Basic Information:

  VIRBase ID:  

VHID00504041

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          LDHA:  NR_028500     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	LDHA
miRBase Accession/Entrez ID	MIMAT0001581	3939
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	GSD11//HEL-S-133P//LDHM//PIG19

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	LDHA	chr11:18419235(+) A-I      intronic chr11:18426267(+) A-I      intronic chr11:18427630(+) A-I      intronic chr11:18427710(+) A-I      intronic chr11:18427735(+) A-I      intronic chr11:18428068(+) A-I      intronic chr11:18428077(+) A-I      intronic chr11:18428103(+) A-I      intronic chr11:18428152(+) A-I      intronic chr11:18428188(+) A-I      intronic chr11:18425890(+) A-I      intronic chr11:18428352(+) A-I      intronic chr11:18425850(+) A-I      intronic chr11:18420336(+) A-I      intronic chr11:18427587(+) A-I      intronic chr11:18419186(+) A-I      intronic chr11:18428062(+) A-I      intronic chr11:18427696(+) A-I      intronic chr11:18425791(+) A-I      intronic chr11:18425643(+) A-I      intronic chr11:18426192(+) A-I      intronic chr11:18428120(+) A-I      intronic chr11:18428414(+) A-I      intronic chr11:18428088(+) A-I      intronic chr11:18426193(+) A-I      intronic chr11:18426189(+) A-I      intronic chr11:18426178(+) A-I      intronic chr11:18425897(+) A-I      intronic chr11:18425796(+) A-I      intronic chr11:18428418(+) A-I      intronic chr11:18425577(+) A-I      intronic chr11:18425541(+) A-I      intronic chr11:18426195(+) A-I      intronic chr11:18420363(+) A-I      intronic chr11:18419104(+) A-I      intronic chr11:18425497(+) A-I      intronic chr11:18419192(+) A-I      intronic chr11:18426208(+) A-I      intronic chr11:18419966(+) A-I      intronic chr11:18420326(+) A-I      intronic chr11:18420287(+) A-I      intronic chr11:18420278(+) A-I      intronic chr11:18428419(+) A-I      intronic chr11:18419315(+) A-I      intronic chr11:18428102(+) A-I      intronic chr11:18419278(+) A-I      intronic chr11:18427612(+) A-I      intronic chr11:18419179(+) A-I      intronic chr11:18419142(+) A-I      intronic chr11:18420327(+) A-I      intronic chr11:18425659(+) A-I      intronic chr11:18425617(+) A-I      intronic chr11:18425595(+) A-I      intronic chr11:18428078(+) A-I      intronic chr11:18428143(+) A-I      intronic chr11:18425542(+) A-I      intronic chr11:18420346(+) A-I      intronic chr11:18419117(+) A-I      intronic chr11:18420262(+) A-I      intronic chr11:18420422(+) A-I      intronic chr11:18425794(+) A-I      intronic chr11:18419087(+) A-I      intronic chr11:18425501(+) A-I      intronic chr11:18427613(+) A-I      intronic chr11:18420423(+) A-I      intronic chr11:18428456(+) A-I      intronic chr11:18427933(+) A-I      intronic chr11:18428080(+) A-I      intronic chr11:18419283(+) A-I      intronic chr11:18419181(+) A-I      intronic chr11:18427606(+) A-I      intronic chr11:18428108(+) A-I      intronic chr11:18427687(+) A-I      intronic chr11:18419201(+) A-I      intronic chr11:18427693(+) A-I      intronic chr11:18420368(+) A-I      intronic chr11:18425797(+) A-I      intronic chr11:18425662(+) A-I      intronic chr11:18420530(+) A-I      intronic chr11:18419312(+) A-I      intronic chr11:18421206(+) A-I      intronic chr11:18427642(+) A-I      intronic chr11:18421177(+) A-I      intronic chr11:18421150(+) A-I      intronic chr11:18425813(+) A-I      intronic chr11:18427553(+) A-I      intronic chr11:18428410(+) A-I      intronic chr11:18427895(+) A-I      intronic chr11:18428468(+) A-I      intronic chr11:18425644(+) A-I      intronic chr11:18427997(+) A-I      intronic chr11:18425619(+) A-I      intronic chr11:18425800(+) A-I      intronic chr11:18419120(+) A-I      intronic chr11:18427652(+) A-I      intronic chr11:18420518(+) A-I      intronic chr11:18428366(+) A-I      intronic chr11:18425582(+) A-I      intronic chr11:18427535(+) A-I      intronic chr11:18427715(+) A-I      intronic chr11:18428449(+) A-I      intronic chr11:18425902(+) A-I      intronic chr11:18425499(+) A-I      intronic chr11:18428945(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	LDHA	chr11:18428945(+) A-I intron -    21960545 chr11:18419117(+) A-G intron -    22484847 chr11:18419201(+) A-G intron -    22484847 chr11:18425791(+) A-G intron -    22484847 chr11:18426093(+) T-C intron -    22484847 chr11:18427652(+) A-G intron -    22484847 chr11:18428143(+) A-G intron -    22484847 chr11:18428366(+) A-G intron -    22484847 chr11:18428414(+) A-G intron -    22484847 chr11:18428418(+) A-G intron -    22484847 chr11:18428456(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	LDHA	chr11:18418320-18418321(+) m6A 5'UTR//intron       24981863 chr11:18418436-18418437(+) m6A CDS//exon       27773535 chr11:18418586-18418587(+) m6A exon//intron       22575960 chr11:18421070-18421071(+) m6A 3'UTR//CDS//exon//intron       27773535 chr11:18422077-18422078(+) Gm exon//intron       - chr11:18422482-18422483(+) m6A 3'UTR//CDS//exon//intron       27773535 chr11:18422527-18422528(+) m6A 3'UTR//CDS//exon//intron       27773535 chr11:18424434-18424435(+) m6A 3'UTR//CDS//exon//intron       22575960 chr11:18424543-18424544(+) m6A 3'UTR//CDS//exon//intron       27773535//22575960 chr11:18425284-18425285(+) m6A 3'UTR//CDS//exon       27773535//22575960 chr11:18425305-18425306(+) m6A 3'UTR//CDS//exon       27773535//22575960 chr11:18425322-18425323(+) m6A 3'UTR//CDS//exon       27773535//22575960 chr11:18427013-18427014(+) m6A 3'UTR//CDS//exon//intron       27773535//22575960 chr11:18427043-18427044(+) m6A 3'UTR//CDS//exon//intron       27773535//22575960 chr11:18428716-18428717(+) m6A 3'UTR//CDS//exon//intron       27773535 chr11:18428733-18428734(+) m6A 3'UTR//CDS//exon//intron       27773535 chr11:18428944-18428945(+) m6A 3'UTR//exon       27773535 chr11:18428954-18428955(+) m6A 3'UTR//exon       27773535 chr11:18429172-18429173(+) m6A 3'UTR//exon       27773535//22575960 chr11:18429280-18429281(+) m6A 3'UTR//exon       27773535 chr11:18429331-18429332(+) m6A 3'UTR       27773535 chr11:18429369-18429370(+) m6A 3'UTR       27773535 chr11:18429380-18429381(+) m6A 3'UTR       27773535 chr11:18429387-18429388(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	LDHA	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: LDHA

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.