Detail Information

Basic Information:


  VIRBase ID:  

VHID00502599

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           DHODH:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p DHODH
miRBase
Accession/Entrez ID		 MIMAT0001581 1723
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - DHOdehase//POADS//URA1

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR DHODH
chr16:72058675(+) A-I      3'UTR
chr16:72053020(+) A-I      intronic
chr16:72058716(+) A-I      3'UTR
chr16:72058737(+) A-I      3'UTR
chr16:72058725(+) A-I      3'UTR
chr16:72058705(+) A-I      3'UTR
chr16:72058689(+) A-I      3'UTR
chr16:72051562(+) A-I      intronic
chr16:72058652(+) A-I      3'UTR
chr16:72058850(+) A-I      3'UTR
chr16:72058691(+) A-I      3'UTR
chr16:72058690(+) A-I      3'UTR
chr16:72058647(+) A-I      3'UTR
chr16:72058741(+) A-I      3'UTR
chr16:72058620(+) A-I      3'UTR
chr16:72055845(+) A-I      intronic
chr16:72055871(+) A-I      intronic
chr16:72053107(+) A-I      intronic
chr16:72054388(+) A-I      intronic
chr16:72053808(+) A-I      intronic
chr16:72055841(+) A-I      intronic
chr16:72053922(+) A-I      intronic
chr16:72058717(+) A-I      3'UTR
chr16:72045336(+) A-I      intronic
chr16:72054440(+) A-I      intronic
chr16:72051860(+) A-I      intronic
chr16:72054064(+) A-I      intronic
chr16:72043882(+) A-I      intronic
chr16:72044899(+) A-I      intronic
chr16:72045309(+) A-I      intronic
chr16:72052984(+) A-I      intronic
chr16:72054512(+) A-I      intronic
chr16:72053813(+) A-I      intronic
chr16:72052972(+) A-I      intronic
chr16:72051880(+) A-I      intronic
chr16:72054013(+) A-I      intronic
chr16:72054157(+) A-I      intronic
chr16:72054068(+) A-I      intronic
chr16:72054100(+) A-I      intronic
chr16:72045399(+) A-I      intronic
chr16:72054087(+) A-I      intronic
chr16:72054486(+) A-I      intronic
chr16:72052955(+) A-I      intronic
chr16:72053777(+) A-I      intronic
chr16:72053786(+) A-I      intronic
chr16:72055698(+) A-I      intronic
chr16:72052924(+) A-I      intronic
chr16:72052934(+) A-I      intronic
chr16:72055956(+) A-I      intronic
chr16:72054331(+) A-I      intronic
chr16:72054055(+) A-I      intronic
chr16:72043899(+) A-I      intronic
chr16:72058721(+) A-I      3'UTR
chr16:72058757(+) A-I      3'UTR
chr16:72058709(+) A-I      3'UTR
chr16:72058748(+) A-I      3'UTR
chr16:72058753(+) A-I      3'UTR
chr16:72058856(+) A-I      3'UTR
chr16:72058711(+) A-I      3'UTR
chr16:72058612(+) A-I      3'UTR
chr16:72058715(+) A-I      3'UTR
chr16:72058714(+) A-I      3'UTR
chr16:72058611(+) A-I      3'UTR
chr16:72058780(+) A-I      3'UTR
chr16:72058818(+) A-I      3'UTR
chr16:72058702(+) A-I      3'UTR
chr16:72058817(+) A-I      3'UTR
chr16:72058747(+) A-I      3'UTR
chr16:72058774(+) A-I      3'UTR
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED DHODH
chr16:72052933(+) A-I intron -    22327324
chr16:72058817(+) A-I intron -    22327324
chr16:72051567(+) T-C intron -    22484847
chr16:72052933(+) T-C intron -    22484847
chr16:72053790(+) T-C intron -    22484847
chr16:72053808(+) A-G intron -    22484847
chr16:72054055(+) A-G intron -    22484847
chr16:72054064(+) A-G intron -    22484847
chr16:72054068(+) A-G intron -    22484847
chr16:72054393(+) T-C intron -    22484847
chr16:72054399(+) T-C intron -    22484847
chr16:72054440(+) A-G intron -    22484847
chr16:72055870(+) T-C intron -    22484847
chr16:72058611(+) A-G intron -    22484847
chr16:72058711(+) A-G intron -    22484847
chr16:72058748(+) A-G intron -    22484847
chr16:72058817(+) A-G intron -    22484847
chr16:72058818(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase DHODH
chr16:72042634-72042635(+) m6A 5'UTR       24981863
chr16:72042674-72042675(+) m6A CDS       24981863
chr16:72042717-72042718(+) m6A 5'UTR//intron       24981863
chr16:72042724-72042725(+) m6A 5'UTR//intron       24981863
chr16:72042768-72042769(+) m6A 5'UTR//intron       24981863
chr16:72043014-72043015(+) m6A 5'UTR//intron       25456834//24981863
chr16:72043025-72043026(+) m6A 5'UTR//intron       25456834//24981863
chr16:72045989-72045990(+) m6A 5'UTR//CDS       25456834//24981863
chr16:72046043-72046044(+) m6A CDS       25456834
chr16:72046075-72046076(+) m6A CDS       -
chr16:72048454-72048455(+) m6A 3'UTR//CDS//exon       24981863
chr16:72048505-72048506(+) m6A 3'UTR//CDS//exon       24981863
chr16:72049772-72049773(+) m6A exon//intron       27773535
chr16:72050541-72050542(+) m6A exon//intron       27773535
chr16:72050958-72050959(+) m6A 3'UTR//CDS//exon       24981863
chr16:72050976-72050977(+) m6A 3'UTR//CDS//exon       24981863
chr16:72056351-72056352(+) m6A CDS//intron       24284625
chr16:72057091-72057092(+) m6A CDS//exon//intron       24284625
chr16:72057514-72057515(+) m6A CDS//exon//intron       24284625//24209618//22608085
chr16:72058100-72058101(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085
chr16:72058129-72058130(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085
chr16:72058141-72058142(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085
chr16:72058180-72058181(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr16:72058285-72058286(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr16:72058292-72058293(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr16:72058299-72058300(+) Y 3'UTR//exon       26075521
chr16:72058321-72058322(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr16:72058348-72058349(+) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22608085
chr16:72058398-72058399(+) m6A 3'UTR//exon       24284625//24981863//22608085
chr16:72058504-72058505(+) m6A 3'UTR       24981863
chr16:72058554-72058555(+) m6A 3'UTR       24981863
chr16:72058577-72058578(+) m6A 3'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate DHODH
Chromatin K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: DHODH

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

Starting a new search, please wait ...