Basic Information:

  VIRBase ID:  

VHID00503749

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          IL1R1:  NM_001320981     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	IL1R1
miRBase Accession/Entrez ID	MIMAT0001581	3554
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	CD121A//D2S1473//IL-1R-alpha//IL1R//IL1RA//P80

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	IL1R1	chr2:102793548(+) A-I      3'UTR chr2:102793509(+) A-I      3'UTR chr2:102793567(+) A-I      3'UTR chr2:102793573(+) A-I      3'UTR chr2:102793575(+) A-I      3'UTR chr2:102793535(+) A-I      3'UTR chr2:102793540(+) A-I      3'UTR chr2:102793542(+) A-I      3'UTR chr2:102787460(+) A-I      intronic chr2:102787446(+) A-I      intronic chr2:102787498(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	IL1R1	chr2:102686953-102686954(+) m6A 5'UTR//intron       24981863 chr2:102721072-102721073(+) m6A 5'UTR//intron       24981863 chr2:102721154-102721155(+) m6A 5'UTR//intron       24981863 chr2:102791951-102791952(+) m6A 3'UTR//CDS//intron       24981863 chr2:102791981-102791982(+) m6A 3'UTR//CDS//intron       24981863 chr2:102792052-102792053(+) m6A 3'UTR//CDS//intron       24981863 chr2:102792812-102792813(+) m6A 3'UTR//CDS//intron       24981863 chr2:102792855-102792856(+) m6A 3'UTR//CDS//intron       24981863 chr2:102792880-102792881(+) m6A 3'UTR//CDS//intron       24981863 chr2:102792992-102792993(+) m6A 3'UTR//CDS//intron       24981863 chr2:102793035-102793036(+) m6A 3'UTR//CDS//intron       24981863 chr2:102793061-102793062(+) m6A 3'UTR//CDS//intron       24981863 chr2:102793074-102793075(+) m6A 3'UTR//CDS//intron       24981863 chr2:102793090-102793091(+) m6A 3'UTR//CDS//intron       24981863//26404942 chr2:102793152-102793153(+) m6A 3'UTR//CDS//intron       24981863//26404942 chr2:102793185-102793186(+) m6A 3'UTR//CDS//intron       24981863 chr2:102793761-102793762(+) m6A 3'UTR       24981863 chr2:102793783-102793784(+) m6A 3'UTR       24981863 chr2:102793790-102793791(+) m6A 3'UTR       24981863 chr2:102793885-102793886(+) m6A 3'UTR       24981863 chr2:102793945-102793946(+) m6A 3'UTR       24981863 chr2:102793970-102793971(+) m6A 3'UTR       24981863 chr2:102793985-102793986(+) m6A 3'UTR       24981863 chr2:102795787-102795788(+) m6A 3'UTR       24981863//26404942//27773535 chr2:102795827-102795828(+) m6A 3'UTR       24981863//26404942 chr2:102795884-102795885(+) m6A 3'UTR       24981863 chr2:102795906-102795907(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	IL1R1	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: IL1R1

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.