Basic Information:

  VIRBase ID:  

VHID00502149

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          CDKN1B:  NM_004064     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	CDKN1B
miRBase Accession/Entrez ID	MIMAT0001581	1027
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	CDKN4//KIP1//MEN1B//MEN4//P27KIP1

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CDKN1B	chr12:12868290(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CDKN1B	chr12:12870457-12870458(+) m6A 5'UTR//intron       24284625//24981863//22575960//22608085 chr12:12870481-12870482(+) m6A 5'UTR//intron       24284625//24981863//22575960//22608085 chr12:12870568-12870569(+) m6A 5'UTR//intron       - chr12:12870760-12870761(+) m6A 5'UTR//intron       24209618//24981863//22608085 chr12:12870864-12870865(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr12:12870882-12870883(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr12:12870903-12870904(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr12:12870921-12870922(+) Gm CDS//intron       - chr12:12870924-12870925(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr12:12870976-12870977(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr12:12871042-12871043(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr12:12871152-12871153(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr12:12871167-12871168(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr12:12871175-12871176(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr12:12871188-12871189(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr12:12871773-12871774(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr12:12871790-12871791(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr12:12871880-12871881(+) m6A 3'UTR//exon//intron       24284625//24981863//22608085 chr12:12874075-12874076(+) m6A 3'UTR//CDS//exon       24284625//24981863//26404942//22608085 chr12:12874098-12874099(+) m6A 3'UTR//CDS//exon       24284625//24981863//26404942//27773535//22608085 chr12:12874247-12874248(+) m6A 3'UTR       24981863//22608085 chr12:12874282-12874283(+) m6A 3'UTR       24981863 chr12:12875101-12875102(+) m6A 3'UTR       27773535 chr12:12875290-12875291(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	CDKN1B	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: CDKN1B

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.