Basic Information:

  VIRBase ID:  

VHID00501573

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          ALDH1B1:  NM_000692     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	ALDH1B1
miRBase Accession/Entrez ID	MIMAT0001581	219
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	ALDH5//ALDHX

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ALDH1B1	chr9:38392707-38392708(+) m6A 5'UTR       24284625//25456834//24981863//22608085 chr9:38392737-38392738(+) m6A 5'UTR       24284625//25456834//24981863//22608085 chr9:38392757-38392758(+) m6A 5'UTR       24284625//25456834//24981863//22608085 chr9:38392763-38392764(+) m6A 5'UTR       24284625//25456834//24981863//22608085 chr9:38392781-38392782(+) m6A 5'UTR       24284625//25456834//24981863//26404942//22608085 chr9:38394475-38394476(+) m6A 5'UTR//intron       - chr9:38394510-38394511(+) m6A 5'UTR//intron       - chr9:38395790-38395791(+) m6A CDS       24284625//25456834//24981863//26404942//22608085 chr9:38395836-38395837(+) m6A CDS       24284625//24981863//26404942 chr9:38395842-38395843(+) m6A CDS       24284625//24981863//26404942 chr9:38395901-38395902(+) m6A CDS       24284625//24981863//26404942//22575960 chr9:38396061-38396062(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:38396073-38396074(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:38396114-38396115(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:38396121-38396122(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:38396157-38396158(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:38396222-38396223(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:38396301-38396302(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:38396329-38396330(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:38396384-38396385(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:38396451-38396452(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:38396717-38396718(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22608085 chr9:38396759-38396760(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22608085 chr9:38396793-38396794(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:38396808-38396809(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:38396832-38396833(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:38396893-38396894(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:38397105-38397106(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:38397143-38397144(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:38397156-38397157(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:38397291-38397292(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:38397385-38397386(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr9:38397422-38397423(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22575960//22608085 chr9:38397477-38397478(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22575960//22608085 chr9:38397570-38397571(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:38397581-38397582(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:38397623-38397624(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:38397672-38397673(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:38397703-38397704(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:38397754-38397755(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr9:38397899-38397900(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085 chr9:38398017-38398018(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr9:38398026-38398027(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr9:38398043-38398044(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr9:38398072-38398073(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr9:38398128-38398129(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085 chr9:38398220-38398221(+) m6A 3'UTR       24209618//24981863//22608085 chr9:38398260-38398261(+) m6A 3'UTR       24209618//24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ALDH1B1	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: ALDH1B1

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.