Basic Information:

  VIRBase ID:  

VHID00503487

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          HIC1:  NM_001098202     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	HIC1
miRBase Accession/Entrez ID	MIMAT0001581	3090
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	hic-1//ZBTB29//ZNF901

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	HIC1	chr17:1958425-1958426(+) m6A 5'UTR       - chr17:1958434-1958435(+) m6A 5'UTR       - chr17:1959622-1959623(+) m6A 5'UTR//CDS//intron       - chr17:1959672-1959673(+) m6A 5'UTR//intron       - chr17:1959991-1959992(+) m6A CDS       - chr17:1960180-1960181(+) m6A CDS       24981863//22608085 chr17:1960222-1960223(+) m6A CDS       24981863//22608085 chr17:1960592-1960593(+) m6A CDS       - chr17:1960654-1960655(+) m6A CDS       - chr17:1960732-1960733(+) m6A CDS       - chr17:1960871-1960872(+) m6A CDS       - chr17:1961398-1961399(+) m6A CDS       - chr17:1961479-1961480(+) m6A CDS       24284625 chr17:1961571-1961572(+) m6A CDS       24284625 chr17:1961923-1961924(+) m6A CDS       24981863//22575960//22608085 chr17:1961955-1961956(+) m6A CDS       24981863//22575960//22608085 chr17:1962102-1962103(+) m6A CDS       24981863 chr17:1962225-1962226(+) m6A 3'UTR       - chr17:1962580-1962581(+) m6A 3'UTR       - chr17:1963896-1963897(+) m1A 3'UTR       26863196

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	HIC1	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: HIC1

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.