Basic Information:

  VIRBase ID:  

VHID00503610

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          HRAS:  NM_001130442     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	HRAS
miRBase Accession/Entrez ID	MIMAT0001581	3265
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	C-BAS/HAS//C-H-RAS//C-HA-RAS1//CTLO//H-RASIDX//HAMSV//HRAS1//p21ras//RASH1

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	HRAS	chr11:532326-532327(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr11:532346-532347(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr11:532356-532357(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr11:532381-532382(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr11:532404-532405(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr11:532509-532510(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr11:532620-532621(-) m6A 3'UTR//exon//intron       24284625//24209618//24981863//27773535//27371828//27773536//22575960//22608085 chr11:532690-532691(-) m6A 3'UTR//CDS//exon//intron       24209618//22608085 chr11:533304-533305(-) m6A CDS//exon//intron       24209618 chr11:533314-533315(-) m6A CDS//exon//intron       24209618 chr11:533324-533325(-) m6A CDS//exon//intron       24209618 chr11:533460-533461(-) m6A CDS//exon       24209618//27371828//27773536 chr11:533472-533473(-) m6A CDS//exon       24209618//27371828//27773536 chr11:533507-533508(-) m6A CDS//exon       24209618//27371828//27773536 chr11:533555-533556(-) m6A CDS//exon       24209618//27371828//27773536 chr11:533588-533589(-) m6A CDS//exon       24209618//27371828//27773536 chr11:533780-533781(-) m6A CDS//exon       27371828//27773536 chr11:533849-533850(-) m6A CDS//exon       24209618//27773535//22575960 chr11:533894-533895(-) m6A CDS//exon       24209618//27773535//22575960 chr11:534245-534246(-) m6A CDS//exon       24209618//27773535 chr11:534349-534350(-) m6A 5'UTR//exon       24209618//24981863 chr11:534362-534363(-) m6A 5'UTR//exon       24209618//24981863 chr11:535490-535491(-) m6A 5'UTR//intron       24209618 chr11:536874-536875(-) m6A exon       24981863 chr11:536883-536884(-) m6A exon       24981863 chr11:536990-536991(-) m6A exon       24981863 chr11:537035-537036(-) m6A exon       24981863 chr11:537043-537044(-) m6A exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	HRAS	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: HRAS

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.