Basic Information:

  VIRBase ID:  

VHID00503842

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          ITGA4:  NM_001316312     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	ITGA4
miRBase Accession/Entrez ID	MIMAT0001581	3676
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	CD49D//IA4

RNA Editing:

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ITGA4	chr2:182355984(+) G-A intron -    22484847 chr2:182355985(+) C-A intron -    22484847 chr2:182395764(+) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ITGA4	chr2:182322086-182322087(+) m6A 5'UTR//exon       24981863 chr2:182322153-182322154(+) m6A 5'UTR//exon       24981863//27371828 chr2:182322270-182322271(+) m6A 5'UTR//exon       - chr2:182322404-182322405(+) m6A CDS//exon       - chr2:182322490-182322491(+) m6A CDS//exon       - chr2:182400175-182400176(+) m6A CDS       24981863//26404942//22608085 chr2:182400204-182400205(+) m6A CDS       24981863//26404942//22608085 chr2:182400213-182400214(+) m6A CDS       24981863//26404942//22608085 chr2:182400256-182400257(+) m6A 3'UTR       24981863//26404942//22608085 chr2:182400283-182400284(+) m6A 3'UTR       24981863//26404942//22608085 chr2:182400316-182400317(+) m6A 3'UTR       24981863//26404942//22608085 chr2:182400350-182400351(+) m6A 3'UTR       24209618//24981863//26404942//22608085 chr2:182400435-182400436(+) m6A 3'UTR       24981863//26404942//22608085 chr2:182400493-182400494(+) m6A 3'UTR       24981863//26404942//22608085 chr2:182400825-182400826(+) m6A 3'UTR       26404942 chr2:182400854-182400855(+) m6A 3'UTR       26404942 chr2:182400862-182400863(+) m6A 3'UTR       26404942 chr2:182400869-182400870(+) m6A 3'UTR       26404942 chr2:182400874-182400875(+) m6A 3'UTR       26404942

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ITGA4	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: ITGA4

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.