Basic Information:

  VIRBase ID:  

VHID00503703

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          IFIT3:  NM_001289759     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	IFIT3
miRBase Accession/Entrez ID	MIMAT0001581	3437
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	CIG-49//cig41//GARG-49//IFI60//IFIT4//IRG2//ISG60//P60//RIG-G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	IFIT3	chr10:91100152(+) A-I      3'UTR chr10:91100128(+) A-I      3'UTR chr10:91100161(+) A-I      3'UTR chr10:91100132(+) A-I      3'UTR chr10:91100172(+) A-I      3'UTR chr10:91100158(+) A-I      3'UTR chr10:91100153(+) A-I      3'UTR chr10:91095784(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	IFIT3	chr10:91087689-91087690(+) m6A 5'UTR       24981863 chr10:91087757-91087758(+) m6A 5'UTR       24981863 chr10:91087765-91087766(+) m6A 5'UTR       24981863 chr10:91087776-91087777(+) m6A 5'UTR       24981863 chr10:91087806-91087807(+) m6A 5'UTR       24981863 chr10:91087815-91087816(+) m6A 5'UTR       24981863 chr10:91092268-91092269(+) m6A 5'UTR//intron       24981863 chr10:91092291-91092292(+) m6A 5'UTR//intron       24981863 chr10:91092359-91092360(+) m6A 5'UTR//intron       - chr10:91092370-91092371(+) m6A 5'UTR//intron       - chr10:91098479-91098480(+) m6A CDS       - chr10:91098494-91098495(+) m6A CDS       - chr10:91098548-91098549(+) m6A CDS       - chr10:91098594-91098595(+) m6A CDS       - chr10:91098663-91098664(+) m6A CDS       24981863//27773535//22575960 chr10:91098707-91098708(+) m6A CDS       24981863//27773535//22575960 chr10:91098738-91098739(+) m6A CDS       24981863//27773535//22575960 chr10:91098774-91098775(+) m6A CDS       24209618//24981863//27773535//22575960 chr10:91098822-91098823(+) m6A CDS       24209618//25456834//24981863//27773535//22575960 chr10:91098844-91098845(+) m6A CDS       24209618//25456834//24981863//27773535//22575960 chr10:91098936-91098937(+) m6A CDS       24209618//24981863//27773535//22575960 chr10:91098978-91098979(+) m6A CDS       24209618//24981863//22575960 chr10:91099059-91099060(+) m6A CDS       24981863 chr10:91099132-91099133(+) m6A CDS       24981863 chr10:91099184-91099185(+) m6A CDS       24981863//22575960 chr10:91099197-91099198(+) m6A CDS       24981863//22575960 chr10:91099229-91099230(+) m6A CDS       24981863//27773535//22575960 chr10:91099281-91099282(+) m6A CDS       24209618//24981863//27773535//22575960 chr10:91099358-91099359(+) m6A CDS       24209618//24981863//27773535//22575960 chr10:91099386-91099387(+) m6A CDS       24209618//24981863//27773535//22575960 chr10:91099447-91099448(+) m6A CDS       24981863//27773535//22575960 chr10:91099538-91099539(+) m6A CDS       24981863//27773535 chr10:91099610-91099611(+) m6A CDS       24981863//27773535 chr10:91099734-91099735(+) m6A CDS       24981863 chr10:91099880-91099881(+) m6A CDS       24209618//25456834//24981863//27773535//22575960 chr10:91099886-91099887(+) m6A 3'UTR       24209618//24981863//27773535//22575960 chr10:91099899-91099900(+) m6A 3'UTR       24209618//25456834//24981863//27773535//22575960 chr10:91099952-91099953(+) m6A 3'UTR       24209618//24981863//27773535//22575960 chr10:91100114-91100115(+) m6A 3'UTR       24209618//24981863 chr10:91100235-91100236(+) m6A 3'UTR       24981863 chr10:91100562-91100563(+) m6A 3'UTR       24981863//27773535 chr10:91100571-91100572(+) m6A 3'UTR       24981863//27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	IFIT3	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: IFIT3

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.