Detail Information

Basic Information:


  VIRBase ID:  

VHID00502279

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           CCR7:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p CCR7
miRBase
Accession/Entrez ID		 MIMAT0001581 1236
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - BLR2//CC-CKR-7//CCR-7//CD197//CDw197//CMKBR7//EBI1

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CCR7
chr17:38713987(-) A-I      intronic
chr17:38713981(-) A-I      intronic
chr17:38713982(-) A-I      intronic
chr17:38714005(-) A-I      intronic
chr17:38713986(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CCR7
chr17:38710149-38710150(-) m6A 3'UTR       24981863//28052920//27371828
chr17:38710156-38710157(-) m6A 3'UTR       24981863//28052920//27371828
chr17:38710237-38710238(-) m6A 3'UTR       27371828
chr17:38710482-38710483(-) m6A 3'UTR       24981863//28052920//26404942//27371828
chr17:38710495-38710496(-) m6A 3'UTR       24981863//28052920//26404942//27371828
chr17:38710510-38710511(-) m6A 3'UTR       24981863//28052920//26404942//27371828
chr17:38710537-38710538(-) m6A 3'UTR       25456834//24981863//28052920//26404942//27371828
chr17:38710555-38710556(-) m6A 3'UTR       25456834//24981863//28052920//26404942//27371828
chr17:38710574-38710575(-) m6A 3'UTR       25456834//24981863//28052920//26404942//27371828
chr17:38710590-38710591(-) m6A 3'UTR       25456834//24981863//28052920//26404942//27371828
chr17:38710604-38710605(-) m6A 3'UTR       25456834//24981863//28052920//26404942//27371828
chr17:38710623-38710624(-) m6A 3'UTR       24981863//28052920//26404942//27371828
chr17:38710706-38710707(-) m6A 3'UTR       24981863//28052920//26404942//27371828
chr17:38710727-38710728(-) m6A 3'UTR       24981863//28052920//26404942//27371828
chr17:38710734-38710735(-) m6A 3'UTR       24981863//28052920//26404942//27371828
chr17:38710755-38710756(-) m6A 3'UTR       24981863//28052920//26404942//27371828
chr17:38710772-38710773(-) m6A 3'UTR       24981863//28052920//26404942//27371828
chr17:38710796-38710797(-) m6A 3'UTR       24981863//28052920//26404942//27371828
chr17:38710913-38710914(-) m6A 3'UTR       25456834//24981863//28052920//26404942//27371828
chr17:38710966-38710967(-) m6A 3'UTR       24981863//28052920//26404942//27371828
chr17:38710975-38710976(-) m6A 3'UTR       24981863//28052920//26404942//27371828
chr17:38711016-38711017(-) m6A CDS       24981863//28052920//27371828
chr17:38711102-38711103(-) m6A CDS       27371828
chr17:38711819-38711820(-) m6A CDS       28052920//26404942
chr17:38711859-38711860(-) m6A CDS       28052920//26404942
chr17:38711966-38711967(-) m6A 5'UTR//CDS       24284625//24981863//28052920//26404942//27371828
chr17:38712011-38712012(-) m6A 5'UTR//CDS       24284625//24981863//28052920//26404942//27371828
chr17:38712026-38712027(-) m6A 5'UTR//CDS       24284625//24981863//28052920//26404942//27371828
chr17:38715189-38715190(-) m6A 5'UTR//CDS//intron       28052920//27371828
chr17:38716998-38716999(-) m6A 5'UTR//intron       27371828
chr17:38717003-38717004(-) m6A 5'UTR//intron       27371828
chr17:38717013-38717014(-) m6A 5'UTR//intron       27371828
chr17:38717070-38717071(-) m6A 5'UTR//intron       -
chr17:38717106-38717107(-) m6A 5'UTR//intron       -
chr17:38717189-38717190(-) m6A 5'UTR//intron       -
chr17:38717195-38717196(-) m6A 5'UTR//intron       -
chr17:38717227-38717228(-) m6A 5'UTR//intron       -
chr17:38721656-38721657(-) m6A 5'UTR//CDS       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate CCR7
Exosome Blood     -

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: CCR7

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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