Basic Information:

  VIRBase ID:  

VHID00503755

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          IL2RG:  NM_000206     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	IL2RG
miRBase Accession/Entrez ID	MIMAT0001581	3561
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	CD132//CIDX//IL-2RG//IMD4//P64//SCIDX//SCIDX1

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	IL2RG	chrX:70327292-70327293(-) m6A 3'UTR//exon       28052920//27773535 chrX:70327398-70327399(-) m6A 3'UTR//exon       28052920//27773535 chrX:70327562-70327563(-) m6A 3'UTR//exon       26404942//27773535 chrX:70327584-70327585(-) m6A 3'UTR//exon       26404942//27773535 chrX:70327590-70327591(-) m6A 3'UTR//CDS//exon       26404942//27773535 chrX:70327962-70327963(-) m6A exon//intron       27371828 chrX:70327977-70327978(-) m6A exon//intron       27371828 chrX:70328066-70328067(-) m6A exon//intron       - chrX:70329237-70329238(-) m6A 5'UTR//CDS//exon       26404942 chrX:70330007-70330008(-) m6A 5'UTR//CDS//exon//intron       26404942 chrX:70330018-70330019(-) m6A 5'UTR//CDS//exon//intron       26404942 chrX:70330028-70330029(-) m6A 5'UTR//CDS//exon//intron       26404942 chrX:70330060-70330061(-) m6A 5'UTR//CDS//exon//intron       26404942 chrX:70330075-70330076(-) m6A 5'UTR//CDS//exon//intron       26404942 chrX:70330081-70330082(-) m6A 5'UTR//CDS//exon//intron       26404942 chrX:70330086-70330087(-) m6A 5'UTR//CDS//exon//intron       26404942 chrX:70330107-70330108(-) m6A 5'UTR//CDS//exon//intron       26404942 chrX:70330123-70330124(-) m6A 5'UTR//CDS//exon//intron       26404942 chrX:70330980-70330981(-) m6A 5'UTR//exon//intron       27773535//27371828 chrX:70331259-70331260(-) m6A 5'UTR//CDS//exon//intron       27371828 chrX:70331285-70331286(-) m6A 5'UTR//CDS//exon       26404942//27371828 chrX:70331318-70331319(-) m6A 5'UTR//CDS//exon       28052920//26404942//27371828 chrX:70331422-70331423(-) m6A 5'UTR//exon//intron       28052920//26404942//27371828 chrX:70331441-70331442(-) m6A 5'UTR//exon//intron       28052920//26404942//27371828 chrX:70331944-70331945(-) m6A 5'UTR       27371828

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	IL2RG	Cytosol K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: IL2RG

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.