Basic Information:
VIRBase ID: VHID00503738
Virus: Human herpesvirus 5 strain AD169
Host: Homo sapiens
Confidence Score: 0.7311
Interaction Type: Virus-Host interaction
Predicted Binding:
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Interactor Information:
Interactor1
Interactor2
Symbol
hcmv-miR-US25-1-5p
CCN1
miRBase Accession/Entrez ID
MIMAT0001581
3491
Organism
Human herpesvirus 5 strain AD169
Homo sapiens
Category
miRNA
mRNA
Alias
-
CYR61//GIG1//IGFBP10
RNA Editing:
Resource
Symbol
Editing Position
Change
Genetic Region
RADAR
CCN1
RNA Localization:
Resource
Symbol
Subcellular Localization
Tissue or Cell Line
PMID
RNALocate
CCN1
Interaction Network (The top 100 interactions) :
Interactor1: hcmv-miR-US25-1-5p
Interactor2: CCN1
Evidence Support:
Strong-Evidence
RISC-IP
Support Database
ViRBase
References:
PMID
20585629
Target region
5'UTR
Source
ViRBase
Interactor1 expression
None
Tissue or cell line
HEK293 cells
Interactor2 expression
None
Description
Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.