Basic Information:

  VIRBase ID:  

VHID00503767

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          CXCL8:  NM_000584     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	CXCL8
miRBase Accession/Entrez ID	MIMAT0001581	3576
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	GCP-1//GCP1//IL8//LECT//LUCT//LYNAP//MDNCF//MONAP//NAF//NAP-1//NAP1//SCYB8

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CXCL8	chr4:74606289-74606290(+) m6A 5'UTR//exon       24981863//26404942 chr4:74606299-74606300(+) m6A 5'UTR//exon       24981863//26404942 chr4:74606324-74606325(+) m6A 5'UTR//exon       24981863//26404942//27773535 chr4:74606341-74606342(+) m6A 5'UTR//exon       24981863//26404942//27773535 chr4:74606354-74606355(+) m6A 5'UTR//exon       24981863//26404942//27773535 chr4:74606373-74606374(+) m6A 5'UTR//exon       24981863//26404942//27773535 chr4:74607286-74607287(+) m6A CDS//exon       27773535 chr4:74607308-74607309(+) m6A CDS//exon       27773535 chr4:74607319-74607320(+) m6A CDS//exon       26404942//27773535 chr4:74607346-74607347(+) m6A CDS//exon       26404942//27773535 chr4:74607367-74607368(+) m6A CDS//exon       26404942//27773535 chr4:74607434-74607435(+) m6A exon//intron       26404942 chr4:74608331-74608332(+) m6A 3'UTR       27773535 chr4:74608370-74608371(+) m6A 3'UTR       27773535 chr4:74608413-74608414(+) m6A 3'UTR       27773535 chr4:74608510-74608511(+) m6A 3'UTR       26404942//27773535 chr4:74608579-74608580(+) m6A 3'UTR       26404942//27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	CXCL8	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: CXCL8

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.