Detail Information

Basic Information:


  VIRBase ID:  

VHID00503824

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           IRAK1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p IRAK1
miRBase
Accession/Entrez ID		 MIMAT0001581 3654
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - IRAK//pelle

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR IRAK1
chrX:153279602(-) A-I      NonSyn:His->Arg
chrX:153276588(-) A-I      3'UTR
chrX:153276744(-) A-I      3'UTR
chrX:153276791(-) A-I      3'UTR
chrX:153276814(-) A-I      3'UTR
chrX:153276750(-) A-I      3'UTR
chrX:153276813(-) A-I      3'UTR
chrX:153276668(-) A-I      3'UTR
chrX:153276687(-) A-I      3'UTR
chrX:153276787(-) A-I      3'UTR
chrX:153276634(-) A-I      3'UTR
chrX:153276650(-) A-I      3'UTR
chrX:153280137(-) A-I      intronic
chrX:153279877(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED IRAK1
chrX:153276566(-) A-G exon 3'UTR    22484847
chrX:153276668(-) A-G exon 3'UTR    22484847
chrX:153276687(-) A-G exon 3'UTR    22484847
chrX:153276787(-) A-G exon 3'UTR    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase IRAK1
chrX:153276155-153276156(-) m6A 3'UTR       22575960
chrX:153276172-153276173(-) m6A 3'UTR//exon       22575960
chrX:153276185-153276186(-) m6A 3'UTR//exon       22575960
chrX:153276230-153276231(-) m6A 3'UTR//exon       22575960
chrX:153276244-153276245(-) m6A 3'UTR//exon       22575960
chrX:153276407-153276408(-) m6A 3'UTR//CDS//intron       -
chrX:153276542-153276543(-) m6A 3'UTR//CDS//intron       27773535
chrX:153276562-153276563(-) m6A 3'UTR//CDS//intron       27773535
chrX:153276705-153276706(-) m6A 3'UTR//intron       24209618//22575960
chrX:153276733-153276734(-) m6A 3'UTR//intron       24284625//24209618//22575960
chrX:153276756-153276757(-) m6A 3'UTR//intron       24284625//24209618//22575960
chrX:153276912-153276913(-) m6A 3'UTR//intron       24284625//24209618//25456834//27371828//27773536//22608085
chrX:153277036-153277037(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960
chrX:153277128-153277129(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//27371828//27773536//22575960
chrX:153277349-153277350(-) m6A 3'UTR//CDS//intron       24284625//24209618//27773536//22575960
chrX:153277354-153277355(-) m6A 3'UTR//CDS//intron       24284625//24209618//27773536//22575960
chrX:153278014-153278015(-) m6A 3'UTR//CDS//intron       24284625//24209618//26404942//27773536//22575960
chrX:153278552-153278553(-) m6A 3'UTR//CDS//intron       24284625//27371828//27773536//22575960
chrX:153278591-153278592(-) m6A 3'UTR//CDS//intron       24284625//27371828//27773536//22575960
chrX:153278789-153278790(-) m6A 3'UTR//CDS//exon//intron       24284625//27371828//27773536
chrX:153279595-153279596(-) m6A 3'UTR//CDS//exon//intron       24284625//27371828//27773536
chrX:153279724-153279725(-) m6A 3'UTR//CDS//exon//intron       24284625//24981863//27371828//27773536
chrX:153279784-153279785(-) m6A exon//intron       24284625//24981863//27371828//27773536//22575960
chrX:153279792-153279793(-) m6A exon//intron       24284625//24981863//27371828//27773536//22575960
chrX:153279815-153279816(-) m6A exon//intron       24284625//24981863//27371828//27773536//22575960
chrX:153281493-153281494(-) m6A 3'UTR//CDS//exon//intron       24284625//24981863//27371828//27773536//22575960
chrX:153281535-153281536(-) m6A 3'UTR//CDS//exon//intron       24284625//27371828//27773536//22575960
chrX:153281906-153281907(-) m6A 3'UTR//CDS//exon//intron       24284625//27371828//27773536//22575960
chrX:153281912-153281913(-) m6A 3'UTR//CDS//exon//intron       24284625//27371828//27773536//22575960
chrX:153281976-153281977(-) m6A 3'UTR//CDS//exon//intron       24284625//27371828//27773536//22575960
chrX:153281982-153281983(-) m6A 3'UTR//CDS//exon//intron       24284625//27371828//27773536//22575960
chrX:153282050-153282051(-) m6A 3'UTR//CDS//exon//intron       24284625//27773536//22575960
chrX:153282408-153282409(-) m6A CDS//exon//intron       24284625//27773536//22575960
chrX:153282432-153282433(-) m6A CDS//exon//intron       24284625//27773536//22575960
chrX:153282477-153282478(-) m6A CDS//exon//intron       24284625//27773536//22575960
chrX:153283472-153283473(-) m6A CDS//exon//intron       24284625//27773536//22575960
chrX:153283547-153283548(-) m6A CDS//exon//intron       24284625//27773536//22575960
chrX:153283556-153283557(-) m6A CDS//exon//intron       24284625//27773536//22575960
chrX:153283787-153283788(-) m6A CDS//exon//intron       24284625//27773536//22575960
chrX:153284080-153284081(-) m6A CDS//exon//intron       24284625//22575960
chrX:153284129-153284130(-) Am CDS//exon//intron       -
chrX:153284268-153284269(-) m6A exon//intron       24284625
chrX:153284274-153284275(-) m6A exon//intron       24284625
chrX:153284390-153284391(-) m6A exon//intron       24284625
chrX:153284511-153284512(-) m6A CDS       24284625//27773536//22575960
chrX:153284895-153284896(-) m6A CDS       24284625//27773536//22575960
chrX:153285025-153285026(-) m6A CDS       24284625//27773536//22575960
chrX:153285336-153285337(-) m6A 5'UTR       24209618//24981863//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate IRAK1
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: IRAK1

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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