Basic Information:

  VIRBase ID:  

VHID00503754

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          IL2RB:  NM_000878     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	IL2RB
miRBase Accession/Entrez ID	MIMAT0001581	3560
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	CD122//IL15RB//IMD63//P70-75

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	IL2RB	chr22:37527914(-) A-I      intronic chr22:37534094(-) A-I      intronic chr22:37528046(-) A-I      intronic chr22:37527915(-) A-I      intronic chr22:37527837(-) A-I      intronic chr22:37526950(-) A-I      intronic chr22:37527144(-) A-I      intronic chr22:37527082(-) A-I      intronic chr22:37527125(-) A-I      intronic chr22:37527955(-) A-I      intronic chr22:37527176(-) A-I      intronic chr22:37527024(-) A-I      intronic chr22:37527954(-) A-I      intronic chr22:37527873(-) A-I      intronic chr22:37527098(-) A-I      intronic chr22:37527095(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	IL2RB	chr22:37527098(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	IL2RB	chr22:37522465-37522466(-) m6A 3'UTR       28052920 chr22:37522501-37522502(-) m6A 3'UTR       28052920 chr22:37523654-37523655(-) m6A 3'UTR       28052920 chr22:37523688-37523689(-) m6A 3'UTR       28052920 chr22:37524619-37524620(-) m6A CDS//exon       - chr22:37539596-37539597(-) m6A CDS//exon       27371828 chr22:37545904-37545905(-) m6A 5'UTR//intron       27371828 chr22:37557862-37557863(-) m6A 5'UTR//intron       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	IL2RB	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: IL2RB

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.