Detail Information

Basic Information:


  VIRBase ID:  

VHID00503470

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           HDAC2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p HDAC2
miRBase
Accession/Entrez ID		 MIMAT0001581 3066
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - HD2//KDAC2//RPD3//YAF1

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR HDAC2
chr6:114265700(-) A-I      intronic
chr6:114265806(-) A-I      intronic
chr6:114265703(-) A-I      intronic
chr6:114265885(-) A-I      intronic
chr6:114284316(-) A-I      intronic
chr6:114284339(-) A-I      intronic
chr6:114284385(-) A-I      intronic
chr6:114284515(-) A-I      intronic
chr6:114284512(-) A-I      intronic
chr6:114257976(-) A-I      3'UTR
chr6:114257971(-) A-I      3'UTR
chr6:114258008(-) A-I      3'UTR
chr6:114258007(-) A-I      3'UTR
chr6:114257997(-) A-I      3'UTR
chr6:114257993(-) A-I      3'UTR
chr6:114287552(-) A-I      intronic
chr6:114284537(-) A-I      intronic
chr6:114287633(-) A-I      intronic
chr6:114284016(-) A-I      intronic
chr6:114271767(-) A-I      intronic
chr6:114283880(-) A-I      intronic
chr6:114286598(-) A-I      intronic
chr6:114265930(-) A-I      intronic
chr6:114258032(-) A-I      3'UTR
chr6:114288360(-) A-I      intronic
chr6:114288389(-) A-I      intronic
chr6:114284276(-) A-I      intronic
chr6:114284451(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED HDAC2
chr6:114261880(-) T-A exon 3'UTR    21725310
chr6:114283943(-) A-G intron -    22484847
chr6:114284016(-) A-G intron -    22484847
chr6:114284537(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase HDAC2
chr6:114259443-114259444(-) m6A 3'UTR       27773535
chr6:114259464-114259465(-) m6A 3'UTR       27773535
chr6:114260979-114260980(-) m6A 3'UTR       27773535
chr6:114261964-114261965(-) m6A 3'UTR//exon       27773535
chr6:114262113-114262114(-) m6A 3'UTR//exon       24981863//27773535
chr6:114262147-114262148(-) m6A 3'UTR//exon       24981863//27773535//22608085
chr6:114262239-114262240(-) m6A CDS//exon       24981863//28052920//27773535//27371828//22575960//22608085
chr6:114262884-114262885(-) m6A CDS//exon       24981863//28052920//27773535//27371828//22575960//22608085
chr6:114262901-114262902(-) m6A CDS//exon       24981863//28052920//27773535//27371828//22575960//22608085
chr6:114264517-114264518(-) m6A CDS//exon       24981863//28052920//27773535//27371828//22575960//22608085
chr6:114264525-114264526(-) m6A CDS//exon       24981863//28052920//27773535//27371828//22575960//22608085
chr6:114264532-114264533(-) m6A CDS//exon       24981863//28052920//27773535//27371828//22575960//22608085
chr6:114264657-114264658(-) m6A CDS//exon       24981863//27773535
chr6:114265457-114265458(-) m6A CDS//exon       24981863//27773535
chr6:114265487-114265488(-) m6A CDS//exon       24981863
chr6:114279852-114279853(-) m6A CDS//exon       24981863//26404942
chr6:114292187-114292188(-) m6A 5'UTR//exon//intron       24284625//25456834//24981863//27371828//27773536//22575960

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate HDAC2
Chromatin K562 cells     -
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus HCC cell line (HepG2)     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: HDAC2

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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