Detail Information

Basic Information:


  VIRBase ID:  

VHID00501563

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           AKT2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p AKT2
miRBase
Accession/Entrez ID		 MIMAT0001581 208
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - HIHGHH//PKBB//PKBBETA//PRKBB//RAC-BETA

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR AKT2
chr19:40782405(-) A-I      intronic
chr19:40782442(-) A-I      intronic
chr19:40782441(-) A-I      intronic
chr19:40736767(-) A-I      3'UTR
chr19:40736743(-) A-I      3'UTR
chr19:40736798(-) A-I      3'UTR
chr19:40736802(-) A-I      3'UTR
chr19:40736806(-) A-I      3'UTR
chr19:40782637(-) A-I      intronic
chr19:40782379(-) A-I      intronic
chr19:40788573(-) A-I      intronic
chr19:40782370(-) A-I      intronic
chr19:40782443(-) A-I      intronic
chr19:40782448(-) A-I      intronic
chr19:40782388(-) A-I      intronic
chr19:40782449(-) A-I      intronic
chr19:40782401(-) A-I      intronic
chr19:40782892(-) A-I      intronic
chr19:40782818(-) A-I      intronic
chr19:40782535(-) A-I      intronic
chr19:40782477(-) A-I      intronic
chr19:40782924(-) A-I      intronic
chr19:40782518(-) A-I      intronic
chr19:40781837(-) A-I      intronic
chr19:40782802(-) A-I      intronic
chr19:40782486(-) A-I      intronic
chr19:40782450(-) A-I      intronic
chr19:40746838(-) A-I      intronic
chr19:40782378(-) A-I      intronic
chr19:40746832(-) A-I      intronic
chr19:40760327(-) A-I      intronic
chr19:40782361(-) A-I      intronic
chr19:40782904(-) A-I      intronic
chr19:40760323(-) A-I      intronic
chr19:40781647(-) A-I      intronic
chr19:40781856(-) A-I      intronic
chr19:40781771(-) A-I      intronic
chr19:40760260(-) A-I      intronic
chr19:40736695(-) A-I      3'UTR
chr19:40736809(-) A-I      3'UTR
chr19:40736893(-) A-I      3'UTR
chr19:40736897(-) A-I      3'UTR
chr19:40782718(-) A-I      intronic
chr19:40782886(-) A-I      intronic
chr19:40752236(-) A-I      intronic
chr19:40781820(-) A-I      intronic
chr19:40777271(-) A-I      intronic
chr19:40782358(-) A-I      intronic
chr19:40782880(-) A-I      intronic
chr19:40782678(-) A-I      intronic
chr19:40772847(-) A-I      intronic
chr19:40752152(-) A-I      intronic
chr19:40782808(-) A-I      intronic
chr19:40750239(-) A-I      intronic
chr19:40742713(-) A-I      intronic
chr19:40774960(-) A-I      intronic
chr19:40782451(-) A-I      intronic
chr19:40782437(-) A-I      intronic
chr19:40787304(-) A-I      intronic
chr19:40782562(-) A-I      intronic
chr19:40752226(-) A-I      intronic
chr19:40746848(-) A-I      intronic
chr19:40781836(-) A-I      intronic
chr19:40752304(-) A-I      intronic
chr19:40782500(-) A-I      intronic
chr19:40736902(-) A-I      3'UTR
chr19:40736797(-) A-I      3'UTR
chr19:40782544(-) A-I      intronic
chr19:40782476(-) A-I      intronic
chr19:40782830(-) A-I      intronic
chr19:40736766(-) A-I      3'UTR
chr19:40782550(-) A-I      intronic
chr19:40782657(-) A-I      intronic
chr19:40756206(-) A-I      intronic
chr19:40782908(-) A-I      intronic
chr19:40736811(-) A-I      3'UTR
chr19:40782928(-) A-I      intronic
chr19:40782666(-) A-I      intronic
chr19:40782725(-) A-I      intronic
chr19:40736808(-) A-I      3'UTR
chr19:40787330(-) A-I      intronic
chr19:40736831(-) A-I      3'UTR
chr19:40782552(-) A-I      intronic
chr19:40777215(-) A-I      intronic
chr19:40736730(-) A-I      3'UTR
chr19:40781649(-) A-I      intronic
chr19:40774951(-) A-I      intronic
chr19:40736749(-) A-I      3'UTR
chr19:40787201(-) A-I      intronic
chr19:40781728(-) A-I      intronic
chr19:40736903(-) A-I      3'UTR
chr19:40781859(-) A-I      intronic
chr19:40756248(-) A-I      intronic
chr19:40756374(-) A-I      intronic
chr19:40782896(-) A-I      intronic
chr19:40782340(-) A-I      intronic
chr19:40742818(-) A-I      intronic
chr19:40782333(-) A-I      intronic
chr19:40774861(-) A-I      intronic
chr19:40781740(-) A-I      intronic
chr19:40782756(-) A-I      intronic
chr19:40778994(-) A-I      intronic
chr19:40782446(-) A-I      intronic
chr19:40742831(-) A-I      intronic
chr19:40782648(-) A-I      intronic
chr19:40760709(-) A-I      intronic
chr19:40782731(-) A-I      intronic
chr19:40782452(-) A-I      intronic
chr19:40782679(-) A-I      intronic
chr19:40776868(-) A-I      intronic
chr19:40746815(-) A-I      intronic
chr19:40782410(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED AKT2
chr19:40736725(-) A-G exon 3'UTR    22484847
chr19:40782410(-) A-G intron -    22484847
chr19:40782413(-) A-G intron -    22484847
chr19:40782437(-) A-G intron -    22484847
chr19:40782446(-) A-G intron -    22484847
chr19:40782476(-) A-G intron -    22484847
chr19:40782492(-) A-G intron -    22484847
chr19:40782550(-) A-G intron -    22484847
chr19:40782688(-) A-G intron -    22484847
chr19:40782725(-) A-G intron -    22484847
chr19:40782830(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase AKT2
chr19:40737702-40737703(-) Y 3'UTR       26075521
chr19:40737942-40737943(-) m6A 3'UTR       24981863
chr19:40737993-40737994(-) m6A 3'UTR       -
chr19:40737999-40738000(-) m6A 3'UTR       -
chr19:40738174-40738175(-) m6A 3'UTR       -
chr19:40738240-40738241(-) m6A 3'UTR       27773535
chr19:40738253-40738254(-) m6A 3'UTR//exon       27773535
chr19:40738679-40738680(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535
chr19:40738698-40738699(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535
chr19:40738730-40738731(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535
chr19:40738864-40738865(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//22608085
chr19:40738883-40738884(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//22608085
chr19:40738987-40738988(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//22575960//22608085
chr19:40739053-40739054(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr19:40739067-40739068(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22608085
chr19:40739099-40739100(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr19:40739153-40739154(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22608085
chr19:40739359-40739360(-) m6A 3'UTR//exon       24284625//25456834//24981863//27371828//22575960
chr19:40739555-40739556(-) m6A 3'UTR//exon       24284625//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr19:40739570-40739571(-) m6A 3'UTR//exon       24284625//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr19:40739822-40739823(-) m6A 3'UTR//CDS//exon       24284625//27773535
chr19:40739830-40739831(-) m6A 3'UTR//CDS//exon       24284625//27773535
chr19:40740379-40740380(-) m6A 3'UTR//intron       24284625//27773535
chr19:40741036-40741037(-) m6A 3'UTR//CDS//exon       24284625//27773535//27773536
chr19:40743095-40743096(-) m6A exon//intron       -
chr19:40743122-40743123(-) m6A exon//intron       -
chr19:40743144-40743145(-) m6A exon//intron       -
chr19:40743188-40743189(-) m6A exon//intron       -
chr19:40744858-40744859(-) m6A 3'UTR//CDS//exon//intron       27773535
chr19:40745211-40745212(-) m6A exon//intron       -
chr19:40745292-40745293(-) m6A exon//intron       -
chr19:40745324-40745325(-) m6A exon//intron       -
chr19:40745973-40745974(-) m6A 3'UTR//CDS//exon//intron       27371828//27773536
chr19:40746720-40746721(-) m6A exon//intron       27371828//27773536
chr19:40747933-40747934(-) m6A 3'UTR//CDS//exon       28052920//27371828
chr19:40747949-40747950(-) m6A 3'UTR//CDS//exon       28052920//27371828
chr19:40747975-40747976(-) m6A 3'UTR//CDS//exon       28052920//27371828
chr19:40748519-40748520(-) m6A 3'UTR//CDS//exon       24284625//26404942//27371828//27773536
chr19:40748528-40748529(-) m6A 3'UTR//CDS//exon       24284625//26404942//27371828//27773536
chr19:40748615-40748616(-) m6A exon//intron       24284625//27371828//27773536
chr19:40748631-40748632(-) m6A exon//intron       24284625//27371828//27773536
chr19:40761092-40761093(-) m6A CDS//exon       24284625//24981863
chr19:40761110-40761111(-) m6A CDS//exon       24284625//24981863//27773535
chr19:40761158-40761159(-) m6A CDS//exon       24284625//24981863//27773535
chr19:40762849-40762850(-) m6A 5'UTR//CDS//exon       24284625//27773535
chr19:40762865-40762866(-) m6A 5'UTR//CDS//exon       24284625//27773535
chr19:40762946-40762947(-) m6A 5'UTR//CDS//exon       27773535
chr19:40785096-40785097(-) m6A 5'UTR//exon//intron       27773536
chr19:40785123-40785124(-) m6A 5'UTR//exon//intron       27773536
chr19:40785184-40785185(-) m6A 5'UTR//exon//intron       27773536
chr19:40785253-40785254(-) m6A 5'UTR//intron       27773536
chr19:40785269-40785270(-) m6A 5'UTR//intron       27773536
chr19:40785306-40785307(-) m6A 5'UTR//intron       27773536
chr19:40785423-40785424(-) m6A 5'UTR//intron       27773536
chr19:40785447-40785448(-) m6A 5'UTR//intron       27773536
chr19:40790803-40790804(-) m6A 5'UTR//intron       25456834//24981863//27773536
chr19:40790983-40790984(-) m6A 5'UTR//intron       24209618//27773536
chr19:40791154-40791155(-) m6A 5'UTR//intron       24209618//24981863
chr19:40791169-40791170(-) m6A 5'UTR//intron       24209618//24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate AKT2
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HeLa-S3 cells|K562 cells     -
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: AKT2

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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