Detail Information

Basic Information:


  VIRBase ID:  

VHID00501855

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           BLMH:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p BLMH
miRBase
Accession/Entrez ID		 MIMAT0001581 642
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - BH//BMH

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR BLMH
chr17:28582868(-) A-I      intronic
chr17:28597435(-) A-I      intronic
chr17:28601743(-) A-I      intronic
chr17:28601752(-) A-I      intronic
chr17:28601756(-) A-I      intronic
chr17:28601765(-) A-I      intronic
chr17:28608754(-) A-I      intronic
chr17:28606782(-) A-I      intronic
chr17:28607602(-) A-I      intronic
chr17:28608745(-) A-I      intronic
chr17:28582832(-) A-I      intronic
chr17:28595792(-) A-I      intronic
chr17:28595833(-) A-I      intronic
chr17:28595872(-) A-I      intronic
chr17:28595892(-) A-I      intronic
chr17:28596363(-) A-I      intronic
chr17:28596406(-) A-I      intronic
chr17:28596412(-) A-I      intronic
chr17:28596426(-) A-I      intronic
chr17:28605852(-) A-I      intronic
chr17:28605856(-) A-I      intronic
chr17:28606744(-) A-I      intronic
chr17:28610096(-) A-I      intronic
chr17:28610172(-) A-I      intronic
chr17:28615738(-) A-I      intronic
chr17:28615739(-) A-I      intronic
chr17:28615963(-) A-I      intronic
chr17:28583021(-) A-I      intronic
chr17:28583552(-) A-I      intronic
chr17:28609165(-) A-I      intronic
chr17:28583101(-) A-I      intronic
chr17:28615482(-) A-I      intronic
chr17:28585124(-) A-I      intronic
chr17:28583178(-) A-I      intronic
chr17:28606768(-) A-I      intronic
chr17:28583526(-) A-I      intronic
chr17:28583194(-) A-I      intronic
chr17:28582815(-) A-I      intronic
chr17:28607633(-) A-I      intronic
chr17:28596301(-) A-I      intronic
chr17:28596014(-) A-I      intronic
chr17:28615536(-) A-I      intronic
chr17:28583069(-) A-I      intronic
chr17:28615413(-) A-I      intronic
chr17:28583527(-) A-I      intronic
chr17:28583200(-) A-I      intronic
chr17:28583124(-) A-I      intronic
chr17:28583132(-) A-I      intronic
chr17:28582710(-) A-I      intronic
chr17:28582829(-) A-I      intronic
chr17:28607659(-) A-I      intronic
chr17:28615638(-) A-I      intronic
chr17:28595975(-) A-I      intronic
chr17:28615928(-) A-I      intronic
chr17:28596307(-) A-I      intronic
chr17:28605755(-) A-I      intronic
chr17:28596011(-) A-I      intronic
chr17:28601875(-) A-I      intronic
chr17:28615414(-) A-I      intronic
chr17:28607587(-) A-I      intronic
chr17:28596284(-) A-I      intronic
chr17:28610678(-) A-I      intronic
chr17:28607592(-) A-I      intronic
chr17:28593431(-) A-I      intronic
chr17:28583068(-) A-I      intronic
chr17:28610174(-) A-I      intronic
chr17:28607605(-) A-I      intronic
chr17:28606814(-) A-I      intronic
chr17:28606811(-) A-I      intronic
chr17:28615954(-) A-I      intronic
chr17:28606751(-) A-I      intronic
chr17:28583043(-) A-I      intronic
chr17:28610128(-) A-I      intronic
chr17:28610153(-) A-I      intronic
chr17:28582748(-) A-I      intronic
chr17:28582735(-) A-I      intronic
chr17:28596292(-) A-I      intronic
chr17:28615443(-) A-I      intronic
chr17:28601991(-) A-I      intronic
chr17:28606763(-) A-I      intronic
chr17:28595889(-) A-I      intronic
chr17:28595976(-) A-I      intronic
chr17:28601733(-) A-I      intronic
chr17:28595639(-) A-I      intronic
chr17:28595863(-) A-I      intronic
chr17:28596343(-) A-I      intronic
chr17:28609948(-) A-I      intronic
chr17:28596478(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED BLMH
chr17:28615638(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase BLMH
chr17:28575316-28575317(-) m6A 3'UTR//exon       27773535
chr17:28575350-28575351(-) m6A 3'UTR//exon       27773535
chr17:28575395-28575396(-) m6A 3'UTR//exon       27773535
chr17:28575409-28575410(-) m6A 3'UTR//exon       27773535
chr17:28575462-28575463(-) m6A 3'UTR//exon       27773535
chr17:28575866-28575867(-) m6A 3'UTR//exon       24284625//25456834//28052920//27773535//27371828//22575960//22608085
chr17:28575896-28575897(-) m6A 3'UTR//exon       24284625//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:28575926-28575927(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:28575944-28575945(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:28575968-28575969(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:28575980-28575981(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:28576000-28576001(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:28576059-28576060(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr17:28576082-28576083(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr17:28576128-28576129(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//22575960//22608085
chr17:28576214-28576215(-) m6A exon//intron       24209618
chr17:28614870-28614871(-) m6A 3'UTR//CDS//intron       -
chr17:28614927-28614928(-) m6A 3'UTR//CDS//intron       -
chr17:28618445-28618446(-) m6A 5'UTR//CDS//exon//intron       22575960
chr17:28618488-28618489(-) m6A 5'UTR//CDS//exon//intron       22575960
chr17:28618677-28618678(-) m6A 5'UTR//intron       -
chr17:28618878-28618879(-) m6A 5'UTR//exon//intron       27773536
chr17:28619025-28619026(-) m6A 5'UTR//exon       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate BLMH
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol K562 cells     -
Exosome Blood     -
Insoluble cytoplasm K562 cells     -
Membrane HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: BLMH

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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