Detail Information

Basic Information:


  VIRBase ID:  

VHID00502685

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           TSC22D3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p TSC22D3
miRBase
Accession/Entrez ID		 MIMAT0001581 1831
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - DIP//DSIPI//GILZ//TSC-22R

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TSC22D3
chrX:107006255(-) A-I      intronic
chrX:107006251(-) A-I      intronic
chrX:107001136(-) A-I      intronic
chrX:107006195(-) A-I      intronic
chrX:107001209(-) A-I      intronic
chrX:107002207(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TSC22D3
chrX:106957269-106957270(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chrX:106957375-106957376(-) m6A 3'UTR       24284625//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chrX:106957577-106957578(-) m6A 3'UTR       24284625//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chrX:106957608-106957609(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chrX:106957650-106957651(-) m6A 3'UTR       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085
chrX:106957713-106957714(-) m6A 3'UTR       24284625//24981863//28052920//27773535//22575960//22608085
chrX:106957858-106957859(-) m6A CDS       24284625//24981863//27773535//27371828//27773536
chrX:106957872-106957873(-) m6A CDS       24284625//24981863//27773535//27371828//27773536
chrX:106957893-106957894(-) m6A CDS       24284625//24981863//28052920//27773535//27371828//27773536
chrX:106957918-106957919(-) Cm CDS       -
chrX:106959027-106959028(-) m6A CDS//intron       24981863//28052920//27773535//27371828//27773536
chrX:106959137-106959138(-) m6A 5'UTR//CDS       24981863
chrX:106959150-106959151(-) m6A 5'UTR//CDS       24981863
chrX:106959220-106959221(-) m6A 5'UTR//intron       24981863
chrX:106959255-106959256(-) m6A 5'UTR//intron       25456834//24981863//27773536
chrX:106959312-106959313(-) m6A 5'UTR//intron       25456834//24981863//27371828//27773536//22608085
chrX:106959326-106959327(-) m6A 5'UTR//intron       25456834//24981863//27371828//27773536//22608085
chrX:106959407-106959408(-) m6A 5'UTR//intron       27773536//22608085
chrX:106959434-106959435(-) m6A 5'UTR//intron       27773536
chrX:106959505-106959506(-) m6A 5'UTR//intron       27773536
chrX:106959528-106959529(-) m6A 5'UTR//intron       27773536
chrX:106959643-106959644(-) m6A 5'UTR//intron       25456834//27773536
chrX:106959648-106959649(-) m6A 5'UTR//intron       25456834//27773536
chrX:106959700-106959701(-) m6A 5'UTR//intron       27773536
chrX:106960019-106960020(-) m6A CDS//intron       24981863//28052920//27371828//27773536
chrX:106960036-106960037(-) m6A CDS//intron       24981863//28052920//27371828//27773536
chrX:106960071-106960072(-) m6A 5'UTR//intron       24981863//27371828//27773536
chrX:106960146-106960147(-) m6A 5'UTR//intron       24981863//27371828//27773536
chrX:106960278-106960279(-) m6A 5'UTR//intron       27371828//27773536
chrX:107018473-107018474(-) m6A 5'UTR//CDS       27773536//22608085
chrX:107018539-107018540(-) m6A CDS//intron       27371828//27773536//22608085
chrX:107018584-107018585(-) m6A CDS//intron       27371828//27773536//22608085
chrX:107018970-107018971(-) m6A 5'UTR//intron       24284625//27773536
chrX:107018977-107018978(-) m6A 5'UTR//intron       27773536
chrX:107019098-107019099(-) m6A 5'UTR//intron       27773536
chrX:107019184-107019185(-) m6A 5'UTR//intron       27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate TSC22D3
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: TSC22D3

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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