Basic Information:

  VIRBase ID:  

VHID00502039

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7903

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          CCND2:  NM_001759     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	CCND2
miRBase Accession/Entrez ID	MIMAT0001581	894
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	KIAK0002//MPPH3

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CCND2	chr12:4407683(+) A-I      intronic chr12:4406504(+) A-I      intronic chr12:4408273(+) A-I      intronic chr12:4408319(+) A-I      intronic chr12:4407661(+) A-I      intronic chr12:4408272(+) A-I      intronic chr12:4406535(+) A-I      intronic chr12:4408325(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CCND2	chr12:4406341(+) A-T intron -    22484847 chr12:4406592(+) C-T intron -    22484847 chr12:4406734(+) C-T intron -    22484847 chr12:4406735(+) T-C intron -    22484847 chr12:4406736(+) C-A intron -    22484847 chr12:4407661(+) A-G intron -    22484847 chr12:4404682(+) T-C intron -    22484847 chr12:4408272(+) A-G intron -    22484847 chr12:4408273(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CCND2	chr12:4382959-4382960(+) m6A 5'UTR       25456834//24981863 chr12:4382977-4382978(+) m6A 5'UTR       25456834//24981863 chr12:4383080-4383081(+) m6A 5'UTR       25456834//24981863 chr12:4383140-4383141(+) m6A 5'UTR       24981863 chr12:4383146-4383147(+) m6A 5'UTR       - chr12:4383154-4383155(+) m6A 5'UTR       - chr12:4409504-4409505(+) m6A 3'UTR       22608085 chr12:4409518-4409519(+) m6A 3'UTR       24981863//22608085 chr12:4409578-4409579(+) m6A 3'UTR       24209618//24981863//22608085 chr12:4409622-4409623(+) m6A 3'UTR       24209618//24981863//22608085 chr12:4409650-4409651(+) m6A 3'UTR       24209618//24981863//22608085 chr12:4409673-4409674(+) m6A 3'UTR       24209618//24981863//22608085 chr12:4409694-4409695(+) m6A 3'UTR       24209618//24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	CCND2	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: CCND2

Evidence Support:

Strong-Evidence	RISC-IP
Prediction-Evidence	miRanda//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.