Basic Information:

  VIRBase ID:  

VHID00502277

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          CCR5:  NM_000579     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	CCR5
miRBase Accession/Entrez ID	MIMAT0001581	1234
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	CC-CKR-5//CCCKR5//CCR-5//CD195//CKR-5//CKR5//CMKBR5//IDDM22

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CCR5	chr3:46417215(+) A-I      3'UTR chr3:46417221(+) A-I      3'UTR chr3:46417219(+) A-I      3'UTR chr3:46417218(+) A-I      3'UTR chr3:46417270(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CCR5	chr3:46417171(+) A-I exon 3'UTR    15258596 chr3:46417220(+) A-I exon 3'UTR    15258596 chr3:46417272(+) A-I exon 3'UTR    15258596 chr3:46417283(+) A-I exon 3'UTR    15258596

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CCR5	chr3:46414562-46414563(+) m6A CDS       - chr3:46414676-46414677(+) m6A CDS       - chr3:46415165-46415166(+) m6A CDS       - chr3:46415219-46415220(+) m6A CDS       - chr3:46415242-46415243(+) m6A CDS       - chr3:46415309-46415310(+) m6A CDS       - chr3:46415457-46415458(+) m6A 3'UTR       - chr3:46416453-46416454(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	CCR5	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: CCR5

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.