Basic Information:

  VIRBase ID:  

VHID00502726

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          S1PR1:  NM_001400     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	S1PR1
miRBase Accession/Entrez ID	MIMAT0001581	1901
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	CD363//CHEDG1//D1S3362//ECGF1//EDG-1//EDG1//S1P1

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	S1PR1	chr1:101702480-101702481(+) m6A 5'UTR       - chr1:101702499-101702500(+) m6A 5'UTR//exon       - chr1:101702535-101702536(+) m6A 5'UTR//exon       - chr1:101704658-101704659(+) m6A CDS//exon       22608085 chr1:101704667-101704668(+) m6A CDS//exon       24981863//22608085 chr1:101704677-101704678(+) m6A CDS//exon       24981863//22608085 chr1:101704727-101704728(+) m6A CDS//exon       24981863//22608085 chr1:101704756-101704757(+) m6A CDS//exon       24981863//22608085 chr1:101704811-101704812(+) m6A CDS//exon       24981863//22608085 chr1:101704989-101704990(+) m6A CDS//exon       24981863//22608085 chr1:101705087-101705088(+) m6A CDS       24981863//22608085 chr1:101705227-101705228(+) m6A CDS       24981863 chr1:101705258-101705259(+) m6A CDS       24981863 chr1:101705308-101705309(+) m6A CDS       - chr1:101705395-101705396(+) m6A CDS       - chr1:101705543-101705544(+) m6A CDS       25456834//24981863//22575960//22608085 chr1:101705606-101705607(+) m6A CDS       25456834//24981863//22575960//22608085 chr1:101705639-101705640(+) m6A CDS       25456834//24981863//22575960//22608085 chr1:101705650-101705651(+) m6A CDS       25456834//24981863//22608085 chr1:101705690-101705691(+) m6A 3'UTR       25456834//24981863//22608085 chr1:101705828-101705829(+) m6A 3'UTR       25456834//24981863//22608085 chr1:101705875-101705876(+) m6A 3'UTR       25456834//24981863//22608085 chr1:101706012-101706013(+) m6A 3'UTR       24981863 chr1:101706085-101706086(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	S1PR1	Cytosol HeLa-S3 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: S1PR1

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.