Basic Information:

  VIRBase ID:  

VHID00503851

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          ITGB1:  NM_033668     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	ITGB1
miRBase Accession/Entrez ID	MIMAT0001581	3688
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	CD29//FNRB//GPIIA//MDF2//MSK12//VLA-BETA//VLAB

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ITGB1	chr10:33229190(-) A-I      intronic chr10:33229151(-) A-I      intronic chr10:33229092(-) A-I      intronic chr10:33235845(-) A-I      intronic chr10:33235841(-) A-I      intronic chr10:33235840(-) A-I      intronic chr10:33229191(-) A-I      intronic chr10:33236049(-) A-I      intronic chr10:33235975(-) A-I      intronic chr10:33235974(-) A-I      intronic chr10:33235970(-) A-I      intronic chr10:33235936(-) A-I      intronic chr10:33235932(-) A-I      intronic chr10:33229106(-) A-I      intronic chr10:33229104(-) A-I      intronic chr10:33229141(-) A-I      intronic chr10:33234415(-) A-I      intronic chr10:33234501(-) A-I      intronic chr10:33235942(-) A-I      intronic chr10:33231655(-) A-I      intronic chr10:33231564(-) A-I      intronic chr10:33195338(-) A-I      intronic chr10:33229211(-) A-I      intronic chr10:33231757(-) A-I      intronic chr10:33236044(-) A-I      intronic chr10:33231648(-) A-I      intronic chr10:33234362(-) A-I      intronic chr10:33195333(-) A-I      intronic chr10:33236043(-) A-I      intronic chr10:33192117(-) A-I      intronic chr10:33234337(-) A-I      intronic chr10:33231613(-) A-I      intronic chr10:33234342(-) A-I      intronic chr10:33195314(-) A-I      intronic chr10:33235909(-) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ITGB1	chr10:33189714-33189715(-) m6A 3'UTR       27773535 chr10:33189798-33189799(-) m6A 3'UTR       27773535 chr10:33190128-33190129(-) m6A 3'UTR       24981863 chr10:33190235-33190236(-) m6A 3'UTR       24284625//24981863 chr10:33190296-33190297(-) m6A 3'UTR       24284625 chr10:33190303-33190304(-) m6A 3'UTR       24284625 chr10:33190314-33190315(-) m6A 3'UTR       24284625 chr10:33200494-33200495(-) m6A CDS       22575960 chr10:33200919-33200920(-) m6A CDS       26404942//22575960 chr10:33200962-33200963(-) m6A CDS       24981863//26404942//22575960 chr10:33200989-33200990(-) m6A CDS       24981863//26404942//22575960 chr10:33201027-33201028(-) m6A CDS       24981863//26404942//22575960 chr10:33208834-33208835(-) m6A CDS       24981863//26404942//22575960 chr10:33209219-33209220(-) m6A CDS       26404942//22575960 chr10:33211237-33211238(-) m6A CDS       26404942//22575960 chr10:33211263-33211264(-) m6A CDS       26404942//22575960 chr10:33211608-33211609(-) m6A CDS       26404942//22575960 chr10:33211630-33211631(-) m6A CDS       26404942 chr10:33212557-33212558(-) m6A CDS       26404942 chr10:33212587-33212588(-) m6A CDS       26404942 chr10:33214870-33214871(-) m6A CDS       26404942//22575960 chr10:33214882-33214883(-) m6A CDS       26404942//22575960 chr10:33214949-33214950(-) m6A CDS//exon       24981863//26404942//22575960 chr10:33214954-33214955(-) m6A CDS//exon       24981863//26404942//22575960 chr10:33214970-33214971(-) m6A CDS//exon       24981863//26404942//22575960 chr10:33215013-33215014(-) m6A CDS//exon       24981863//26404942//22575960 chr10:33217032-33217033(-) m6A CDS//intron       24981863//22575960 chr10:33217069-33217070(-) m6A CDS//intron       22575960 chr10:33217119-33217120(-) m6A CDS//intron       26404942//22575960 chr10:33217149-33217150(-) m6A CDS//intron       24981863//26404942 chr10:33217180-33217181(-) m6A CDS//intron       24981863//26404942 chr10:33218756-33218757(-) Am CDS//intron       - chr10:33218821-33218822(-) m6A CDS//exon       24981863//26404942//27773535 chr10:33224422-33224423(-) m6A 5'UTR//CDS//exon       24981863 chr10:33224456-33224457(-) m6A 5'UTR//CDS//exon       24981863 chr10:33224828-33224829(-) m6A 5'UTR//intron       24981863 chr10:33244574-33244575(-) m6A 5'UTR//intron       27773536 chr10:33246742-33246743(-) m6A 5'UTR//intron       24209618//24981863//27773536 chr10:33247121-33247122(-) m6A 5'UTR//exon//intron       24209618//25456834//24981863//27773536 chr10:33247496-33247497(-) m6A exon//intron       25456834//24981863//27773536 chr10:33247577-33247578(-) m6A exon//intron       24981863 chr10:33247586-33247587(-) m6A exon//intron       24981863 chr10:33247754-33247755(-) m6A exon//intron       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ITGB1	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Endoplasmic reticulum U2OS cells     22679391 Exosome Blood     - Membrane K562 cells     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)|HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: ITGB1

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.