Basic Information:

  VIRBase ID:  

VHID00503121

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          GALT:  NM_001258332     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	GALT
miRBase Accession/Entrez ID	MIMAT0001581	2592
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	GALT	chr9:34650153(+) A-I      ncRNA chr9:34650151(+) A-I      ncRNA chr9:34650133(+) A-I      ncRNA

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	GALT	chr9:34646716-34646717(+) m6A 5'UTR//CDS//exon       24284625//24981863 chr9:34646803-34646804(+) m6A exon//intron       24284625//24981863 chr9:34646980-34646981(+) m6A exon//intron       - chr9:34647027-34647028(+) m6A exon//intron       24284625 chr9:34647060-34647061(+) m6A exon//intron       24284625 chr9:34647085-34647086(+) m6A 5'UTR//CDS//exon//intron       - chr9:34647192-34647193(+) m6A 5'UTR//CDS//exon       24284625 chr9:34650269-34650270(+) m6A exon//intron       - chr9:34650376-34650377(+) m6A 3'UTR//CDS//exon       - chr9:34650420-34650421(+) m6A 3'UTR//CDS//exon       - chr9:34650428-34650429(+) m6A 3'UTR//CDS//exon       - chr9:34650609-34650610(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	GALT	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: GALT

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.