Detail Information

Basic Information:


  VIRBase ID:  

VHID00502433

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           CSNK2A2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p CSNK2A2
miRBase
Accession/Entrez ID		 MIMAT0001581 1459
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - CK2A2//CK2alpha'//CSNK2A1

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CSNK2A2
chr16:58205847(-) A-I      intronic
chr16:58205839(-) A-I      intronic
chr16:58205872(-) A-I      intronic
chr16:58203390(-) A-I      intronic
chr16:58205821(-) A-I      intronic
chr16:58203850(-) A-I      intronic
chr16:58205344(-) A-I      intronic
chr16:58205278(-) A-I      intronic
chr16:58203372(-) A-I      intronic
chr16:58203352(-) A-I      intronic
chr16:58203351(-) A-I      intronic
chr16:58203119(-) A-I      intronic
chr16:58202952(-) A-I      intronic
chr16:58202891(-) A-I      intronic
chr16:58205345(-) A-I      intronic
chr16:58203193(-) A-I      intronic
chr16:58205972(-) A-I      intronic
chr16:58203358(-) A-I      intronic
chr16:58203009(-) A-I      intronic
chr16:58203276(-) A-I      intronic
chr16:58203744(-) A-I      intronic
chr16:58205303(-) A-I      intronic
chr16:58203199(-) A-I      intronic
chr16:58203365(-) A-I      intronic
chr16:58205777(-) A-I      intronic
chr16:58213293(-) A-I      intronic
chr16:58205341(-) A-I      intronic
chr16:58206022(-) A-I      intronic
chr16:58203097(-) A-I      intronic
chr16:58203011(-) A-I      intronic
chr16:58203187(-) A-I      intronic
chr16:58206002(-) A-I      intronic
chr16:58203382(-) A-I      intronic
chr16:58205992(-) A-I      intronic
chr16:58203334(-) A-I      intronic
chr16:58216178(-) A-I      intronic
chr16:58203842(-) A-I      intronic
chr16:58203874(-) A-I      intronic
chr16:58205258(-) A-I      intronic
chr16:58203008(-) A-I      intronic
chr16:58212285(-) A-I      intronic
chr16:58205172(-) A-I      intronic
chr16:58212291(-) A-I      intronic
chr16:58203295(-) A-I      intronic
chr16:58205315(-) A-I      intronic
chr16:58205264(-) A-I      intronic
chr16:58202969(-) A-I      intronic
chr16:58202942(-) A-I      intronic
chr16:58202842(-) A-I      intronic
chr16:58205841(-) A-I      intronic
chr16:58203109(-) A-I      intronic
chr16:58213296(-) A-I      intronic
chr16:58203911(-) A-I      intronic
chr16:58213403(-) A-I      intronic
chr16:58202998(-) A-I      intronic
chr16:58202985(-) A-I      intronic
chr16:58202916(-) A-I      intronic
chr16:58203010(-) A-I      intronic
chr16:58203766(-) A-I      intronic
chr16:58212280(-) A-I      intronic
chr16:58202928(-) A-I      intronic
chr16:58205287(-) A-I      intronic
chr16:58205222(-) A-I      intronic
chr16:58203102(-) A-I      intronic
chr16:58205247(-) A-I      intronic
chr16:58203841(-) A-I      intronic
chr16:58230414(-) A-I      intronic
chr16:58203059(-) A-I      intronic
chr16:58203247(-) A-I      intronic
chr16:58203786(-) A-I      intronic
chr16:58230402(-) A-I      intronic
chr16:58205184(-) A-I      intronic
chr16:58202979(-) A-I      intronic
chr16:58203309(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED CSNK2A2
chr16:58202916(-) A-I intron -    22327324
chr16:58203358(-) A-G intron -    22484847
chr16:58203365(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CSNK2A2
chr16:58191908-58191909(-) m6A 3'UTR//exon       24981863//27773535
chr16:58191932-58191933(-) m6A 3'UTR//exon       24981863//27773535
chr16:58192094-58192095(-) m6A 3'UTR//exon       24284625//24981863//27773535
chr16:58192128-58192129(-) m6A 3'UTR//exon       24284625//24981863//27773535
chr16:58192133-58192134(-) m6A 3'UTR//exon       24284625//24981863//27773535
chr16:58192165-58192166(-) m6A 3'UTR//exon       24981863//27773535
chr16:58192215-58192216(-) m6A 3'UTR//exon       27773535
chr16:58192221-58192222(-) m6A 3'UTR//exon       27773535
chr16:58193463-58193464(-) m6A 3'UTR//intron       27773535
chr16:58193606-58193607(-) m6A 3'UTR//intron       24284625//27773535//22575960//22608085
chr16:58193687-58193688(-) m6A 3'UTR//intron       24284625//25456834//24981863//27773535//27371828//22575960//22608085
chr16:58193706-58193707(-) m6A 3'UTR//intron       24284625//25456834//24981863//27773535//27371828//22575960//22608085
chr16:58193732-58193733(-) m6A 3'UTR//intron       24284625//25456834//24981863//27773535//22575960//22608085
chr16:58193808-58193809(-) m6A 3'UTR//intron       24284625//24981863//27773535//22608085
chr16:58193847-58193848(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr16:58193885-58193886(-) m6A 3'UTR//intron       27773535//22608085
chr16:58193963-58193964(-) m6A 3'UTR//intron       27773535//22608085
chr16:58194050-58194051(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr16:58194096-58194097(-) m6A 3'UTR//intron       24981863//28052920//27773535//22608085
chr16:58194149-58194150(-) m6A 3'UTR//intron       24981863//28052920//27773535//22608085
chr16:58194173-58194174(-) m6A 3'UTR//intron       24981863//28052920//27773535
chr16:58194236-58194237(-) m6A 3'UTR//intron       24981863//27773535
chr16:58194244-58194245(-) m6A 3'UTR//intron       24981863//27773535
chr16:58194274-58194275(-) m6A 3'UTR//intron       27773535
chr16:58194348-58194349(-) m6A 3'UTR//intron       27773535
chr16:58194664-58194665(-) m6A 3'UTR//intron       24981863//27773535
chr16:58194708-58194709(-) m6A 3'UTR//intron       24981863//27773535
chr16:58194725-58194726(-) m6A 3'UTR//intron       24981863//27773535
chr16:58194733-58194734(-) m6A 3'UTR//intron       24981863//27773535
chr16:58194751-58194752(-) m6A 3'UTR//intron       24981863//27773535
chr16:58194825-58194826(-) m6A 3'UTR//intron       27773535
chr16:58194856-58194857(-) m6A 3'UTR//intron       27773535
chr16:58195535-58195536(-) m6A 3'UTR//intron       27773535
chr16:58195559-58195560(-) m6A 3'UTR//intron       27773535
chr16:58195576-58195577(-) m6A 3'UTR//intron       27773535
chr16:58195601-58195602(-) m6A 3'UTR//intron       27773535
chr16:58195623-58195624(-) m6A 3'UTR//intron       24284625//27773535
chr16:58195693-58195694(-) m6A 3'UTR//intron       24284625//27773535
chr16:58195969-58195970(-) m6A 3'UTR//intron       -
chr16:58197700-58197701(-) m6A 3'UTR//intron       24981863//22608085
chr16:58197805-58197806(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr16:58197836-58197837(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//27371828//22608085
chr16:58197895-58197896(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//27371828//22608085
chr16:58197908-58197909(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22608085
chr16:58197914-58197915(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22608085
chr16:58197927-58197928(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22608085
chr16:58197971-58197972(-) m6A 3'UTR//exon       24284625//24981863//27773535//22608085
chr16:58198014-58198015(-) m6A CDS//exon       24284625//24981863//27773535//22575960
chr16:58199500-58199501(-) m6A CDS//exon       27773535
chr16:58199531-58199532(-) m6A CDS//exon       27773535
chr16:58199570-58199571(-) m6A CDS//exon       27773535
chr16:58199588-58199589(-) m6A CDS//exon       27773535
chr16:58200489-58200490(-) m6A CDS//exon       27773535
chr16:58200520-58200521(-) m6A CDS//exon       27773535
chr16:58200552-58200553(-) m6A CDS//exon       27773535
chr16:58220665-58220666(-) m6A CDS//exon       27773535
chr16:58220699-58220700(-) m6A CDS//exon       27773535
chr16:58220713-58220714(-) m6A CDS//exon       27773535
chr16:58230717-58230718(-) m6A CDS       24209618//27773535
chr16:58231563-58231564(-) m6A CDS       24209618//27773535
chr16:58231590-58231591(-) m6A CDS       24209618//27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate CSNK2A2
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)|HeLa-S3 cells     -
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)     -
Membrane HCC cell line (HepG2)     -
Nucleoplasm K562 cells     -
Nucleus K562 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: CSNK2A2

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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