Basic Information:

  VIRBase ID:  

VHID00503718

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          IFNAR2:  NM_001289126     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	IFNAR2
miRBase Accession/Entrez ID	MIMAT0001581	3455
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	IFN-alpha-REC//IFN-R//IFNABR//IFNARB//IMD45

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	IFNAR2	chr21:34615537(+) A-I      intronic chr21:34615553(+) A-I      intronic chr21:34634870(+) A-I      NonSyn:Gln->Arg chr21:34634993(+) A-I      NonSyn:Lys->Arg chr21:34634881(+) A-I      NonSyn:Lys->Glu chr21:34637281(+) A-I      3'UTR chr21:34637136(+) A-I      3'UTR chr21:34637065(+) A-I      3'UTR chr21:34634980(+) A-I      NonSyn:Ser->Gly chr21:34604212(+) A-I      intronic chr21:34637181(+) A-I      3'UTR chr21:34615235(+) A-I      intronic chr21:34615220(+) A-I      intronic chr21:34634619(+) A-I      intronic chr21:34634610(+) A-I      intronic chr21:34634589(+) A-I      intronic chr21:34634580(+) A-I      intronic chr21:34634469(+) A-I      intronic chr21:34634133(+) A-I      intronic chr21:34634038(+) A-I      intronic chr21:34624313(+) A-I      intronic chr21:34624238(+) A-I      intronic chr21:34624217(+) A-I      intronic chr21:34609680(+) A-I      intronic chr21:34615173(+) A-I      intronic chr21:34614884(+) A-I      intronic chr21:34608110(+) A-I      intronic chr21:34615193(+) A-I      intronic chr21:34615412(+) A-I      intronic chr21:34615549(+) A-I      intronic chr21:34634856(+) A-I      intronic chr21:34624295(+) A-I      intronic chr21:34622969(+) A-I      intronic chr21:34622982(+) A-I      intronic chr21:34623000(+) A-I      intronic chr21:34624154(+) A-I      intronic chr21:34624163(+) A-I      intronic chr21:34624211(+) A-I      intronic chr21:34614959(+) A-I      intronic chr21:34614923(+) A-I      intronic chr21:34614958(+) A-I      intronic chr21:34608116(+) A-I      intronic chr21:34637207(+) A-I      3'UTR chr21:34637142(+) A-I      3'UTR chr21:34636426(+) A-I      3'UTR chr21:34636386(+) A-I      3'UTR chr21:34637022(+) A-I      3'UTR chr21:34637061(+) A-I      3'UTR chr21:34637165(+) A-I      3'UTR chr21:34637087(+) A-I      3'UTR chr21:34637116(+) A-I      3'UTR chr21:34637278(+) A-I      3'UTR chr21:34637098(+) A-I      3'UTR chr21:34636393(+) A-I      3'UTR chr21:34637241(+) A-I      3'UTR chr21:34637095(+) A-I      3'UTR chr21:34637137(+) A-I      3'UTR chr21:34636399(+) A-I      3'UTR chr21:34637205(+) A-I      3'UTR chr21:34637115(+) A-I      3'UTR chr21:34636239(+) A-I      3'UTR chr21:34637110(+) A-I      3'UTR chr21:34637245(+) A-I      3'UTR chr21:34636349(+) A-I      3'UTR chr21:34636344(+) A-I      3'UTR chr21:34636351(+) A-I      3'UTR chr21:34637108(+) A-I      3'UTR chr21:34636215(+) A-I      3'UTR chr21:34637266(+) A-I      3'UTR chr21:34636328(+) A-I      3'UTR chr21:34636319(+) A-I      3'UTR chr21:34636353(+) A-I      3'UTR chr21:34637198(+) A-I      3'UTR chr21:34637251(+) A-I      3'UTR chr21:34636316(+) A-I      3'UTR chr21:34637192(+) A-I      3'UTR chr21:34637150(+) A-I      3'UTR chr21:34636305(+) A-I      3'UTR chr21:34636242(+) A-I      3'UTR chr21:34637224(+) A-I      3'UTR chr21:34634968(+) A-I      NonSyn:Ser->Gly chr21:34637185(+) A-I      3'UTR chr21:34636425(+) A-I      3'UTR chr21:34636364(+) A-I      3'UTR chr21:34636179(+) A-I      3'UTR chr21:34615194(+) A-I      intronic chr21:34615353(+) A-I      intronic chr21:34634439(+) A-I      intronic chr21:34633468(+) A-I      intronic chr21:34633965(+) A-I      intronic chr21:34604186(+) A-I      intronic chr21:34615367(+) A-I      intronic chr21:34604250(+) A-I      intronic chr21:34621518(+) A-I      intronic chr21:34633981(+) A-I      intronic chr21:34634050(+) A-I      intronic chr21:34615018(+) A-I      intronic chr21:34620550(+) A-I      intronic chr21:34614850(+) A-I      intronic chr21:34614782(+) A-I      intronic chr21:34621581(+) A-I      intronic chr21:34604227(+) A-I      intronic chr21:34615233(+) A-I      intronic chr21:34614891(+) A-I      intronic chr21:34615631(+) A-I      intronic chr21:34612870(+) A-I      intronic chr21:34615356(+) A-I      intronic chr21:34633542(+) A-I      intronic chr21:34612931(+) A-I      intronic chr21:34613077(+) A-I      intronic chr21:34633604(+) A-I      intronic chr21:34604224(+) A-I      intronic chr21:34633467(+) A-I      intronic chr21:34622861(+) A-I      intronic chr21:34613040(+) A-I      intronic chr21:34615198(+) A-I      intronic chr21:34634447(+) A-I      intronic chr21:34634486(+) A-I      intronic chr21:34634438(+) A-I      intronic chr21:34630590(+) A-I      intronic chr21:34634443(+) A-I      intronic chr21:34634514(+) A-I      intronic chr21:34633483(+) A-I      intronic chr21:34637140(+) A-I      3'UTR chr21:34637216(+) A-I      3'UTR chr21:34636385(+) A-I      3'UTR chr21:34636204(+) A-I      3'UTR chr21:34636260(+) A-I      3'UTR chr21:34636253(+) A-I      3'UTR chr21:34636259(+) A-I      3'UTR chr21:34637079(+) A-I      3'UTR chr21:34637145(+) A-I      3'UTR chr21:34636203(+) A-I      3'UTR chr21:34637159(+) A-I      3'UTR chr21:34636293(+) A-I      3'UTR chr21:34637246(+) A-I      3'UTR chr21:34637144(+) A-I      3'UTR chr21:34637208(+) A-I      3'UTR chr21:34636181(+) A-I      3'UTR chr21:34637084(+) A-I      3'UTR chr21:34637093(+) A-I      3'UTR chr21:34637237(+) A-I      3'UTR chr21:34636183(+) A-I      3'UTR chr21:34637149(+) A-I      3'UTR chr21:34637146(+) A-I      3'UTR chr21:34633947(+) A-I      intronic chr21:34608044(+) A-I      intronic chr21:34604281(+) A-I      intronic chr21:34609693(+) A-I      intronic chr21:34612862(+) A-I      intronic chr21:34622898(+) A-I      intronic chr21:34612914(+) A-I      intronic chr21:34613000(+) A-I      intronic chr21:34615376(+) A-I      intronic chr21:34614783(+) A-I      intronic chr21:34615408(+) A-I      intronic chr21:34623124(+) A-I      intronic chr21:34615114(+) A-I      intronic chr21:34604147(+) A-I      intronic chr21:34614888(+) A-I      intronic chr21:34634414(+) A-I      intronic chr21:34615303(+) A-I      intronic chr21:34615163(+) A-I      intronic chr21:34604071(+) A-I      intronic chr21:34612871(+) A-I      intronic chr21:34615514(+) A-I      intronic chr21:34615428(+) A-I      intronic chr21:34614881(+) A-I      intronic chr21:34612988(+) A-I      intronic chr21:34633435(+) A-I      intronic chr21:34634395(+) A-I      intronic chr21:34612990(+) A-I      intronic chr21:34609729(+) A-I      intronic chr21:34612929(+) A-I      intronic chr21:34615572(+) A-I      intronic chr21:34623033(+) A-I      intronic chr21:34633422(+) A-I      intronic chr21:34613101(+) A-I      intronic chr21:34609719(+) A-I      intronic chr21:34633999(+) A-I      intronic chr21:34633551(+) A-I      intronic chr21:34615284(+) A-I      intronic chr21:34613014(+) A-I      intronic chr21:34634122(+) A-I      intronic chr21:34615283(+) A-I      intronic chr21:34604254(+) A-I      intronic chr21:34621528(+) A-I      intronic chr21:34615662(+) A-I      intronic chr21:34623118(+) A-I      intronic chr21:34612973(+) A-I      intronic chr21:34615016(+) A-I      intronic chr21:34621394(+) A-I      intronic chr21:34633411(+) A-I      intronic chr21:34634034(+) A-I      intronic chr21:34604072(+) A-I      intronic chr21:34615021(+) A-I      intronic chr21:34615126(+) A-I      intronic chr21:34615617(+) A-I      intronic chr21:34623087(+) A-I      intronic chr21:34634042(+) A-I      intronic chr21:34612985(+) A-I      intronic chr21:34621569(+) A-I      intronic chr21:34614917(+) A-I      intronic chr21:34615563(+) A-I      intronic chr21:34634952(+) A-I      Syn:Lys->Lys chr21:34634882(+) A-I      NonSyn:Lys->Arg

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	IFNAR2	chr21:34621070(+) A-I exon CDS    15342557 chr21:34636203(+) A-I exon 3'UTR    15258596 chr21:34636234(+) A-I exon 3'UTR    15342557   //15258596 chr21:34636253(+) A-I exon 3'UTR    15342557   //15258596   //22327324 chr21:34636259(+) A-I exon 3'UTR    15342557   //15258596   //22327324 chr21:34636260(+) A-I exon 3'UTR    15342557   //15258596   //22327324 chr21:34636347(+) A-I exon 3'UTR    15258596 chr21:34636361(+) A-I exon 3'UTR    15342557   //15258596 chr21:34636384(+) A-I exon 3'UTR    15342557   //15258596   //22327324 chr21:34604071(+) A-I intron -    21960545   //22327324 chr21:34612928(+) A-I intron -    22327324 chr21:34612933(+) A-I intron -    22327324 chr21:34612973(+) A-I intron -    22327324 chr21:34612990(+) A-I intron -    22327324 chr21:34613040(+) A-I intron -    22327324 chr21:34636204(+) A-I intron -    22327324 chr21:34636293(+) A-I intron -    22327324 chr21:34636303(+) A-I intron -    22327324 chr21:34636385(+) A-I intron -    22327324 chr21:34604072(+) A-I intron -    21960545 chr21:34604127(+) A-I intron -    21960545 chr21:34604181(+) A-I intron -    21960545 chr21:34604250(+) A-I intron -    21960545 chr21:34612929(+) A-I intron -    21960545 chr21:34631036(+) A-I intron -    21960545 chr21:34604071(+) A-G intron -    22484847 chr21:34604072(+) A-G intron -    22484847 chr21:34604188(+) A-G intron -    22484847 chr21:34604224(+) A-G intron -    22484847 chr21:34604227(+) A-G intron -    22484847 chr21:34604250(+) A-G intron -    22484847 chr21:34604281(+) A-G intron -    22484847 chr21:34604313(+) A-G intron -    22484847 chr21:34608044(+) A-G intron -    22484847 chr21:34609760(+) A-G intron -    22484847 chr21:34609765(+) A-G intron -    22484847 chr21:34612928(+) A-G intron -    22484847 chr21:34612929(+) A-G intron -    22484847 chr21:34612931(+) A-G intron -    22484847 chr21:34612933(+) A-G intron -    22484847 chr21:34612973(+) A-G intron -    22484847 chr21:34612988(+) A-G intron -    22484847 chr21:34612990(+) A-G intron -    22484847 chr21:34613040(+) A-G intron -    22484847 chr21:34613119(+) C-A intron -    22484847 chr21:34615578(+) A-G intron -    22484847 chr21:34615650(+) A-G intron -    22484847 chr21:34620550(+) A-G intron -    22484847 chr21:34633399(+) T-C intron -    22484847 chr21:34633965(+) A-G intron -    22484847 chr21:34634074(+) A-G intron -    22484847 chr21:34634122(+) A-G intron -    22484847 chr21:34634176(+) A-G intron -    22484847 chr21:34634395(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	IFNAR2	chr21:34635049-34635050(+) m6A 3'UTR//intron       - chr21:34635067-34635068(+) m6A 3'UTR//intron       - chr21:34635250-34635251(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:34635279-34635280(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:34635338-34635339(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:34635404-34635405(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:34635423-34635424(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:34635467-34635468(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:34635485-34635486(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:34635533-34635534(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:34635539-34635540(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:34635572-34635573(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:34635659-34635660(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:34635685-34635686(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:34635812-34635813(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr21:34635824-34635825(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr21:34635830-34635831(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr21:34635919-34635920(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr21:34635975-34635976(+) m6A 3'UTR       24981863//22608085 chr21:34636350-34636351(+) m6A 3'UTR       24209618 chr21:34636385-34636386(+) m6A 3'UTR       24209618 chr21:34636610-34636611(+) m6A 3'UTR       24209618//24981863//27773535 chr21:34636729-34636730(+) m6A 3'UTR       24209618//24981863 chr21:34636770-34636771(+) m6A 3'UTR       24981863//27773535 chr21:34636795-34636796(+) m6A 3'UTR       24981863//27773535 chr21:34636835-34636836(+) m6A 3'UTR       24981863//27773535 chr21:34636888-34636889(+) m6A 3'UTR       24209618//24981863//27773535 chr21:34637062-34637063(+) m6A 3'UTR       - chr21:34637094-34637095(+) m6A 3'UTR       - chr21:34637131-34637132(+) m6A 3'UTR       - chr21:34637352-34637353(+) m6A 3'UTR       24284625 chr21:34637358-34637359(+) m6A 3'UTR       24284625 chr21:34637458-34637459(+) m6A 3'UTR       24981863//22608085 chr21:34637484-34637485(+) m6A 3'UTR       24981863//22608085 chr21:34637519-34637520(+) m6A 3'UTR       24981863//22608085 chr21:34637578-34637579(+) m6A 3'UTR       24981863//22608085 chr21:34637624-34637625(+) m6A 3'UTR       24981863 chr21:34637656-34637657(+) m6A 3'UTR       24981863//26404942 chr21:34637686-34637687(+) m6A 3'UTR       24981863//26404942 chr21:34637741-34637742(+) m6A 3'UTR       26404942

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	IFNAR2	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: IFNAR2

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.