Detail Information

Basic Information:


  VIRBase ID:  

VHID00503110

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           GAK:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p GAK
miRBase
Accession/Entrez ID		 MIMAT0001581 2580
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - DNAJ26//DNAJC26

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR GAK
chr4:849631(-) A-I      intronic
chr4:849879(-) A-I      intronic
chr4:849898(-) A-I      intronic
chr4:849921(-) A-I      intronic
chr4:850582(-) A-I      intronic
chr4:850658(-) A-I      intronic
chr4:884943(-) A-I      intronic
chr4:913768(-) A-I      intronic
chr4:913855(-) A-I      intronic
chr4:914329(-) A-I      intronic
chr4:914384(-) A-I      intronic
chr4:914460(-) A-I      intronic
chr4:914470(-) A-I      intronic
chr4:847789(-) A-I      intronic
chr4:916120(-) A-I      intronic
chr4:916135(-) A-I      intronic
chr4:916240(-) A-I      intronic
chr4:916241(-) A-I      intronic
chr4:917456(-) A-I      intronic
chr4:918844(-) A-I      intronic
chr4:922190(-) A-I      intronic
chr4:922257(-) A-I      intronic
chr4:914621(-) A-I      intronic
chr4:847790(-) A-I      intronic
chr4:848589(-) A-I      intronic
chr4:848590(-) A-I      intronic
chr4:848640(-) A-I      intronic
chr4:849599(-) A-I      intronic
chr4:849621(-) A-I      intronic
chr4:847697(-) A-I      intronic
chr4:849667(-) A-I      intronic
chr4:849705(-) A-I      intronic
chr4:916217(-) A-I      intronic
chr4:848711(-) A-I      intronic
chr4:850542(-) A-I      intronic
chr4:845124(-) A-I      intronic
chr4:848769(-) A-I      intronic
chr4:922118(-) A-I      intronic
chr4:850636(-) A-I      intronic
chr4:845053(-) A-I      intronic
chr4:849737(-) A-I      intronic
chr4:846525(-) A-I      intronic
chr4:902566(-) A-I      intronic
chr4:913704(-) A-I      intronic
chr4:902398(-) A-I      intronic
chr4:849494(-) A-I      intronic
chr4:891571(-) A-I      intronic
chr4:847762(-) A-I      intronic
chr4:849680(-) A-I      intronic
chr4:846897(-) A-I      intronic
chr4:847701(-) A-I      intronic
chr4:849539(-) A-I      intronic
chr4:913915(-) A-I      intronic
chr4:850588(-) A-I      intronic
chr4:846339(-) A-I      intronic
chr4:902246(-) A-I      intronic
chr4:914969(-) A-I      intronic
chr4:847675(-) A-I      intronic
chr4:849852(-) A-I      intronic
chr4:849491(-) A-I      intronic
chr4:848830(-) A-I      intronic
chr4:849860(-) A-I      intronic
chr4:910283(-) A-I      intronic
chr4:913865(-) A-I      intronic
chr4:879818(-) A-I      intronic
chr4:902779(-) A-I      intronic
chr4:848733(-) A-I      intronic
chr4:902329(-) A-I      intronic
chr4:850642(-) A-I      intronic
chr4:849840(-) A-I      intronic
chr4:849797(-) A-I      intronic
chr4:879660(-) A-I      intronic
chr4:848568(-) A-I      intronic
chr4:914987(-) A-I      intronic
chr4:915154(-) A-I      intronic
chr4:915155(-) A-I      intronic
chr4:849551(-) A-I      intronic
chr4:922127(-) A-I      intronic
chr4:847765(-) A-I      intronic
chr4:913984(-) A-I      intronic
chr4:850563(-) A-I      intronic
chr4:847768(-) A-I      intronic
chr4:844996(-) A-I      intronic
chr4:913948(-) A-I      intronic
chr4:902259(-) A-I      intronic
chr4:849560(-) A-I      intronic
chr4:902353(-) A-I      intronic
chr4:915090(-) A-I      intronic
chr4:902739(-) A-I      intronic
chr4:850571(-) A-I      intronic
chr4:848721(-) A-I      intronic
chr4:913974(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED GAK
chr4:850563(-) A-I intron -    21960545   //22327324
chr4:850642(-) A-I intron -    21960545
chr4:845139(-) G-A intron -    22484847
chr4:846366(-) A-G intron -    22484847
chr4:849491(-) A-G intron -    22484847
chr4:849494(-) A-G intron -    22484847
chr4:849551(-) A-G intron -    22484847
chr4:849560(-) A-G intron -    22484847
chr4:849680(-) A-G intron -    22484847
chr4:850642(-) A-G intron -    22484847
chr4:857916(-) C-T intron -    22484847
chr4:889847(-) G-A intron -    22484847
chr4:896403(-) G-T intron -    22484847
chr4:896404(-) G-T intron -    22484847
chr4:902329(-) A-G intron -    22484847
chr4:902353(-) A-G intron -    22484847
chr4:902490(-) A-G intron -    22484847
chr4:902739(-) A-G intron -    22484847
chr4:902756(-) A-G intron -    22484847
chr4:902779(-) A-G intron -    22484847
chr4:902801(-) A-G intron -    22484847
chr4:902930(-) A-G intron -    22484847
chr4:913907(-) A-G intron -    22484847
chr4:913915(-) A-G intron -    22484847
chr4:915168(-) A-G intron -    22484847
chr4:916217(-) A-G intron -    22484847
chr4:922127(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase GAK
chr4:843247-843248(-) m6A 3'UTR//exon       24284625
chr4:843383-843384(-) m6A 3'UTR//exon       24284625//27773536
chr4:843404-843405(-) m6A 3'UTR//exon       24284625//27773536
chr4:843485-843486(-) m6A 3'UTR//CDS//exon       24284625
chr4:843824-843825(-) m6A 3'UTR//CDS//exon       24284625//25456834//27773535//27371828//27773536//22608085
chr4:843848-843849(-) m6A 3'UTR//CDS//exon       24284625//25456834//27773535//27371828//27773536//22608085
chr4:844187-844188(-) m6A exon//intron       -
chr4:844274-844275(-) m6A exon//intron       -
chr4:844530-844531(-) m6A exon//intron       27371828
chr4:844566-844567(-) m6A exon//intron       27371828
chr4:844572-844573(-) m6A exon//intron       27371828
chr4:844739-844740(-) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//27371828//27773536
chr4:844745-844746(-) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//27371828//27773536
chr4:844757-844758(-) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//27371828//27773536
chr4:844782-844783(-) m6A CDS//exon       24284625//24981863//27773535//27371828//27773536
chr4:844899-844900(-) m6A exon//intron       24284625//27773535//27773536
chr4:844911-844912(-) m6A exon//intron       24284625//27773535//27773536
chr4:845590-845591(-) m6A CDS//exon       27773536
chr4:845600-845601(-) Y CDS//exon       26075521
chr4:845684-845685(-) m6A CDS//exon       27773536
chr4:845799-845800(-) m6A exon//intron       27773536
chr4:845819-845820(-) m6A exon//intron       27773536
chr4:846933-846934(-) m6A exon//intron       24284625
chr4:847089-847090(-) m6A exon//intron       24284625
chr4:847147-847148(-) m6A exon//intron       24284625
chr4:847170-847171(-) m6A exon//intron       24284625
chr4:847196-847197(-) m6A exon//intron       24284625//27371828
chr4:847224-847225(-) m6A exon//intron       24284625//27371828
chr4:847387-847388(-) m6A exon//intron       24284625//27371828//27773536
chr4:847463-847464(-) m6A exon//intron       24284625//27371828
chr4:847520-847521(-) m6A exon//intron       24284625//27371828
chr4:847565-847566(-) m6A exon//intron       24284625//27371828
chr4:847575-847576(-) m6A exon//intron       24284625//27371828
chr4:853434-853435(-) m6A CDS//exon//intron       27773536
chr4:853440-853441(-) m6A CDS//exon//intron       27773536
chr4:853453-853454(-) m6A CDS//exon//intron       27773536
chr4:858948-858949(-) m6A CDS//exon       24284625//27773536
chr4:858954-858955(-) m6A CDS//exon       24284625//27773536
chr4:858980-858981(-) m6A CDS//exon       24284625//27371828//27773536
chr4:860231-860232(-) m6A CDS//exon       24284625//24981863//28052920//27773535//27371828//27773536
chr4:860817-860818(-) m6A CDS//exon//intron       24284625//27371828//27773536
chr4:861016-861017(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22608085
chr4:861036-861037(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22608085
chr4:861089-861090(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr4:861150-861151(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr4:861202-861203(-) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr4:862334-862335(-) m6A CDS//exon//intron       24284625//24209618//25456834//27773535//27371828//27773536//22575960//22608085
chr4:862391-862392(-) m6A CDS//exon//intron       27773535//27371828//27773536//22608085
chr4:862399-862400(-) m6A CDS//exon//intron       27773535//27371828//27773536//22608085
chr4:864515-864516(-) m6A CDS//exon//intron       27371828
chr4:864554-864555(-) m6A CDS//exon//intron       -
chr4:864575-864576(-) m6A CDS//exon//intron       -
chr4:864608-864609(-) m6A CDS//exon//intron       -
chr4:864635-864636(-) m6A CDS//exon//intron       27773535
chr4:870992-870993(-) m6A CDS//intron       -
chr4:876485-876486(-) Tm CDS//intron       -
chr4:880309-880310(-) m6A exon//intron       27773535
chr4:880410-880411(-) m6A exon//intron       24981863
chr4:880415-880416(-) m6A exon//intron       24981863
chr4:880463-880464(-) m6A exon//intron       25456834//24981863
chr4:880480-880481(-) m6A exon//intron       25456834//24981863
chr4:887186-887187(-) m6A CDS//exon//intron       27773536
chr4:887258-887259(-) m6A 3'UTR//CDS//exon//intron       24284625
chr4:888432-888433(-) m6A exon//intron       27773535//27371828
chr4:890290-890291(-) m6A 3'UTR//CDS//intron       27773535
chr4:890306-890307(-) m6A 3'UTR//CDS//intron       27773535
chr4:907480-907481(-) m6A exon//intron       -
chr4:925873-925874(-) m6A CDS//exon       24284625//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate GAK
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Colon cancer cells     24393600
Nucleus HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: GAK

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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