Basic Information:

  VIRBase ID:  

VHID00502712

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7903

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          E2F2:  NM_004091     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	E2F2
miRBase Accession/Entrez ID	MIMAT0001581	1870
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	E2F-2

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	E2F2	chr1:23839443(-) A-I      intronic chr1:23839529(-) A-I      intronic chr1:23840492(-) A-I      intronic chr1:23849928(-) A-I      intronic chr1:23842412(-) A-I      intronic chr1:23838507(-) A-I      intronic chr1:23840533(-) A-I      intronic chr1:23840530(-) A-I      intronic chr1:23840424(-) A-I      intronic chr1:23839437(-) A-I      intronic chr1:23838630(-) A-I      intronic chr1:23837044(-) A-I      intronic chr1:23836999(-) A-I      intronic chr1:23836996(-) A-I      intronic chr1:23836994(-) A-I      intronic chr1:23836915(-) A-I      intronic chr1:23841207(-) A-I      intronic chr1:23841221(-) A-I      intronic chr1:23842413(-) A-I      intronic chr1:23836914(-) A-I      intronic chr1:23837927(-) A-I      intronic chr1:23842393(-) A-I      intronic chr1:23839401(-) A-I      intronic chr1:23836955(-) A-I      intronic chr1:23841270(-) A-I      intronic chr1:23839365(-) A-I      intronic chr1:23840500(-) A-I      intronic chr1:23841128(-) A-I      intronic chr1:23842272(-) A-I      intronic chr1:23837851(-) A-I      intronic chr1:23841285(-) A-I      intronic chr1:23839442(-) A-I      intronic chr1:23837096(-) A-I      intronic chr1:23839445(-) A-I      intronic chr1:23841103(-) A-I      intronic chr1:23839402(-) A-I      intronic chr1:23837803(-) A-I      intronic chr1:23841137(-) A-I      intronic chr1:23850466(-) A-I      intronic chr1:23841266(-) A-I      intronic chr1:23839551(-) A-I      intronic chr1:23838524(-) A-I      intronic chr1:23842469(-) A-I      intronic chr1:23840497(-) A-I      intronic chr1:23839390(-) A-I      intronic chr1:23849924(-) A-I      intronic chr1:23839475(-) A-I      intronic chr1:23840539(-) A-I      intronic chr1:23842410(-) A-I      intronic chr1:23838546(-) A-I      intronic chr1:23842331(-) A-I      intronic chr1:23838473(-) A-I      intronic chr1:23839542(-) A-I      intronic chr1:23842352(-) A-I      intronic chr1:23837088(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	E2F2	chr1:23839445(-) A-I intron -    22327324 chr1:23837096(-) A-G intron -    22484847 chr1:23838473(-) A-G intron -    22484847 chr1:23839442(-) A-G intron -    22484847 chr1:23839445(-) A-G intron -    22484847 chr1:23840539(-) A-G intron -    22484847 chr1:23841103(-) A-G intron -    22484847 chr1:23841128(-) A-G intron -    22484847 chr1:23841137(-) A-G intron -    22484847 chr1:23841270(-) A-G intron -    22484847 chr1:23841285(-) A-G intron -    22484847 chr1:23842393(-) A-G intron -    22484847 chr1:23849924(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	E2F2	chr1:23835817-23835818(-) m6A 3'UTR       24284625 chr1:23836282-23836283(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27371828//22575960//22608085 chr1:23836289-23836290(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27371828//22575960//22608085 chr1:23836320-23836321(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27371828//22575960//22608085 chr1:23836387-23836388(-) m6A CDS       24284625//24209618//25456834//24981863//27371828//22575960//22608085 chr1:23836462-23836463(-) m6A CDS       24284625//24209618//25456834//24981863//27371828//27773536//22575960 chr1:23836525-23836526(-) m6A CDS       24284625//24209618//25456834//27371828//27773536//22575960 chr1:23836532-23836533(-) m6A CDS       24284625//24209618//25456834//27371828//27773536//22575960 chr1:23842939-23842940(-) m6A CDS//exon       24284625//24981863//27371828//27773536 chr1:23845512-23845513(-) m6A CDS//exon       24284625//27371828 chr1:23845531-23845532(-) m6A CDS//exon       24284625//27371828 chr1:23845566-23845567(-) m6A CDS//exon       - chr1:23845652-23845653(-) m6A exon//intron       - chr1:23847467-23847468(-) m6A CDS       27371828 chr1:23847485-23847486(-) m6A CDS       27371828 chr1:23847532-23847533(-) m6A CDS       27371828 chr1:23847542-23847543(-) m6A CDS       27371828 chr1:23848343-23848344(-) m6A CDS       24284625 chr1:23848439-23848440(-) m6A CDS       24284625 chr1:23848445-23848446(-) m6A CDS       24284625 chr1:23848524-23848525(-) m6A CDS       24284625 chr1:23857342-23857343(-) m6A 5'UTR       27773536 chr1:23857528-23857529(-) m6A 5'UTR       27371828//27773536 chr1:23857591-23857592(-) m6A 5'UTR       27371828//27773536 chr1:23857613-23857614(-) m6A 5'UTR       25456834//24981863//27371828//27773536 chr1:23857670-23857671(-) m6A 5'UTR       24284625//25456834//24981863//27371828//27773536 chr1:23857708-23857709(-) m6A 5'UTR       24284625//25456834//24981863//27371828//27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	E2F2	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)|HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: E2F2

Evidence Support:

Strong-Evidence	RISC-IP
Prediction-Evidence	miRanda//PITA
Support Database	ViRBase//VmiReg

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.