(-) m6A 3'UTR       27773535 chr5:121399917-121399918(-) m6A 3'UTR       27773535 chr5:121399970-121399971(-) m6A 3'UTR       27773535 chr5:121400002-121400003(-) m6A 3'UTR       27773535 chr5:121400012-121400013(-) m6A 3'UTR       27773535 chr5:121400022-121400023(-) m6A 3'UTR       27773535 chr5:121400071-121400072(-) m6A 3'UTR       27773535 chr5:121400099-121400100(-) m6A 3'UTR       27773535 chr5:121401960-121401961(-) m6A 3'UTR//exon       27773535 chr5:121401990-121401991(-) m6A 3'UTR//exon       27773535 chr5:121402039-121402040(-) m6A 3'UTR//exon       27773535 chr5:121402050-121402051(-) m6A 3'UTR//exon       27773535 chr5:121402069-121402070(-) m6A 3'UTR//exon       27773535 chr5:121402075-121402076(-) m6A 3'UTR//exon       27773535 chr5:121402305-121402306(-) m6A 3'UTR//exon       24981863//27773535//22608085 chr5:121402328-121402329(-) m6A 3'UTR//exon       24981863//27773535//22608085 chr5:121402335-121402336(-) m6A 3'UTR//exon       24981863//27773535//22608085 chr5:121402373-121402374(-) m6A 3'UTR//exon       24981863//27773535//22608085 chr5:121402423-121402424(-) m6A 3'UTR//exon       24981863//22608085 chr5:121411156-121411157(-) m6A 3'UTR//CDS//exon       27773535 chr5:121411164-121411165(-) m6A 3'UTR//CDS//exon       27773535 chr5:121412599-121412600(-) m6A CDS//exon//intron       27773535 chr5:121412771-121412772(-) m6A exon//intron       22608085 chr5:121412894-121412895(-) m6A exon//intron       25456834//24981863//22608085 chr5:121413098-121413099(-) m6A CDS       24284625//24981863//22608085 chr5:121413244-121413245(-) m6A CDS       24284625//24981863//22575960 chr5:121413249-121413250(-) m6A CDS       24284625//24981863//22575960 chr5:121413468-121413469(-) m6A CDS       27773536 chr5:121413531-121413532(-) m6A CDS       27773536 chr5:121413808-121413809(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27773535//27773536//22608085 chr5:121413901-121413902(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27773535//27773536//22575960//22608085 chr5:121413932-121413933(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27773535//27773536//22608085 chr5:121413951-121413952(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27773536//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	LOX	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Endoplasmic reticulum Human fibrosarcoma cells (HT1080)     25753659 Exosome Blood     - Nucleus K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: LOX

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.