Detail Information

Basic Information:


  VIRBase ID:  

VHID00503796

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           IMPDH1:      

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Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p IMPDH1
miRBase
Accession/Entrez ID		 MIMAT0001581 3614
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - IMPD//IMPD1//IMPDH-I//LCA11//RP10//sWSS2608

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR IMPDH1
chr7:128043512(-) A-I      intronic
chr7:128043529(-) A-I      intronic
chr7:128043420(-) A-I      intronic
chr7:128032412(-) A-I      3'UTR
chr7:128032420(-) A-I      3'UTR
chr7:128032372(-) A-I      3'UTR
chr7:128032391(-) A-I      3'UTR
chr7:128032393(-) A-I      3'UTR
chr7:128032375(-) A-I      3'UTR
chr7:128032413(-) A-I      3'UTR
chr7:128043394(-) A-I      intronic
chr7:128042253(-) A-I      intronic
chr7:128042294(-) A-I      intronic
chr7:128042350(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase IMPDH1
chr7:128032451-128032452(-) m6A 3'UTR       24284625
chr7:128032509-128032510(-) m6A 3'UTR       24284625
chr7:128032871-128032872(-) m6A 3'UTR       24284625
chr7:128032909-128032910(-) m6A 3'UTR       24284625
chr7:128034374-128034375(-) m6A 3'UTR//CDS//exon       27773535
chr7:128034602-128034603(-) m6A 3'UTR//CDS//exon       24981863//27773535
chr7:128034748-128034749(-) m6A exon//intron       27773535//27371828
chr7:128035221-128035222(-) m6A 3'UTR//CDS//exon       22575960
chr7:128035229-128035230(-) m6A 3'UTR//CDS       22575960
chr7:128038591-128038592(-) m6A 3'UTR//CDS//exon       -
chr7:128038597-128038598(-) m6A 3'UTR//CDS//exon       -
chr7:128040215-128040216(-) m6A 3'UTR//CDS//exon       -
chr7:128041105-128041106(-) m6A 3'UTR//CDS//exon       24284625
chr7:128043778-128043779(-) m6A 3'UTR//CDS//exon       24284625//22575960
chr7:128045910-128045911(-) m6A 3'UTR//CDS//exon//intron       24284625//27371828//27773536//22575960
chr7:128049526-128049527(-) m6A 5'UTR//CDS//exon//intron       27371828//27773536
chr7:128049871-128049872(-) m6A 5'UTR//CDS//exon       24981863//27371828//27773536
chr7:128050035-128050036(-) m6A 5'UTR//exon       24981863//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate IMPDH1
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: IMPDH1

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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