Basic Information:

  VIRBase ID:  

VHID00503831

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          IRF4:  NR_046000     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	IRF4
miRBase Accession/Entrez ID	MIMAT0001581	3662
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	LSIRF//MUM1//NF-EM5//SHEP8

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	IRF4	chr6:406463(+) A-I      intronic chr6:406474(+) A-I      intronic chr6:407708(+) A-I      3'UTR chr6:407778(+) A-I      3'UTR chr6:402790(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	IRF4	chr6:400716(+) A-I intron -    22327324 chr6:402754(+) A-T intron -    22484847 chr6:402790(+) A-G intron -    22484847 chr6:402820(+) C-T intron -    22484847 chr6:402873(+) G-A intron -    22484847 chr6:402931(+) A-C intron -    22484847 chr6:402947(+) G-A intron -    22484847 chr6:402982(+) T-C intron -    22484847 chr6:406309(+) T-C intron -    22484847 chr6:406463(+) A-G intron -    22484847 chr6:406541(+) C-A intron -    22484847 chr6:407630(+) T-C intron -    22484847 chr6:407649(+) G-T intron -    22484847 chr6:407708(+) A-G intron -    22484847 chr6:407778(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	IRF4	chr6:391773-391774(+) m6A 5'UTR//exon       27371828 chr6:393119-393120(+) m6A 5'UTR//intron       27371828 chr6:393156-393157(+) m6A CDS//intron       27371828 chr6:393333-393334(+) m6A CDS//exon//intron       26404942 chr6:394869-394870(+) m6A CDS//exon       26404942 chr6:394908-394909(+) m6A CDS//exon       26404942 chr6:394930-394931(+) m6A CDS//exon       26404942 chr6:394953-394954(+) m6A CDS//exon       26404942 chr6:394962-394963(+) m6A CDS//exon       26404942 chr6:395870-395871(+) m6A CDS//exon       - chr6:396003-396004(+) m6A exon//intron       - chr6:396018-396019(+) m6A exon//intron       - chr6:396026-396027(+) m6A exon//intron       - chr6:396065-396066(+) m6A exon//intron       - chr6:397153-397154(+) m6A CDS//exon       - chr6:397211-397212(+) m6A CDS//exon       - chr6:397485-397486(+) m6A exon//intron       - chr6:397516-397517(+) m6A exon//intron       - chr6:398844-398845(+) m6A CDS       - chr6:401514-401515(+) m6A CDS       26404942 chr6:401540-401541(+) m6A CDS       26404942 chr6:401567-401568(+) m6A CDS       26404942 chr6:401585-401586(+) m6A CDS       26404942 chr6:401661-401662(+) m6A CDS       26404942 chr6:401724-401725(+) m6A CDS       26404942 chr6:401735-401736(+) m6A CDS       26404942 chr6:401740-401741(+) m6A CDS       26404942 chr6:405095-405096(+) m6A CDS       - chr6:406875-406876(+) m6A 3'UTR//intron       - chr6:407459-407460(+) m6A 3'UTR//CDS       26404942 chr6:407474-407475(+) m6A 3'UTR//CDS       26404942 chr6:407500-407501(+) m6A 3'UTR//CDS       26404942 chr6:407507-407508(+) m6A 3'UTR//CDS       26404942 chr6:407537-407538(+) m6A 3'UTR//CDS       26404942 chr6:407742-407743(+) m6A 3'UTR       26404942 chr6:407806-407807(+) m6A 3'UTR       26404942 chr6:407929-407930(+) m6A 3'UTR       25456834//26404942 chr6:408015-408016(+) m6A 3'UTR       26404942 chr6:408116-408117(+) m6A 3'UTR       26404942 chr6:408125-408126(+) m6A 3'UTR       26404942 chr6:408275-408276(+) m6A 3'UTR       - chr6:408439-408440(+) m6A 3'UTR       - chr6:408464-408465(+) m6A 3'UTR       - chr6:408488-408489(+) m6A 3'UTR       - chr6:408616-408617(+) m6A 3'UTR       26404942 chr6:408636-408637(+) m6A 3'UTR       26404942 chr6:408755-408756(+) m6A 3'UTR       - chr6:408782-408783(+) m6A 3'UTR       - chr6:408818-408819(+) m6A 3'UTR       - chr6:409622-409623(+) m6A 3'UTR       26404942 chr6:409636-409637(+) m6A 3'UTR       26404942 chr6:409717-409718(+) m6A 3'UTR       26404942 chr6:410087-410088(+) m6A 3'UTR       26404942 chr6:410142-410143(+) m6A 3'UTR       26404942 chr6:410168-410169(+) m6A 3'UTR       26404942 chr6:410191-410192(+) m6A 3'UTR       26404942 chr6:410292-410293(+) m6A 3'UTR       26404942 chr6:410321-410322(+) m6A 3'UTR       26404942 chr6:410333-410334(+) m6A 3'UTR       26404942 chr6:410362-410363(+) m6A 3'UTR       26404942 chr6:410392-410393(+) m6A 3'UTR       26404942 chr6:410419-410420(+) m6A 3'UTR       26404942 chr6:410429-410430(+) m6A 3'UTR       26404942 chr6:410443-410444(+) m6A 3'UTR       26404942 chr6:410454-410455(+) m6A 3'UTR       26404942 chr6:411030-411031(+) m6A 3'UTR       26404942 chr6:411128-411129(+) m6A 3'UTR       26404942 chr6:411134-411135(+) m6A 3'UTR       26404942 chr6:411143-411144(+) m6A 3'UTR       26404942 chr6:411211-411212(+) m6A 3'UTR       26404942 chr6:411227-411228(+) m6A 3'UTR       26404942

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	IRF4	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: IRF4

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.