Basic Information:

  VIRBase ID:  

VHID00502795

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7903

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          MARK2:  NM_001163297     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	MARK2
miRBase Accession/Entrez ID	MIMAT0001581	2011
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	EMK-1//EMK1//PAR-1//Par-1b//Par1b

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MARK2	chr11:63628207(+) A-I      intronic chr11:63617134(+) A-I      intronic chr11:63617145(+) A-I      intronic chr11:63628164(+) A-I      intronic chr11:63628171(+) A-I      intronic chr11:63628179(+) A-I      intronic chr11:63628285(+) A-I      intronic chr11:63628255(+) A-I      intronic chr11:63627278(+) A-I      intronic chr11:63627243(+) A-I      intronic chr11:63627230(+) A-I      intronic chr11:63627199(+) A-I      intronic chr11:63627127(+) A-I      intronic chr11:63626099(+) A-I      intronic chr11:63625992(+) A-I      intronic chr11:63625943(+) A-I      intronic chr11:63625868(+) A-I      intronic chr11:63624670(+) A-I      intronic chr11:63627293(+) A-I      intronic chr11:63622849(+) A-I      intronic chr11:63622833(+) A-I      intronic chr11:63622832(+) A-I      intronic chr11:63622713(+) A-I      intronic chr11:63622123(+) A-I      intronic chr11:63622097(+) A-I      intronic chr11:63621941(+) A-I      intronic chr11:63621924(+) A-I      intronic chr11:63621722(+) A-I      intronic chr11:63621510(+) A-I      intronic chr11:63621462(+) A-I      intronic chr11:63621394(+) A-I      intronic chr11:63620721(+) A-I      intronic chr11:63620711(+) A-I      intronic chr11:63620706(+) A-I      intronic chr11:63618370(+) A-I      intronic chr11:63617180(+) A-I      intronic chr11:63611944(+) A-I      intronic chr11:63617098(+) A-I      intronic chr11:63617096(+) A-I      intronic chr11:63617075(+) A-I      intronic chr11:63617073(+) A-I      intronic chr11:63617047(+) A-I      intronic chr11:63616969(+) A-I      intronic chr11:63615921(+) A-I      intronic chr11:63615911(+) A-I      intronic chr11:63614550(+) A-I      intronic chr11:63614491(+) A-I      intronic chr11:63614488(+) A-I      intronic chr11:63613274(+) A-I      intronic chr11:63613234(+) A-I      intronic chr11:63609872(+) A-I      intronic chr11:63614462(+) A-I      intronic chr11:63609869(+) A-I      intronic chr11:63609788(+) A-I      intronic chr11:63651169(+) A-I      intronic chr11:63632400(+) A-I      intronic chr11:63644709(+) A-I      intronic chr11:63621625(+) A-I      intronic chr11:63646606(+) A-I      intronic chr11:63637793(+) A-I      intronic chr11:63653490(+) A-I      intronic chr11:63626049(+) A-I      intronic chr11:63611865(+) A-I      intronic chr11:63632140(+) A-I      intronic chr11:63627979(+) A-I      intronic chr11:63620615(+) A-I      intronic chr11:63616528(+) A-I      intronic chr11:63625408(+) A-I      intronic chr11:63628658(+) A-I      intronic chr11:63621789(+) A-I      intronic chr11:63614515(+) A-I      intronic chr11:63613469(+) A-I      intronic chr11:63622845(+) A-I      intronic chr11:63652888(+) A-I      intronic chr11:63629659(+) A-I      intronic chr11:63617069(+) A-I      intronic chr11:63624815(+) A-I      intronic chr11:63653738(+) A-I      intronic chr11:63646615(+) A-I      intronic chr11:63633703(+) A-I      intronic chr11:63616525(+) A-I      intronic chr11:63621811(+) A-I      intronic chr11:63625955(+) A-I      intronic chr11:63642735(+) A-I      intronic chr11:63644766(+) A-I      intronic chr11:63652432(+) A-I      intronic chr11:63615996(+) A-I      intronic chr11:63621607(+) A-I      intronic chr11:63622753(+) A-I      intronic chr11:63626814(+) A-I      intronic chr11:63629577(+) A-I      intronic chr11:63609818(+) A-I      intronic chr11:63622959(+) A-I      intronic chr11:63617035(+) A-I      intronic chr11:63653977(+) A-I      intronic chr11:63653961(+) A-I      intronic chr11:63653928(+) A-I      intronic chr11:63653818(+) A-I      intronic chr11:63653783(+) A-I      intronic chr11:63653781(+) A-I      intronic chr11:63646598(+) A-I      intronic chr11:63625334(+) A-I      intronic chr11:63653638(+) A-I      intronic chr11:63653629(+) A-I      intronic chr11:63652764(+) A-I      intronic chr11:63652625(+) A-I      intronic chr11:63652519(+) A-I      intronic chr11:63652517(+) A-I      intronic chr11:63651342(+) A-I      intronic chr11:63651287(+) A-I      intronic chr11:63651183(+) A-I      intronic chr11:63651156(+) A-I      intronic chr11:63648683(+) A-I      intronic chr11:63648504(+) A-I      intronic chr11:63646691(+) A-I      intronic chr11:63646599(+) A-I      intronic chr11:63633659(+) A-I      intronic chr11:63646552(+) A-I      intronic chr11:63646527(+) A-I      intronic chr11:63645971(+) A-I      intronic chr11:63645091(+) A-I      intronic chr11:63645086(+) A-I      intronic chr11:63645050(+) A-I      intronic chr11:63629275(+) A-I      intronic chr11:63635666(+) A-I      intronic chr11:63633756(+) A-I      intronic chr11:63620791(+) A-I      intronic chr11:63633752(+) A-I      intronic chr11:63633713(+) A-I      intronic chr11:63632221(+) A-I      intronic chr11:63632049(+) A-I      intronic chr11:63629496(+) A-I      intronic chr11:63629564(+) A-I      intronic chr11:63629551(+) A-I      intronic chr11:63629525(+) A-I      intronic chr11:63629500(+) A-I      intronic chr11:63628745(+) A-I      intronic chr11:63626922(+) A-I      intronic chr11:63628636(+) A-I      intronic chr11:63621445(+) A-I      intronic chr11:63611177(+) A-I      intronic chr11:63622854(+) A-I      intronic chr11:63611196(+) A-I      intronic chr11:63653052(+) A-I      intronic chr11:63628183(+) A-I      intronic chr11:63645121(+) A-I      intronic chr11:63622029(+) A-I      intronic chr11:63618814(+) A-I      intronic chr11:63627364(+) A-I      intronic chr11:63648617(+) A-I      intronic chr11:63647169(+) A-I      intronic chr11:63615937(+) A-I      intronic chr11:63621813(+) A-I      intronic chr11:63632501(+) A-I      intronic chr11:63609789(+) A-I      intronic chr11:63617046(+) A-I      intronic chr11:63652846(+) A-I      intronic chr11:63621909(+) A-I      intronic chr11:63629475(+) A-I      intronic chr11:63620797(+) A-I      intronic chr11:63628176(+) A-I      intronic chr11:63634599(+) A-I      intronic chr11:63625432(+) A-I      intronic chr11:63618824(+) A-I      intronic chr11:63644763(+) A-I      intronic chr11:63648622(+) A-I      intronic chr11:63646626(+) A-I      intronic chr11:63632131(+) A-I      intronic chr11:63628665(+) A-I      intronic chr11:63622875(+) A-I      intronic chr11:63614510(+) A-I      intronic chr11:63652742(+) A-I      intronic chr11:63622196(+) A-I      intronic chr11:63632503(+) A-I      intronic chr11:63613384(+) A-I      intronic chr11:63629444(+) A-I      intronic chr11:63653997(+) A-I      intronic chr11:63645122(+) A-I      intronic chr11:63628069(+) A-I      intronic chr11:63633662(+) A-I      intronic chr11:63628223(+) A-I      intronic chr11:63615932(+) A-I      intronic chr11:63618326(+) A-I      intronic chr11:63627056(+) A-I      intronic chr11:63624778(+) A-I      intronic chr11:63625326(+) A-I      intronic chr11:63628720(+) A-I      intronic chr11:63613460(+) A-I      intronic chr11:63628797(+) A-I      intronic chr11:63628704(+) A-I      intronic chr11:63627065(+) A-I      intronic chr11:63652510(+) A-I      intronic chr11:63633599(+) A-I      intronic chr11:63628010(+) A-I      intronic chr11:63617026(+) A-I      intronic chr11:63622092(+) A-I      intronic chr11:63629457(+) A-I      intronic chr11:63629617(+) A-I      intronic chr11:63628245(+) A-I      intronic chr11:63617059(+) A-I      intronic chr11:63646700(+) A-I      intronic chr11:63631289(+) A-I      intronic chr11:63621425(+) A-I      intronic chr11:63626910(+) A-I      intronic chr11:63628173(+) A-I      intronic chr11:63617185(+) A-I      intronic chr11:63622938(+) A-I      intronic chr11:63616307(+) A-I      intronic chr11:63622186(+) A-I      intronic chr11:63614028(+) A-I      intronic chr11:63617104(+) A-I      intronic chr11:63611726(+) A-I      intronic chr11:63631076(+) A-I      intronic chr11:63646102(+) A-I      intronic chr11:63627363(+) A-I      intronic chr11:63644928(+) A-I      intronic chr11:63611762(+) A-I      intronic chr11:63632227(+) A-I      intronic chr11:63621579(+) A-I      intronic chr11:63653643(+) A-I      intronic chr11:63629294(+) A-I      intronic chr11:63611852(+) A-I      intronic chr11:63649314(+) A-I      intronic chr11:63620710(+) A-I      intronic chr11:63609878(+) A-I      intronic chr11:63625919(+) A-I      intronic chr11:63634628(+) A-I      intronic chr11:63622790(+) A-I      intronic chr11:63621395(+) A-I      intronic chr11:63628788(+) A-I      intronic chr11:63622035(+) A-I      intronic chr11:63633774(+) A-I      intronic chr11:63624423(+) A-I      intronic chr11:63653481(+) A-I      intronic chr11:63627173(+) A-I      intronic chr11:63625768(+) A-I      intronic chr11:63646048(+) A-I      intronic chr11:63613734(+) A-I      intronic chr11:63635682(+) A-I      intronic chr11:63633749(+) A-I      intronic chr11:63613275(+) A-I      intronic chr11:63629580(+) A-I      intronic chr11:63621376(+) A-I      intronic chr11:63652753(+) A-I      intronic chr11:63652528(+) A-I      intronic chr11:63611277(+) A-I      intronic chr11:63628864(+) A-I      intronic chr11:63653728(+) A-I      intronic chr11:63622187(+) A-I      intronic chr11:63628661(+) A-I      intronic chr11:63621801(+) A-I      intronic chr11:63611714(+) A-I      intronic chr11:63615994(+) A-I      intronic chr11:63631506(+) A-I      intronic chr11:63621703(+) A-I      intronic chr11:63649331(+) A-I      intronic chr11:63627754(+) A-I      intronic chr11:63621484(+) A-I      intronic chr11:63651174(+) A-I      intronic chr11:63622846(+) A-I      intronic chr11:63613967(+) A-I      intronic chr11:63653131(+) A-I      intronic chr11:63625576(+) A-I      intronic chr11:63653793(+) A-I      intronic chr11:63611307(+) A-I      intronic chr11:63614084(+) A-I      intronic chr11:63625965(+) A-I      intronic chr11:63624784(+) A-I      intronic chr11:63652943(+) A-I      intronic chr11:63616508(+) A-I      intronic chr11:63652890(+) A-I      intronic chr11:63652523(+) A-I      intronic chr11:63627367(+) A-I      intronic chr11:63622073(+) A-I      intronic chr11:63625756(+) A-I      intronic chr11:63616500(+) A-I      intronic chr11:63628209(+) A-I      intronic chr11:63653660(+) A-I      intronic chr11:63625926(+) A-I      intronic chr11:63629571(+) A-I      intronic chr11:63617072(+) A-I      intronic chr11:63653293(+) A-I      intronic chr11:63617078(+) A-I      intronic chr11:63633704(+) A-I      intronic chr11:63609828(+) A-I      intronic chr11:63645067(+) A-I      intronic chr11:63613807(+) A-I      intronic chr11:63628730(+) A-I      intronic chr11:63652936(+) A-I      intronic chr11:63609952(+) A-I      intronic chr11:63613733(+) A-I      intronic chr11:63611769(+) A-I      intronic chr11:63611280(+) A-I      intronic chr11:63617102(+) A-I      intronic chr11:63629594(+) A-I      intronic chr11:63632138(+) A-I      intronic chr11:63635743(+) A-I      intronic chr11:63624675(+) A-I      intronic chr11:63613727(+) A-I      intronic chr11:63644511(+) A-I      intronic chr11:63616597(+) A-I      intronic chr11:63622882(+) A-I      intronic chr11:63653870(+) A-I      intronic chr11:63611195(+) A-I      intronic chr11:63624768(+) A-I      intronic chr11:63620616(+) A-I      intronic chr11:63654118(+) A-I      intronic chr11:63621619(+) A-I      intronic chr11:63617208(+) A-I      intronic chr11:63616996(+) A-I      intronic chr11:63651083(+) A-I      intronic chr11:63613295(+) A-I      intronic chr11:63622213(+) A-I      intronic chr11:63609753(+) A-I      intronic chr11:63631825(+) A-I      intronic chr11:63654057(+) A-I      intronic chr11:63654070(+) A-I      intronic chr11:63617170(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MARK2	chr11:63617102(+) A-G intron -    22484847 chr11:63646598(+) A-G intron -    22484847 chr11:63660402(+) C-T intron -    22484847 chr11:63660412(+) C-A intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MARK2	chr11:63606993-63606994(+) m6A 5'UTR//CDS       24284625//22575960 chr11:63607021-63607022(+) m6A 5'UTR//CDS       24284625//22575960 chr11:63617461-63617462(+) m6A 5'UTR//intron       24284625 chr11:63668298-63668299(+) m6A CDS       24981863 chr11:63668336-63668337(+) m6A CDS       24981863 chr11:63668347-63668348(+) m6A CDS       24981863 chr11:63668470-63668471(+) m6A CDS       24284625//24981863 chr11:63669695-63669696(+) m6A CDS       24284625 chr11:63670116-63670117(+) m6A CDS       24284625//24981863 chr11:63670156-63670157(+) m6A CDS       24284625//24981863 chr11:63670233-63670234(+) m6A CDS//exon       24284625//24981863 chr11:63670626-63670627(+) m6A CDS//exon//intron       24284625 chr11:63670637-63670638(+) m6A exon//intron       24284625 chr11:63675743-63675744(+) m6A CDS//intron       24284625 chr11:63675757-63675758(+) m6A CDS//intron       24284625 chr11:63676442-63676443(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr11:63676503-63676504(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:63676572-63676573(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:63676603-63676604(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:63676671-63676672(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr11:63676788-63676789(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960 chr11:63677103-63677104(+) m6A 3'UTR       24209618//25456834//24981863 chr11:63677112-63677113(+) m6A 3'UTR       24209618//25456834//24981863 chr11:63677155-63677156(+) m6A 3'UTR       24209618//25456834//24981863 chr11:63677250-63677251(+) m6A 3'UTR       24209618//25456834//24981863 chr11:63677898-63677899(+) m6A 3'UTR       24209618 chr11:63678273-63678274(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	MARK2	Chromatin K562 cells     - Cytosol K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: MARK2

Evidence Support:

Strong-Evidence	RISC-IP
Prediction-Evidence	miRanda//RNAHybrid
Support Database	ViRBase//VmiReg

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.