Basic Information:

  VIRBase ID:  

VHID00502184

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7903

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          CFL2:  NR_028131     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	CFL2
miRBase Accession/Entrez ID	MIMAT0001581	1073
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	NEM7

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CFL2	chr14:35179597-35179598(-) m6A 3'UTR       27773535 chr14:35179614-35179615(-) m6A 3'UTR       27773535 chr14:35181516-35181517(-) Y 3'UTR       26075521 chr14:35181827-35181828(-) m6A 3'UTR       26404942 chr14:35181863-35181864(-) m6A 3'UTR       26404942 chr14:35181892-35181893(-) m6A 3'UTR       26404942 chr14:35182079-35182080(-) m6A 3'UTR//CDS       24981863//26404942 chr14:35182118-35182119(-) Gm 3'UTR//CDS       - chr14:35182137-35182138(-) m6A 3'UTR//CDS       24981863//26404942 chr14:35182175-35182176(-) m6A 3'UTR//CDS       24981863//26404942 chr14:35182477-35182478(-) m6A CDS//intron       27773535 chr14:35182499-35182500(-) m6A CDS//intron       27773535 chr14:35182573-35182574(-) m6A CDS//intron       24981863//26404942//27773535//22608085 chr14:35182635-35182636(-) m6A CDS//intron       24981863//27773535//22608085 chr14:35182942-35182943(-) m6A 5'UTR//intron       24981863//22608085 chr14:35182979-35182980(-) m6A 5'UTR//intron       24981863 chr14:35183934-35183935(-) m6A 5'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	CFL2	Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleus HeLa-S3 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: CFL2

Evidence Support:

Strong-Evidence	RISC-IP
Prediction-Evidence	miRanda//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.