Detail Information

Basic Information:


  VIRBase ID:  

VHID00503821

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           EIF3E:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p EIF3E
miRBase
Accession/Entrez ID		 MIMAT0001581 3646
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - eIF3-p46//EIF3-P48//EIF3S6//INT6

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR EIF3E
chr8:109238581(-) A-I      intronic
chr8:109238600(-) A-I      intronic
chr8:109246479(-) A-I      intronic
chr8:109232290(-) A-I      intronic
chr8:109238547(-) A-I      intronic
chr8:109231209(-) A-I      intronic
chr8:109231018(-) A-I      intronic
chr8:109231080(-) A-I      intronic
chr8:109231141(-) A-I      intronic
chr8:109231145(-) A-I      intronic
chr8:109238603(-) A-I      intronic
chr8:109231265(-) A-I      intronic
chr8:109239351(-) A-I      intronic
chr8:109239337(-) A-I      intronic
chr8:109238602(-) A-I      intronic
chr8:109249034(-) A-I      intronic
chr8:109249094(-) A-I      intronic
chr8:109249534(-) A-I      intronic
chr8:109231228(-) A-I      intronic
chr8:109249006(-) A-I      intronic
chr8:109249007(-) A-I      intronic
chr8:109249592(-) A-I      intronic
chr8:109249645(-) A-I      intronic
chr8:109249657(-) A-I      intronic
chr8:109249754(-) A-I      intronic
chr8:109232206(-) A-I      intronic
chr8:109239336(-) A-I      intronic
chr8:109239333(-) A-I      intronic
chr8:109238662(-) A-I      intronic
chr8:109238643(-) A-I      intronic
chr8:109249737(-) A-I      intronic
chr8:109238534(-) A-I      intronic
chr8:109238520(-) A-I      intronic
chr8:109238490(-) A-I      intronic
chr8:109238465(-) A-I      intronic
chr8:109234428(-) A-I      intronic
chr8:109233495(-) A-I      intronic
chr8:109239431(-) A-I      intronic
chr8:109238606(-) A-I      intronic
chr8:109232215(-) A-I      intronic
chr8:109249659(-) A-I      intronic
chr8:109231177(-) A-I      intronic
chr8:109245813(-) A-I      intronic
chr8:109231144(-) A-I      intronic
chr8:109238612(-) A-I      intronic
chr8:109257638(-) A-I      intronic
chr8:109231985(-) A-I      intronic
chr8:109246399(-) A-I      intronic
chr8:109246431(-) A-I      intronic
chr8:109257651(-) A-I      intronic
chr8:109232347(-) A-I      intronic
chr8:109231216(-) A-I      intronic
chr8:109246426(-) A-I      intronic
chr8:109231908(-) A-I      intronic
chr8:109249660(-) A-I      intronic
chr8:109239444(-) A-I      intronic
chr8:109234403(-) A-I      intronic
chr8:109249543(-) A-I      intronic
chr8:109249168(-) A-I      intronic
chr8:109249675(-) A-I      intronic
chr8:109233127(-) A-I      intronic
chr8:109232250(-) A-I      intronic
chr8:109231084(-) A-I      intronic
chr8:109232289(-) A-I      intronic
chr8:109249194(-) A-I      intronic
chr8:109249175(-) A-I      intronic
chr8:109246329(-) A-I      intronic
chr8:109233422(-) A-I      intronic
chr8:109249085(-) A-I      intronic
chr8:109251522(-) A-I      intronic
chr8:109231218(-) A-I      intronic
chr8:109231884(-) A-I      intronic
chr8:109239382(-) A-I      intronic
chr8:109231101(-) A-I      intronic
chr8:109232200(-) A-I      intronic
chr8:109224993(-) A-I      intronic
chr8:109231151(-) A-I      intronic
chr8:109249618(-) A-I      intronic
chr8:109245949(-) A-I      intronic
chr8:109239470(-) A-I      intronic
chr8:109249514(-) A-I      intronic
chr8:109239491(-) A-I      intronic
chr8:109239445(-) A-I      intronic
chr8:109249753(-) A-I      intronic
chr8:109232303(-) A-I      intronic
chr8:109249619(-) A-I      intronic
chr8:109249059(-) A-I      intronic
chr8:109249151(-) A-I      intronic
chr8:109234343(-) A-I      intronic
chr8:109238698(-) A-I      intronic
chr8:109234314(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED EIF3E
chr8:109231101(-) A-G intron -    22484847
chr8:109231151(-) A-G intron -    22484847
chr8:109231216(-) A-G intron -    22484847
chr8:109231287(-) A-G intron -    22484847
chr8:109231888(-) A-G intron -    22484847
chr8:109231908(-) A-G intron -    22484847
chr8:109232289(-) A-G intron -    22484847
chr8:109232303(-) A-G intron -    22484847
chr8:109232374(-) G-T intron -    22484847
chr8:109249059(-) A-G intron -    22484847
chr8:109249071(-) A-G intron -    22484847
chr8:109249085(-) A-G intron -    22484847
chr8:109249088(-) A-G intron -    22484847
chr8:109249151(-) A-G intron -    22484847
chr8:109249168(-) A-G intron -    22484847
chr8:109249175(-) A-G intron -    22484847
chr8:109249245(-) A-G intron -    22484847
chr8:109249659(-) A-G intron -    22484847
chr8:109249660(-) A-G intron -    22484847
chr8:109249675(-) A-G intron -    22484847
chr8:109249732(-) A-G intron -    22484847
chr8:109249753(-) A-G intron -    22484847
chr8:109249767(-) A-G intron -    22484847
chr8:109253183(-) G-A intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase EIF3E
chr8:109213705-109213706(-) m6A exon       27773535
chr8:109214023-109214024(-) m6A 3'UTR//exon       24981863//28052920//27773535//22608085
chr8:109214056-109214057(-) m6A 3'UTR//exon       24981863//28052920//27773535//22608085
chr8:109214083-109214084(-) m6A 3'UTR//exon       24981863//28052920//27773535//22608085
chr8:109214109-109214110(-) m6A 3'UTR//exon       24981863//27773535
chr8:109215235-109215236(-) m6A CDS//exon       24981863//27773535
chr8:109215288-109215289(-) m6A CDS//exon       24981863
chr8:109228722-109228723(-) m6A CDS//exon//intron       26404942
chr8:109229620-109229621(-) m6A 3'UTR//CDS//exon//intron       26404942
chr8:109229669-109229670(-) m6A 3'UTR//CDS//exon//intron       26404942
chr8:109233728-109233729(-) m6A exon//intron       26404942
chr8:109240583-109240584(-) m6A 3'UTR//CDS//exon       27773535
chr8:109241312-109241313(-) m6A 3'UTR//CDS//exon       27773535
chr8:109241320-109241321(-) Y 3'UTR//CDS//exon       26075521
chr8:109241332-109241333(-) m6A 3'UTR//CDS//exon       -
chr8:109255686-109255687(-) m6A 5'UTR//intron       24981863
chr8:109260950-109260951(-) m6A 5'UTR//exon//intron       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate EIF3E
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Membrane K562 cells     -
Nucleoplasm K562 cells     -
Nucleus K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome-free cytosol Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: EIF3E

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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