Detail Information

Basic Information:


  VIRBase ID:  

VHID00503978

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           KRAS:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p KRAS
miRBase
Accession/Entrez ID		 MIMAT0001581 3845
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - 'C-K-RAS//C-K-RAS//c-Ki-ras//c-Ki-ras2//CFC2//K-Ras//K-Ras 2//K-RAS2A//K-RAS2B//K-RAS4A//K-RAS4B//KI-RAS//KRAS1//KRAS2//NS//NS3//OES//RALD//RASK2

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR KRAS
chr12:25364397(-) A-I      intronic
chr12:25384258(-) A-I      intronic
chr12:25384200(-) A-I      intronic
chr12:25372046(-) A-I      intronic
chr12:25384290(-) A-I      intronic
chr12:25374360(-) A-I      intronic
chr12:25384190(-) A-I      intronic
chr12:25374361(-) A-I      intronic
chr12:25384240(-) A-I      intronic
chr12:25374327(-) A-I      intronic
chr12:25372011(-) A-I      intronic
chr12:25374275(-) A-I      intronic
chr12:25384234(-) A-I      intronic
chr12:25372052(-) A-I      intronic
chr12:25372051(-) A-I      intronic
chr12:25372048(-) A-I      intronic
chr12:25372037(-) A-I      intronic
chr12:25372042(-) A-I      intronic
chr12:25372043(-) A-I      intronic
chr12:25383424(-) A-I      intronic
chr12:25383462(-) A-I      intronic
chr12:25374331(-) A-I      intronic
chr12:25383413(-) A-I      intronic
chr12:25383360(-) A-I      intronic
chr12:25382978(-) A-I      intronic
chr12:25382867(-) A-I      intronic
chr12:25382827(-) A-I      intronic
chr12:25381858(-) A-I      intronic
chr12:25374975(-) A-I      intronic
chr12:25384132(-) A-I      intronic
chr12:25401045(-) A-I      intronic
chr12:25401203(-) A-I      intronic
chr12:25365438(-) A-I      intronic
chr12:25374971(-) A-I      intronic
chr12:25383515(-) A-I      intronic
chr12:25370746(-) A-I      intronic
chr12:25381830(-) A-I      intronic
chr12:25372001(-) A-I      intronic
chr12:25374258(-) A-I      intronic
chr12:25383499(-) A-I      intronic
chr12:25374264(-) A-I      intronic
chr12:25381750(-) A-I      intronic
chr12:25382964(-) A-I      intronic
chr12:25382915(-) A-I      intronic
chr12:25374961(-) A-I      intronic
chr12:25370728(-) A-I      intronic
chr12:25383418(-) A-I      intronic
chr12:25382779(-) A-I      intronic
chr12:25383510(-) A-I      intronic
chr12:25402183(-) A-I      intronic
chr12:25369459(-) A-I      intronic
chr12:25399380(-) A-I      intronic
chr12:25374252(-) A-I      intronic
chr12:25370742(-) A-I      intronic
chr12:25365781(-) A-I      intronic
chr12:25381735(-) A-I      intronic
chr12:25371969(-) A-I      intronic
chr12:25370776(-) A-I      intronic
chr12:25374400(-) A-I      intronic
chr12:25374342(-) A-I      intronic
chr12:25383306(-) A-I      intronic
chr12:25374234(-) A-I      intronic
chr12:25383493(-) A-I      intronic
chr12:25383365(-) A-I      intronic
chr12:25369311(-) A-I      intronic
chr12:25374263(-) A-I      intronic
chr12:25384160(-) A-I      intronic
chr12:25365830(-) A-I      intronic
chr12:25369468(-) A-I      intronic
chr12:25365829(-) A-I      intronic
chr12:25374304(-) A-I      intronic
chr12:25364479(-) A-I      intronic
chr12:25374395(-) A-I      intronic
chr12:25365845(-) A-I      intronic
chr12:25365441(-) A-I      intronic
chr12:25365803(-) A-I      intronic
chr12:25365735(-) A-I      intronic
chr12:25382886(-) A-I      intronic
chr12:25384213(-) A-I      intronic
chr12:25382928(-) A-I      intronic
chr12:25384174(-) A-I      intronic
chr12:25374256(-) A-I      intronic
chr12:25374423(-) A-I      intronic
chr12:25383480(-) A-I      intronic
chr12:25384289(-) A-I      intronic
chr12:25365741(-) A-I      intronic
chr12:25381825(-) A-I      intronic
chr12:25373896(-) A-I      intronic
chr12:25374290(-) A-I      intronic
chr12:25365415(-) A-I      intronic
chr12:25365746(-) A-I      intronic
chr12:25370828(-) A-I      intronic
chr12:25382935(-) A-I      intronic
chr12:25383479(-) A-I      intronic
chr12:25374935(-) A-I      intronic
chr12:25374371(-) A-I      intronic
chr12:25369347(-) A-I      intronic
chr12:25384184(-) A-I      intronic
chr12:25374340(-) A-I      intronic
chr12:25374895(-) A-I      intronic
chr12:25401160(-) A-I      intronic
chr12:25384248(-) A-I      intronic
chr12:25381776(-) A-I      intronic
chr12:25374372(-) A-I      intronic
chr12:25364422(-) A-I      intronic
chr12:25401321(-) A-I      intronic
chr12:25383557(-) A-I      intronic
chr12:25383559(-) A-I      intronic
chr12:25374295(-) A-I      intronic
chr12:25372145(-) A-I      intronic
chr12:25401161(-) A-I      intronic
chr12:25382940(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED KRAS
chr12:25365741(-) A-I intron -    21960545   //22327324
chr12:25365781(-) A-I intron -    21960545   //22327324
chr12:25365415(-) A-I intron -    21960545
chr12:25365416(-) A-I intron -    21960545
chr12:25365829(-) A-I intron -    21960545
chr12:25365830(-) A-I intron -    21960545
chr12:25365833(-) A-I intron -    21960545
chr12:25369307(-) A-I intron -    21960545
chr12:25369341(-) A-I intron -    21960545
chr12:25369347(-) A-I intron -    21960545
chr12:25370623(-) A-I intron -    21960545
chr12:25370728(-) A-I intron -    21960545
chr12:25370746(-) A-I intron -    21960545
chr12:25370776(-) A-I intron -    21960545
chr12:25370828(-) A-I intron -    21960545
chr12:25382901(-) A-I intron -    21960545
chr12:25383306(-) A-I intron -    21960545
chr12:25383424(-) A-I intron -    21960545
chr12:25383557(-) A-I intron -    21960545
chr12:25360448(-) G-T exon 3'UTR    22484847
chr12:25360449(-) G-T exon 3'UTR    22484847
chr12:25365741(-) A-G intron -    22484847
chr12:25365781(-) A-G intron -    22484847
chr12:25365958(-) T-C intron -    22484847
chr12:25374244(-) T-C intron -    22484847
chr12:25382928(-) A-G intron -    22484847
chr12:25382935(-) A-G intron -    22484847
chr12:25383480(-) A-G intron -    22484847
chr12:25369303(-) T-C intron -    22484847
chr12:25370828(-) A-G intron -    22484847
chr12:25372145(-) A-G intron -    22484847
chr12:25374395(-) A-G intron -    22484847
chr12:25374400(-) A-G intron -    22484847
chr12:25374423(-) A-G intron -    22484847
chr12:25374895(-) A-G intron -    22484847
chr12:25382780(-) T-C intron -    22484847
chr12:25383365(-) A-G intron -    22484847
chr12:25383479(-) A-G intron -    22484847
chr12:25383493(-) A-G intron -    22484847
chr12:25383510(-) A-G intron -    22484847
chr12:25384160(-) A-G intron -    22484847
chr12:25384184(-) A-G intron -    22484847
chr12:25401160(-) A-G intron -    22484847
chr12:25401161(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase KRAS
chr12:25362748-25362749(-) m6A 3'UTR//CDS       24981863//27773535
chr12:25362800-25362801(-) m6A 3'UTR//CDS       24981863//27773535//27371828
chr12:25368415-25368416(-) m6A CDS//intron       27773535//27371828
chr12:25378550-25378551(-) m6A CDS//intron       24981863//27773535//27371828//22608085
chr12:25378555-25378556(-) m6A CDS//intron       24981863//27773535//27371828//22608085
chr12:25378567-25378568(-) m6A CDS//intron       24981863//27773535//27371828//22608085
chr12:25378602-25378603(-) m6A CDS//intron       24981863//27773535//27371828//22608085
chr12:25378613-25378614(-) m6A CDS//intron       24981863//27773535//27371828//22608085
chr12:25378620-25378621(-) m6A CDS//intron       24981863//27773535//27371828//22608085
chr12:25378627-25378628(-) m6A CDS//intron       24981863//27773535//27371828//22608085
chr12:25378683-25378684(-) m6A CDS//intron       24981863//27773535//27371828//22608085
chr12:25378703-25378704(-) m6A CDS//intron       24981863//27773535//27371828//22608085
chr12:25380237-25380238(-) m6A CDS//intron       24981863//26404942//27773535
chr12:25380251-25380252(-) m6A CDS//intron       24981863//26404942//27773535
chr12:25380309-25380310(-) m6A CDS//intron       24981863//26404942//27773535
chr12:25387487-25387488(-) m6A 3'UTR//intron       27773535
chr12:25387524-25387525(-) m6A 3'UTR//intron       27773535
chr12:25398303-25398304(-) m6A CDS       24209618//27371828
chr12:25403761-25403762(-) m6A 5'UTR       24209618//24981863//27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate KRAS
Chromatin K562 cells     -
Exosome Serum     -
Mitochondrion HDF cells     16178658
Nucleoplasm K562 cells     -
Nucleus K562 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: KRAS

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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