Detail Information

Basic Information:


  VIRBase ID:  

VHID00503835

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           IRS1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p IRS1
miRBase
Accession/Entrez ID		 MIMAT0001581 3667
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - HIRS-1

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR IRS1
chr2:227630995(-) A-I      intronic
chr2:227650802(-) A-I      intronic
chr2:227631004(-) A-I      intronic
chr2:227630996(-) A-I      intronic
chr2:227631047(-) A-I      intronic
chr2:227650207(-) A-I      intronic
chr2:227631018(-) A-I      intronic
chr2:227630977(-) A-I      intronic
chr2:227631039(-) A-I      intronic
chr2:227649430(-) A-I      intronic
chr2:227649318(-) A-I      intronic
chr2:227649287(-) A-I      intronic
chr2:227631160(-) A-I      intronic
chr2:227631126(-) A-I      intronic
chr2:227631125(-) A-I      intronic
chr2:227631112(-) A-I      intronic
chr2:227631017(-) A-I      intronic
chr2:227630976(-) A-I      intronic
chr2:227630947(-) A-I      intronic
chr2:227629901(-) A-I      intronic
chr2:227649271(-) A-I      intronic
chr2:227650317(-) A-I      intronic
chr2:227650139(-) A-I      intronic
chr2:227650084(-) A-I      intronic
chr2:227650062(-) A-I      intronic
chr2:227650053(-) A-I      intronic
chr2:227649333(-) A-I      intronic
chr2:227650225(-) A-I      intronic
chr2:227650197(-) A-I      intronic
chr2:227649166(-) A-I      intronic
chr2:227649411(-) A-I      intronic
chr2:227649412(-) A-I      intronic
chr2:227649321(-) A-I      intronic
chr2:227649332(-) A-I      intronic
chr2:227649235(-) A-I      intronic
chr2:227631058(-) A-I      intronic
chr2:227630988(-) A-I      intronic
chr2:227611634(-) A-I      intronic
chr2:227649224(-) A-I      intronic
chr2:227650315(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase IRS1
chr2:227600394-227600395(-) m6A 3'UTR       27773535
chr2:227600560-227600561(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535
chr2:227600602-227600603(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085
chr2:227600702-227600703(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085
chr2:227600723-227600724(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085
chr2:227600795-227600796(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085
chr2:227600882-227600883(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085
chr2:227600912-227600913(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085
chr2:227600958-227600959(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535
chr2:227656939-227656940(-) m6A exon//intron       24284625//24981863//27773535
chr2:227656945-227656946(-) m6A exon//intron       24284625//24981863//27773535
chr2:227656961-227656962(-) m6A exon//intron       27773535
chr2:227657021-227657022(-) m6A exon//intron       24284625//24981863
chr2:227659715-227659716(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535
chr2:227659735-227659736(-) m6A CDS//exon       24284625//24209618//24981863//27773535
chr2:227659860-227659861(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr2:227659887-227659888(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr2:227659894-227659895(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr2:227659912-227659913(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr2:227659959-227659960(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr2:227660147-227660148(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr2:227660182-227660183(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr2:227660227-227660228(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr2:227660259-227660260(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr2:227660405-227660406(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27371828//22575960//22608085
chr2:227660446-227660447(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr2:227660562-227660563(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr2:227660620-227660621(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//27773536//22575960//22608085
chr2:227660648-227660649(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr2:227660903-227660904(-) m6A CDS       24284625//24209618//24981863//26404942//22575960
chr2:227660917-227660918(-) m6A CDS       24284625//24209618//24981863//26404942//22575960
chr2:227661190-227661191(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535
chr2:227661235-227661236(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr2:227661253-227661254(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr2:227661309-227661310(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr2:227661356-227661357(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr2:227661377-227661378(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr2:227661481-227661482(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr2:227661562-227661563(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr2:227661649-227661650(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr2:227661744-227661745(-) m6A CDS       24284625//25456834//24981863//26404942//27773535//22575960//22608085
chr2:227661839-227661840(-) m6A CDS       24284625//24981863//26404942//27773535//22575960//22608085
chr2:227661881-227661882(-) m6A CDS       24284625//24981863//26404942//27773535//22575960//22608085
chr2:227661962-227661963(-) m6A CDS       24284625//24981863//27773535//22575960
chr2:227662394-227662395(-) m6A CDS       24284625
chr2:227662700-227662701(-) m6A CDS       24284625//24209618//25456834//27773535//22575960
chr2:227662711-227662712(-) m6A CDS       24284625//24209618//25456834//27773535//22575960
chr2:227662798-227662799(-) m6A CDS       24284625//24209618//25456834//24981863
chr2:227662825-227662826(-) m6A CDS       24284625//24209618//25456834//24981863
chr2:227662861-227662862(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr2:227662883-227662884(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr2:227662921-227662922(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27371828//22575960//22608085
chr2:227662928-227662929(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27371828//22575960//22608085
chr2:227662983-227662984(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27371828//22575960//22608085
chr2:227663011-227663012(-) m6A CDS       24284625//24209618//25456834//24981863//27371828//22575960//22608085
chr2:227663143-227663144(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr2:227663161-227663162(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr2:227663215-227663216(-) m6A CDS       24284625//24209618//24981863//27773535//27371828
chr2:227663391-227663392(-) m6A CDS       24284625
chr2:227663664-227663665(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27371828//22575960//22608085
chr2:227663739-227663740(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085
chr2:227663805-227663806(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085
chr2:227663833-227663834(-) m6A 5'UTR       24284625//24209618//25456834//24981863//26404942//27371828//22575960//22608085
chr2:227663886-227663887(-) m6A 5'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr2:227663956-227663957(-) m6A 5'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr2:227663974-227663975(-) m6A 5'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr2:227664306-227664307(-) m6A 5'UTR       24284625//25456834//24981863//27371828//27773536
chr2:227664317-227664318(-) m6A 5'UTR       24284625//25456834//24981863//27371828//27773536
chr2:227664334-227664335(-) m6A 5'UTR       24284625//25456834//24981863//27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate IRS1
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleus K562 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: IRS1

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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