Basic Information:

  VIRBase ID:  

VHID00502859

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          ESR1:  NM_001122740     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	ESR1
miRBase Accession/Entrez ID	MIMAT0001581	2099
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	ER//Era//ESR//ESRA//ESTRR//NR3A1

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ESR1	chr6:152174084(+) A-I      intronic chr6:152174059(+) A-I      intronic chr6:152172763(+) A-I      intronic chr6:152172743(+) A-I      intronic chr6:152174097(+) A-I      intronic chr6:152174123(+) A-I      intronic chr6:152306903(+) A-I      intronic chr6:152174147(+) A-I      intronic chr6:152174146(+) A-I      intronic chr6:152174145(+) A-I      intronic chr6:152158469(+) A-I      intronic chr6:152174160(+) A-I      intronic chr6:152113826(+) A-I      intronic chr6:152077572(+) A-I      intronic chr6:152306933(+) A-I      intronic chr6:152306941(+) A-I      intronic chr6:152306992(+) A-I      intronic chr6:152158457(+) A-I      intronic chr6:152174156(+) A-I      intronic chr6:152174154(+) A-I      intronic chr6:152174164(+) A-I      intronic chr6:152174200(+) A-I      intronic chr6:152174227(+) A-I      intronic chr6:152341689(+) A-I      intronic chr6:152174248(+) A-I      intronic chr6:152410911(+) A-I      intronic chr6:152208039(+) A-I      intronic chr6:152303671(+) A-I      intronic chr6:152174149(+) A-I      intronic chr6:152303675(+) A-I      intronic chr6:152174153(+) A-I      intronic chr6:152077563(+) A-I      intronic chr6:152074688(+) A-I      intronic chr6:152306496(+) A-I      intronic chr6:152077557(+) A-I      intronic chr6:152306877(+) A-I      intronic chr6:152410903(+) A-I      intronic chr6:152174148(+) A-I      intronic chr6:152174052(+) A-I      intronic chr6:152052370(+) A-I      intronic chr6:152174196(+) A-I      intronic chr6:152306564(+) A-I      intronic chr6:152174233(+) A-I      intronic chr6:152430560(+) A-I      intronic chr6:152174054(+) A-I      intronic chr6:152076170(+) A-I      intronic chr6:152174055(+) A-I      intronic chr6:152306932(+) A-I      intronic chr6:152172732(+) A-I      intronic chr6:152174228(+) A-I      intronic chr6:152074673(+) A-I      intronic chr6:152176263(+) A-I      intronic chr6:152199140(+) A-I      intronic chr6:152307026(+) A-I      intronic chr6:152076105(+) A-I      intronic chr6:152172682(+) A-I      intronic chr6:152096760(+) A-I      intronic chr6:152172694(+) A-I      intronic chr6:152174213(+) A-I      intronic chr6:152306977(+) A-I      intronic chr6:152306549(+) A-I      intronic chr6:152015745(+) A-I      intronic chr6:152341847(+) A-I      intronic chr6:152076308(+) A-I      intronic chr6:152076180(+) A-I      intronic chr6:152174216(+) A-I      intronic chr6:152306558(+) A-I      intronic chr6:152076289(+) A-I      intronic chr6:152308596(+) A-I      intronic chr6:152414226(+) A-I      intronic chr6:152079731(+) A-I      intronic chr6:152306563(+) A-I      intronic chr6:152022681(+) A-I      intronic chr6:152307025(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ESR1	chr6:152144248(+) A-I intron -    21960545 chr6:152174017(+) A-I intron -    21960545 chr6:152174018(+) A-I intron -    21960545 chr6:152174186(+) A-I intron -    21960545 chr6:152174200(+) A-I intron -    21960545 chr6:152176263(+) A-I intron -    21960545 chr6:152186118(+) A-I intron -    21960545 chr6:152186123(+) A-I intron -    21960545 chr6:152187578(+) A-I intron -    21960545 chr6:152187586(+) A-I intron -    21960545 chr6:152187696(+) A-I intron -    21960545 chr6:152306385(+) A-I intron -    21960545 chr6:152306386(+) A-I intron -    21960545

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ESR1	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: ESR1

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.