Basic Information:

  VIRBase ID:  

VHID00501779

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          ATP6V1A:  NM_001690     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	ATP6V1A
miRBase Accession/Entrez ID	MIMAT0001581	523
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	ARCL2D//ATP6A1//ATP6V1A1//DEE93//HO68//IECEE3//VA68//Vma1//VPP2

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ATP6V1A	chr3:113504517(+) A-I      intronic chr3:113504508(+) A-I      intronic chr3:113504503(+) A-I      intronic chr3:113500233(+) A-I      intronic chr3:113504501(+) A-I      intronic chr3:113504459(+) A-I      intronic chr3:113489373(+) A-I      intronic chr3:113489387(+) A-I      intronic chr3:113500208(+) A-I      intronic chr3:113500211(+) A-I      intronic chr3:113504456(+) A-I      intronic chr3:113500203(+) A-I      intronic chr3:113504468(+) A-I      intronic chr3:113504455(+) A-I      intronic chr3:113484242(+) A-I      intronic chr3:113500199(+) A-I      intronic chr3:113497094(+) A-I      intronic chr3:113497085(+) A-I      intronic chr3:113497080(+) A-I      intronic chr3:113497079(+) A-I      intronic chr3:113494951(+) A-I      intronic chr3:113494950(+) A-I      intronic chr3:113494312(+) A-I      intronic chr3:113493524(+) A-I      intronic chr3:113492046(+) A-I      intronic chr3:113491824(+) A-I      intronic chr3:113490491(+) A-I      intronic chr3:113490466(+) A-I      intronic chr3:113490384(+) A-I      intronic chr3:113489888(+) A-I      intronic chr3:113489784(+) A-I      intronic chr3:113489780(+) A-I      intronic chr3:113489428(+) A-I      intronic chr3:113489376(+) A-I      intronic chr3:113489315(+) A-I      intronic chr3:113489061(+) A-I      intronic chr3:113489021(+) A-I      intronic chr3:113487663(+) A-I      intronic chr3:113487542(+) A-I      intronic chr3:113486722(+) A-I      intronic chr3:113486714(+) A-I      intronic chr3:113486683(+) A-I      intronic chr3:113486674(+) A-I      intronic chr3:113486602(+) A-I      intronic chr3:113485962(+) A-I      intronic chr3:113485380(+) A-I      intronic chr3:113485260(+) A-I      intronic chr3:113485168(+) A-I      intronic chr3:113484699(+) A-I      intronic chr3:113484680(+) A-I      intronic chr3:113484663(+) A-I      intronic chr3:113484654(+) A-I      intronic chr3:113484643(+) A-I      intronic chr3:113484509(+) A-I      intronic chr3:113484291(+) A-I      intronic chr3:113512052(+) A-I      intronic chr3:113519734(+) A-I      intronic chr3:113516809(+) A-I      intronic chr3:113483760(+) A-I      intronic chr3:113483006(+) A-I      intronic chr3:113483000(+) A-I      intronic chr3:113482867(+) A-I      intronic chr3:113482181(+) A-I      intronic chr3:113482173(+) A-I      intronic chr3:113482141(+) A-I      intronic chr3:113482096(+) A-I      intronic chr3:113482080(+) A-I      intronic chr3:113482076(+) A-I      intronic chr3:113482019(+) A-I      intronic chr3:113481295(+) A-I      intronic chr3:113481144(+) A-I      intronic chr3:113516804(+) A-I      intronic chr3:113516332(+) A-I      intronic chr3:113516204(+) A-I      intronic chr3:113515839(+) A-I      intronic chr3:113512090(+) A-I      intronic chr3:113526709(+) A-I      intronic chr3:113509082(+) A-I      intronic chr3:113511958(+) A-I      intronic chr3:113482119(+) A-I      intronic chr3:113526892(+) A-I      intronic chr3:113526870(+) A-I      intronic chr3:113512067(+) A-I      intronic chr3:113512062(+) A-I      intronic chr3:113526862(+) A-I      intronic chr3:113527400(+) A-I      intronic chr3:113526820(+) A-I      intronic chr3:113526801(+) A-I      intronic chr3:113474293(+) A-I      intronic chr3:113504564(+) A-I      intronic chr3:113504495(+) A-I      intronic chr3:113501635(+) A-I      intronic chr3:113526897(+) A-I      intronic chr3:113479984(+) A-I      intronic chr3:113479976(+) A-I      intronic chr3:113479767(+) A-I      intronic chr3:113501564(+) A-I      intronic chr3:113512059(+) A-I      intronic chr3:113479705(+) A-I      intronic chr3:113479704(+) A-I      intronic chr3:113479698(+) A-I      intronic chr3:113508930(+) A-I      intronic chr3:113508921(+) A-I      intronic chr3:113508892(+) A-I      intronic chr3:113508853(+) A-I      intronic chr3:113479388(+) A-I      intronic chr3:113526896(+) A-I      intronic chr3:113501532(+) A-I      intronic chr3:113501494(+) A-I      intronic chr3:113500322(+) A-I      intronic chr3:113500227(+) A-I      intronic chr3:113500217(+) A-I      intronic chr3:113512036(+) A-I      intronic chr3:113528052(+) A-I      intronic chr3:113472682(+) A-I      intronic chr3:113524921(+) A-I      intronic chr3:113524918(+) A-I      intronic chr3:113521695(+) A-I      intronic chr3:113527256(+) A-I      intronic chr3:113527268(+) A-I      intronic chr3:113527321(+) A-I      intronic chr3:113480462(+) A-I      intronic chr3:113480463(+) A-I      intronic chr3:113480486(+) A-I      intronic chr3:113521610(+) A-I      ncRNA chr3:113486039(+) A-I      intronic chr3:113486129(+) A-I      intronic chr3:113491833(+) A-I      intronic chr3:113526120(+) A-I      intronic chr3:113524993(+) A-I      intronic chr3:113489270(+) A-I      intronic chr3:113521397(+) A-I      intronic chr3:113494266(+) A-I      intronic chr3:113480069(+) A-I      intronic chr3:113484361(+) A-I      intronic chr3:113524577(+) A-I      intronic chr3:113508997(+) A-I      intronic chr3:113494298(+) A-I      intronic chr3:113526982(+) A-I      intronic chr3:113491914(+) A-I      intronic chr3:113526966(+) A-I      intronic chr3:113493484(+) A-I      intronic chr3:113519904(+) A-I      intronic chr3:113526929(+) A-I      intronic chr3:113504101(+) A-I      intronic chr3:113484331(+) A-I      intronic chr3:113524964(+) A-I      intronic chr3:113489821(+) A-I      intronic chr3:113515993(+) A-I      intronic chr3:113485217(+) A-I      intronic chr3:113527330(+) A-I      intronic chr3:113495055(+) A-I      intronic chr3:113474380(+) A-I      intronic chr3:113482074(+) A-I      intronic chr3:113493451(+) A-I      intronic chr3:113493462(+) A-I      intronic chr3:113486148(+) A-I      intronic chr3:113495046(+) A-I      intronic chr3:113480359(+) A-I      intronic chr3:113501529(+) A-I      intronic chr3:113489862(+) A-I      intronic chr3:113494177(+) A-I      intronic chr3:113484563(+) A-I      intronic chr3:113516820(+) A-I      intronic chr3:113524555(+) A-I      intronic chr3:113521771(+) A-I      intronic chr3:113494151(+) A-I      intronic chr3:113480050(+) A-I      intronic chr3:113487517(+) A-I      intronic chr3:113516371(+) A-I      intronic chr3:113497121(+) A-I      intronic chr3:113489013(+) A-I      intronic chr3:113504207(+) A-I      intronic chr3:113526816(+) A-I      intronic chr3:113521720(+) A-I      intronic chr3:113509007(+) A-I      intronic chr3:113473274(+) A-I      intronic chr3:113515882(+) A-I      intronic chr3:113489339(+) A-I      intronic chr3:113504040(+) A-I      intronic chr3:113481229(+) A-I      intronic chr3:113474344(+) A-I      intronic chr3:113489405(+) A-I      intronic chr3:113487507(+) A-I      intronic chr3:113497162(+) A-I      intronic chr3:113494357(+) A-I      intronic chr3:113484330(+) A-I      intronic chr3:113493581(+) A-I      intronic chr3:113473269(+) A-I      intronic chr3:113484431(+) A-I      intronic chr3:113516229(+) A-I      intronic chr3:113519849(+) A-I      intronic chr3:113484640(+) A-I      intronic chr3:113482831(+) A-I      intronic chr3:113489778(+) A-I      intronic chr3:113489887(+) A-I      intronic chr3:113486186(+) A-I      intronic chr3:113519844(+) A-I      intronic chr3:113482003(+) A-I      intronic chr3:113479754(+) A-I      intronic chr3:113516833(+) A-I      intronic chr3:113480329(+) A-I      intronic chr3:113519746(+) A-I      intronic chr3:113529163(+) A-I      3'UTR chr3:113485987(+) A-I      intronic chr3:113524840(+) A-I      intronic chr3:113497383(+) A-I      intronic chr3:113483709(+) A-I      intronic chr3:113489269(+) A-I      intronic chr3:113521745(+) A-I      intronic chr3:113486149(+) A-I      intronic chr3:113489310(+) A-I      intronic chr3:113519760(+) A-I      intronic chr3:113496457(+) A-I      intronic chr3:113527361(+) A-I      intronic chr3:113525060(+) A-I      intronic chr3:113485236(+) A-I      intronic chr3:113521356(+) A-I      intronic chr3:113485201(+) A-I      intronic chr3:113494299(+) A-I      intronic chr3:113527910(+) A-I      intronic chr3:113495059(+) A-I      intronic chr3:113489159(+) A-I      intronic chr3:113496466(+) A-I      intronic chr3:113489437(+) A-I      intronic chr3:113486709(+) A-I      intronic chr3:113497345(+) A-I      intronic chr3:113504167(+) A-I      intronic chr3:113500370(+) A-I      intronic chr3:113491987(+) A-I      intronic chr3:113496492(+) A-I      intronic chr3:113500158(+) A-I      intronic chr3:113473327(+) A-I      intronic chr3:113521307(+) A-I      intronic chr3:113516312(+) A-I      intronic chr3:113516760(+) A-I      intronic chr3:113472746(+) A-I      intronic chr3:113497098(+) A-I      intronic chr3:113494216(+) A-I      intronic chr3:113481230(+) A-I      intronic chr3:113519792(+) A-I      intronic chr3:113521396(+) A-I      intronic chr3:113494291(+) A-I      intronic chr3:113493539(+) A-I      intronic chr3:113487572(+) A-I      intronic chr3:113487486(+) A-I      intronic chr3:113485381(+) A-I      intronic chr3:113494324(+) A-I      intronic chr3:113487543(+) A-I      intronic chr3:113497338(+) A-I      intronic chr3:113495172(+) A-I      intronic chr3:113526052(+) A-I      intronic chr3:113481294(+) A-I      intronic chr3:113497031(+) A-I      intronic chr3:113519855(+) A-I      intronic chr3:113482208(+) A-I      intronic chr3:113526167(+) A-I      intronic chr3:113497173(+) A-I      intronic chr3:113496401(+) A-I      intronic chr3:113494181(+) A-I      intronic chr3:113501615(+) A-I      intronic chr3:113519941(+) A-I      intronic chr3:113482927(+) A-I      intronic chr3:113501574(+) A-I      intronic chr3:113496525(+) A-I      intronic chr3:113487626(+) A-I      intronic chr3:113480878(+) A-I      intronic chr3:113474368(+) A-I      intronic chr3:113494339(+) A-I      intronic chr3:113496412(+) A-I      intronic chr3:113479820(+) A-I      intronic chr3:113485416(+) A-I      intronic chr3:113497153(+) A-I      intronic chr3:113482064(+) A-I      intronic chr3:113526046(+) A-I      intronic chr3:113489848(+) A-I      intronic chr3:113489673(+) A-I      intronic chr3:113504616(+) A-I      intronic chr3:113485404(+) A-I      intronic chr3:113486741(+) A-I      intronic chr3:113504183(+) A-I      intronic chr3:113479787(+) A-I      intronic chr3:113486122(+) A-I      intronic chr3:113489403(+) A-I      intronic chr3:113524999(+) A-I      intronic chr3:113481394(+) A-I      intronic chr3:113512172(+) A-I      intronic chr3:113483647(+) A-I      intronic chr3:113495041(+) A-I      intronic chr3:113497189(+) A-I      intronic chr3:113494286(+) A-I      intronic chr3:113479997(+) A-I      intronic chr3:113488970(+) A-I      intronic chr3:113497299(+) A-I      intronic chr3:113497340(+) A-I      intronic chr3:113479365(+) A-I      intronic chr3:113485347(+) A-I      intronic chr3:113504430(+) A-I      intronic chr3:113482982(+) A-I      intronic chr3:113511931(+) A-I      intronic chr3:113494194(+) A-I      intronic chr3:113511981(+) A-I      intronic chr3:113495056(+) A-I      intronic chr3:113482832(+) A-I      intronic chr3:113511986(+) A-I      intronic chr3:113483645(+) A-I      intronic chr3:113485394(+) A-I      intronic chr3:113489791(+) A-I      intronic chr3:113489053(+) A-I      intronic chr3:113489854(+) A-I      intronic chr3:113487584(+) A-I      intronic chr3:113484371(+) A-I      intronic chr3:113497309(+) A-I      intronic chr3:113489035(+) A-I      intronic chr3:113521614(+) A-I      ncRNA

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ATP6V1A	chr3:113472643(+) A-G intron -    22484847 chr3:113473273(+) A-G intron -    22484847 chr3:113473274(+) A-G intron -    22484847 chr3:113474380(+) A-G intron -    22484847 chr3:113479365(+) A-G intron -    22484847 chr3:113479787(+) A-G intron -    22484847 chr3:113479814(+) G-T intron -    22484847 chr3:113479997(+) A-G intron -    22484847 chr3:113481229(+) A-G intron -    22484847 chr3:113481230(+) A-G intron -    22484847 chr3:113481251(+) A-G intron -    22484847 chr3:113482074(+) A-G intron -    22484847 chr3:113482831(+) A-G intron -    22484847 chr3:113482832(+) A-G intron -    22484847 chr3:113484331(+) A-G intron -    22484847 chr3:113484371(+) A-G intron -    22484847 chr3:113484431(+) A-G intron -    22484847 chr3:113484640(+) A-G intron -    22484847 chr3:113485201(+) A-G intron -    22484847 chr3:113485217(+) A-G intron -    22484847 chr3:113485243(+) A-G intron -    22484847 chr3:113485325(+) A-G intron -    22484847 chr3:113485332(+) A-G intron -    22484847 chr3:113485347(+) A-G intron -    22484847 chr3:113485381(+) A-G intron -    22484847 chr3:113485393(+) T-C intron -    22484847 chr3:113485404(+) A-G intron -    22484847 chr3:113485416(+) A-G intron -    22484847 chr3:113485987(+) A-G intron -    22484847 chr3:113486038(+) A-G intron -    22484847 chr3:113486039(+) A-G intron -    22484847 chr3:113486086(+) A-G intron -    22484847 chr3:113486105(+) A-G intron -    22484847 chr3:113486119(+) A-G intron -    22484847 chr3:113486122(+) A-G intron -    22484847 chr3:113486149(+) A-G intron -    22484847 chr3:113486709(+) A-G intron -    22484847 chr3:113487486(+) A-G intron -    22484847 chr3:113487517(+) A-G intron -    22484847 chr3:113487572(+) A-G intron -    22484847 chr3:113487608(+) A-G intron -    22484847 chr3:113488970(+) A-G intron -    22484847 chr3:113488975(+) A-G intron -    22484847 chr3:113489013(+) A-G intron -    22484847 chr3:113489035(+) A-G intron -    22484847 chr3:113489037(+) A-G intron -    22484847 chr3:113489132(+) A-G intron -    22484847 chr3:113489269(+) A-G intron -    22484847 chr3:113489270(+) A-G intron -    22484847 chr3:113489365(+) A-G intron -    22484847 chr3:113489366(+) A-G intron -    22484847 chr3:113489403(+) A-G intron -    22484847 chr3:113489673(+) A-G intron -    22484847 chr3:113489764(+) A-G intron -    22484847 chr3:113489778(+) A-G intron -    22484847 chr3:113489848(+) A-G intron -    22484847 chr3:113489862(+) A-G intron -    22484847 chr3:113491454(+) A-G intron -    22484847 chr3:113491987(+) A-G intron -    22484847 chr3:113493490(+) A-G intron -    22484847 chr3:113493496(+) A-G intron -    22484847 chr3:113493581(+) A-G intron -    22484847 chr3:113494094(+) G-T intron -    22484847 chr3:113494128(+) A-G intron -    22484847 chr3:113494151(+) A-G intron -    22484847 chr3:113494177(+) A-G intron -    22484847 chr3:113494180(+) A-G intron -    22484847 chr3:113494181(+) A-G intron -    22484847 chr3:113494194(+) A-G intron -    22484847 chr3:113494216(+) A-G intron -    22484847 chr3:113494266(+) A-G intron -    22484847 chr3:113494291(+) A-G intron -    22484847 chr3:113494298(+) A-G intron -    22484847 chr3:113494299(+) A-G intron -    22484847 chr3:113496341(+) A-G intron -    22484847 chr3:113496492(+) A-G intron -    22484847 chr3:113497189(+) A-G intron -    22484847 chr3:113501529(+) A-G intron -    22484847 chr3:113501574(+) A-G intron -    22484847 chr3:113501615(+) A-G intron -    22484847 chr3:113504616(+) A-G intron -    22484847 chr3:113504711(+) C-T intron -    22484847 chr3:113508034(+) A-G intron -    22484847 chr3:113511931(+) A-G intron -    22484847 chr3:113511981(+) A-G intron -    22484847 chr3:113515882(+) A-G intron -    22484847 chr3:113515883(+) A-G intron -    22484847 chr3:113516169(+) A-G intron -    22484847 chr3:113516312(+) A-G intron -    22484847 chr3:113521610(+) A-G intron -    22484847 chr3:113526816(+) A-G intron -    22484847 chr3:113527330(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ATP6V1A	chr3:113529285-113529286(+) m6A 3'UTR       27773535 chr3:113530711-113530712(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ATP6V1A	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: ATP6V1A

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.