Basic Information:

  VIRBase ID:  

VHID00503636

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          HSPA1B:  NM_005346     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	HSPA1B
miRBase Accession/Entrez ID	MIMAT0001581	3304
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	HSP70-1//HSP70-1B//HSP70-2//HSP70.1//HSP70.2//HSP72//HSPA1//HSX70

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	HSPA1B	chr6:31795562(+) A-I      NonSyn:Arg->Gly

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	HSPA1B	chr6:31795598-31795599(+) m6A 5'UTR       24284625//25456834//24981863//22575960//22608085 chr6:31795648-31795649(+) m6A 5'UTR       24284625//25456834//24981863//26404942//27371828//27773536//22575960//22608085 chr6:31795696-31795697(+) Cm 5'UTR       - chr6:31795896-31795897(+) m6A CDS       24981863 chr6:31795911-31795912(+) m6A CDS       24981863 chr6:31795920-31795921(+) m6A CDS       24981863 chr6:31797081-31797082(+) m6A CDS       24981863 chr6:31797423-31797424(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr6:31797431-31797432(+) m1A CDS       26863196 chr6:31797441-31797442(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr6:31797553-31797554(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr6:31797690-31797691(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:31797699-31797700(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:31797707-31797708(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr6:31797958-31797959(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	HSPA1B	Exosome Blood     - Nucleolus K562 cells     - Nucleus Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: HSPA1B

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.