Basic Information:

  VIRBase ID:  

VHID00501981

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          CALU:  NR_074086     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	CALU
miRBase Accession/Entrez ID	MIMAT0001581	813
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CALU	chr7:128406164(+) A-I      intronic chr7:128406531(+) A-I      intronic chr7:128406622(+) A-I      intronic chr7:128386649(+) A-I      intronic chr7:128406050(+) A-I      intronic chr7:128406798(+) A-I      intronic chr7:128406072(+) A-I      intronic chr7:128403510(+) A-I      intronic chr7:128403505(+) A-I      intronic chr7:128403497(+) A-I      intronic chr7:128403491(+) A-I      intronic chr7:128403452(+) A-I      intronic chr7:128402942(+) A-I      intronic chr7:128402866(+) A-I      intronic chr7:128402838(+) A-I      intronic chr7:128402764(+) A-I      intronic chr7:128402760(+) A-I      intronic chr7:128392948(+) A-I      intronic chr7:128392936(+) A-I      intronic chr7:128392884(+) A-I      intronic chr7:128392839(+) A-I      intronic chr7:128392838(+) A-I      intronic chr7:128392778(+) A-I      intronic chr7:128391670(+) A-I      intronic chr7:128391262(+) A-I      intronic chr7:128390242(+) A-I      intronic chr7:128390237(+) A-I      intronic chr7:128390188(+) A-I      intronic chr7:128390167(+) A-I      intronic chr7:128390135(+) A-I      intronic chr7:128387102(+) A-I      intronic chr7:128386940(+) A-I      intronic chr7:128386938(+) A-I      intronic chr7:128386903(+) A-I      intronic chr7:128386647(+) A-I      intronic chr7:128386637(+) A-I      intronic chr7:128386473(+) A-I      intronic chr7:128385645(+) A-I      intronic chr7:128385622(+) A-I      intronic chr7:128385538(+) A-I      intronic chr7:128385424(+) A-I      intronic chr7:128384166(+) A-I      intronic chr7:128384153(+) A-I      intronic chr7:128383750(+) A-I      intronic chr7:128380984(+) A-I      intronic chr7:128406692(+) A-I      intronic chr7:128406666(+) A-I      intronic chr7:128406612(+) A-I      intronic chr7:128406583(+) A-I      intronic chr7:128402862(+) A-I      intronic chr7:128404395(+) A-I      intronic chr7:128404489(+) A-I      intronic chr7:128405076(+) A-I      intronic chr7:128405157(+) A-I      intronic chr7:128405204(+) A-I      intronic chr7:128405342(+) A-I      intronic chr7:128406111(+) A-I      intronic chr7:128409667(+) A-I      3'UTR chr7:128403336(+) A-I      intronic chr7:128391073(+) A-I      intronic chr7:128393013(+) A-I      intronic chr7:128392758(+) A-I      intronic chr7:128385544(+) A-I      intronic chr7:128384005(+) A-I      intronic chr7:128392868(+) A-I      intronic chr7:128390093(+) A-I      intronic chr7:128400699(+) A-I      intronic chr7:128391599(+) A-I      intronic chr7:128402906(+) A-I      intronic chr7:128391638(+) A-I      intronic chr7:128386401(+) A-I      intronic chr7:128392904(+) A-I      intronic chr7:128405121(+) A-I      intronic chr7:128405492(+) A-I      intronic chr7:128385548(+) A-I      intronic chr7:128399996(+) A-I      intronic chr7:128406110(+) A-I      intronic chr7:128392809(+) A-I      intronic chr7:128406064(+) A-I      intronic chr7:128405007(+) A-I      intronic chr7:128402850(+) A-I      intronic chr7:128404296(+) A-I      intronic chr7:128404321(+) A-I      intronic chr7:128403418(+) A-I      intronic chr7:128385585(+) A-I      intronic chr7:128385608(+) A-I      intronic chr7:128406151(+) A-I      intronic chr7:128403424(+) A-I      intronic chr7:128402995(+) A-I      intronic chr7:128386486(+) A-I      intronic chr7:128405449(+) A-I      intronic chr7:128406663(+) A-I      intronic chr7:128404372(+) A-I      intronic chr7:128405354(+) A-I      intronic chr7:128392832(+) A-I      intronic chr7:128383694(+) A-I      intronic chr7:128383732(+) A-I      intronic chr7:128386758(+) A-I      intronic chr7:128400089(+) A-I      intronic chr7:128386655(+) A-I      intronic chr7:128393005(+) A-I      intronic chr7:128386474(+) A-I      intronic chr7:128406030(+) A-I      intronic chr7:128384101(+) A-I      intronic chr7:128405368(+) A-I      intronic chr7:128404421(+) A-I      intronic chr7:128384004(+) A-I      intronic chr7:128392939(+) A-I      intronic chr7:128391088(+) A-I      intronic chr7:128386780(+) A-I      intronic chr7:128383689(+) A-I      intronic chr7:128404213(+) A-I      intronic chr7:128402814(+) A-I      intronic chr7:128391660(+) A-I      intronic chr7:128383716(+) A-I      intronic chr7:128383832(+) A-I      intronic chr7:128405125(+) A-I      intronic chr7:128404414(+) A-I      intronic chr7:128390026(+) A-I      intronic chr7:128403427(+) A-I      intronic chr7:128383820(+) A-I      intronic chr7:128406137(+) A-I      intronic chr7:128393006(+) A-I      intronic chr7:128386608(+) A-I      intronic chr7:128392922(+) A-I      intronic chr7:128405048(+) A-I      intronic chr7:128385532(+) A-I      intronic chr7:128404350(+) A-I      intronic chr7:128391283(+) A-I      intronic chr7:128404432(+) A-I      intronic chr7:128404437(+) A-I      intronic chr7:128405306(+) A-I      intronic chr7:128386329(+) A-I      intronic chr7:128405458(+) A-I      intronic chr7:128403422(+) A-I      intronic chr7:128403397(+) A-I      intronic chr7:128400708(+) A-I      intronic chr7:128390161(+) A-I      intronic chr7:128386351(+) A-I      intronic chr7:128386274(+) A-I      intronic chr7:128393018(+) A-I      intronic chr7:128384156(+) A-I      intronic chr7:128404342(+) A-I      intronic chr7:128402998(+) A-I      intronic chr7:128392878(+) A-I      intronic chr7:128406216(+) A-I      intronic chr7:128402860(+) A-I      intronic chr7:128392808(+) A-I      intronic chr7:128402901(+) A-I      intronic chr7:128391292(+) A-I      intronic chr7:128392789(+) A-I      intronic chr7:128402798(+) A-I      intronic chr7:128403436(+) A-I      intronic chr7:128391195(+) A-I      intronic chr7:128402930(+) A-I      intronic chr7:128393036(+) A-I      intronic chr7:128406762(+) A-I      intronic chr7:128403423(+) A-I      intronic chr7:128391221(+) A-I      intronic chr7:128404467(+) A-I      intronic chr7:128403464(+) A-I      intronic chr7:128406199(+) A-I      intronic chr7:128383626(+) A-I      intronic chr7:128400074(+) A-I      intronic chr7:128386962(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CALU	chr7:128392868(+) A-I intron -    15258596 chr7:128392873(+) A-I intron -    15258596 chr7:128392878(+) A-I intron -    15258596 chr7:128393006(+) A-I intron -    15258596 chr7:128393013(+) A-I intron -    15258596 chr7:128393018(+) A-I intron -    15258596 chr7:128384005(+) A-I intron -    22327324 chr7:128405306(+) A-I intron -    22327324 chr7:128391674(+) A-I intron -    21960545 chr7:128406110(+) A-I intron -    21960545 chr7:128406151(+) A-I intron -    21960545 chr7:128385418(+) A-I intron -    21960545 chr7:128390026(+) A-I intron -    21960545 chr7:128405007(+) A-I intron -    21960545 chr7:128405048(+) A-I intron -    21960545 chr7:128383694(+) A-G intron -    22484847 chr7:128383732(+) A-G intron -    22484847 chr7:128383991(+) A-G intron -    22484847 chr7:128384004(+) A-G intron -    22484847 chr7:128384005(+) A-G intron -    22484847 chr7:128384100(+) A-G intron -    22484847 chr7:128384101(+) A-G intron -    22484847 chr7:128384140(+) A-G intron -    22484847 chr7:128385419(+) A-G intron -    22484847 chr7:128385532(+) A-G intron -    22484847 chr7:128385562(+) A-G intron -    22484847 chr7:128386274(+) A-G intron -    22484847 chr7:128386401(+) A-G intron -    22484847 chr7:128386608(+) A-G intron -    22484847 chr7:128390003(+) A-G intron -    22484847 chr7:128390161(+) A-G intron -    22484847 chr7:128391089(+) A-G intron -    22484847 chr7:128391094(+) A-G intron -    22484847 chr7:128391195(+) A-G intron -    22484847 chr7:128391221(+) A-G intron -    22484847 chr7:128392808(+) A-G intron -    22484847 chr7:128392809(+) A-G intron -    22484847 chr7:128392832(+) A-G intron -    22484847 chr7:128392868(+) A-G intron -    22484847 chr7:128392873(+) A-G intron -    22484847 chr7:128392878(+) A-G intron -    22484847 chr7:128392904(+) A-G intron -    22484847 chr7:128392922(+) A-G intron -    22484847 chr7:128392939(+) A-G intron -    22484847 chr7:128393006(+) A-G intron -    22484847 chr7:128393013(+) A-G intron -    22484847 chr7:128402798(+) A-G intron -    22484847 chr7:128402814(+) A-G intron -    22484847 chr7:128402820(+) A-G intron -    22484847 chr7:128402860(+) A-G intron -    22484847 chr7:128402901(+) A-G intron -    22484847 chr7:128402902(+) A-G intron -    22484847 chr7:128402904(+) A-G intron -    22484847 chr7:128402906(+) A-G intron -    22484847 chr7:128402983(+) A-G intron -    22484847 chr7:128402998(+) A-G intron -    22484847 chr7:128403335(+) A-G intron -    22484847 chr7:128403407(+) A-G intron -    22484847 chr7:128403418(+) A-G intron -    22484847 chr7:128403421(+) A-G intron -    22484847 chr7:128403422(+) A-G intron -    22484847 chr7:128403423(+) A-G intron -    22484847 chr7:128403424(+) A-G intron -    22484847 chr7:128403425(+) A-G intron -    22484847 chr7:128403427(+) A-G intron -    22484847 chr7:128403464(+) A-G intron -    22484847 chr7:128404350(+) A-G intron -    22484847 chr7:128404372(+) A-G intron -    22484847 chr7:128404421(+) A-G intron -    22484847 chr7:128404432(+) A-G intron -    22484847 chr7:128404467(+) A-G intron -    22484847 chr7:128405007(+) A-G intron -    22484847 chr7:128405048(+) A-G intron -    22484847 chr7:128405306(+) A-G intron -    22484847 chr7:128405354(+) A-G intron -    22484847 chr7:128406064(+) A-G intron -    22484847 chr7:128406199(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CALU	chr7:128379391-128379392(+) m6A 5'UTR       24981863 chr7:128387907-128387908(+) m6A 5'UTR//intron       24981863//22608085 chr7:128387949-128387950(+) m6A 5'UTR//intron       25456834//24981863//22608085 chr7:128387991-128387992(+) m6A 5'UTR//intron       25456834//24981863//22608085 chr7:128388048-128388049(+) m6A 5'UTR//intron       24284625//25456834//24981863//22608085 chr7:128388062-128388063(+) m6A 5'UTR//intron       24284625//24981863//22608085 chr7:128388106-128388107(+) m6A 5'UTR//intron       24284625//24209618//24981863//22608085 chr7:128388126-128388127(+) m6A 5'UTR//intron       24284625//24209618//24981863//22608085 chr7:128388164-128388165(+) m6A 5'UTR//intron       24284625//24209618//24981863//22608085 chr7:128388184-128388185(+) m6A 5'UTR//intron       24284625//24209618//24981863//22608085 chr7:128388229-128388230(+) m6A 5'UTR//intron       24284625//24981863//22608085 chr7:128388234-128388235(+) m6A 5'UTR//intron       24284625//24981863//22608085 chr7:128388280-128388281(+) m6A 5'UTR//intron       24981863//22608085 chr7:128388311-128388312(+) m6A 5'UTR//intron       22608085 chr7:128388359-128388360(+) m6A 5'UTR//intron       22608085 chr7:128388370-128388371(+) m6A 5'UTR//intron       22608085 chr7:128388696-128388697(+) m6A CDS       27773535 chr7:128388713-128388714(+) m6A CDS       27773535 chr7:128388814-128388815(+) m6A CDS       24981863//26404942//27773535 chr7:128394377-128394378(+) m6A CDS//intron       24981863//26404942//27773535 chr7:128394427-128394428(+) Cm CDS//intron       - chr7:128394692-128394693(+) m6A CDS//intron       27773535 chr7:128398958-128398959(+) m6A CDS       24209618//24981863//26404942//27773535 chr7:128398999-128399000(+) m6A CDS       24209618//24981863//26404942//27773535 chr7:128399011-128399012(+) m6A CDS       24209618//24981863//26404942//27773535 chr7:128399848-128399849(+) m6A CDS       24209618//24981863//26404942//27773535//22575960 chr7:128407559-128407560(+) m6A CDS//intron       24209618//24981863//26404942//27773535//22575960//22608085 chr7:128407596-128407597(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr7:128407607-128407608(+) Am CDS//intron       - chr7:128407614-128407615(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr7:128407625-128407626(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr7:128407632-128407633(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr7:128407650-128407651(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr7:128407698-128407699(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr7:128407704-128407705(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr7:128409232-128409233(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr7:128409303-128409304(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr7:128409316-128409317(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr7:128409326-128409327(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr7:128409347-128409348(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr7:128409382-128409383(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr7:128409409-128409410(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr7:128409544-128409545(+) m6A 3'UTR//intron       26404942//27773535 chr7:128409695-128409696(+) m6A 3'UTR//intron       27773535 chr7:128410044-128410045(+) Y 3'UTR//intron       25219674 chr7:128410416-128410417(+) m6A 3'UTR//intron       26404942//27773535 chr7:128410464-128410465(+) m6A 3'UTR//intron       26404942//27773535 chr7:128410520-128410521(+) Am 3'UTR//intron       - chr7:128410531-128410532(+) m6A 3'UTR//intron       26404942//27773535 chr7:128410560-128410561(+) m6A 3'UTR//intron       24981863//26404942//27773535 chr7:128410714-128410715(+) m6A 3'UTR//intron       27773535 chr7:128410763-128410764(+) m6A 3'UTR//intron       27773535 chr7:128411136-128411137(+) m6A 3'UTR//intron       27773535 chr7:128411191-128411192(+) m6A 3'UTR//intron       27773535 chr7:128411248-128411249(+) Y 3'UTR//intron       26075521 chr7:128411272-128411273(+) m6A 3'UTR//intron       26404942 chr7:128411288-128411289(+) m6A 3'UTR//intron       26404942 chr7:128411377-128411378(+) m6A 3'UTR//intron       26404942

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	CALU	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: CALU

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.