Detail Information

Basic Information:


  VIRBase ID:  

VHID00501489

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7951

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           ADCY1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p ADCY1
miRBase
Accession/Entrez ID		 MIMAT0001581 107
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - AC1//DFNB44

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ADCY1
chr7:45737067(+) A-I      intronic
chr7:45737015(+) A-I      intronic
chr7:45676239(+) A-I      intronic
chr7:45737163(+) A-I      intronic
chr7:45737090(+) A-I      intronic
chr7:45760036(+) A-I      3'UTR
chr7:45760017(+) A-I      3'UTR
chr7:45677106(+) A-I      intronic
chr7:45677230(+) A-I      intronic
chr7:45676240(+) A-I      intronic
chr7:45735891(+) A-I      intronic
chr7:45760016(+) A-I      3'UTR
chr7:45677067(+) A-I      intronic
chr7:45677156(+) A-I      intronic
chr7:45677279(+) A-I      intronic
chr7:45677203(+) A-I      intronic
chr7:45655123(+) A-I      intronic
chr7:45737116(+) A-I      intronic
chr7:45737129(+) A-I      intronic
chr7:45677270(+) A-I      intronic
chr7:45676214(+) A-I      intronic
chr7:45660927(+) A-I      intronic
chr7:45625213(+) A-I      intronic
chr7:45660745(+) A-I      intronic
chr7:45677111(+) A-I      intronic
chr7:45735871(+) A-I      intronic
chr7:45677139(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ADCY1
chr7:45676240(+) A-G intron -    22484847
chr7:45677060(+) A-G intron -    22484847
chr7:45677106(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ADCY1
chr7:45726234-45726235(+) m6A CDS       24981863
chr7:45726252-45726253(+) m6A CDS       24981863
chr7:45742993-45742994(+) m6A CDS       24981863
chr7:45743014-45743015(+) m6A CDS       24981863
chr7:45753405-45753406(+) m6A CDS       25456834//24981863
chr7:45753675-45753676(+) m6A 3'UTR       25456834//24981863//22608085
chr7:45753684-45753685(+) m6A 3'UTR       25456834//24981863//22608085
chr7:45753803-45753804(+) m6A 3'UTR       24209618//25456834//24981863//22575960//22608085
chr7:45753934-45753935(+) m6A 3'UTR       25456834//24981863//22608085
chr7:45754024-45754025(+) m6A 3'UTR       25456834//24981863//22608085
chr7:45754052-45754053(+) m6A 3'UTR       25456834//24981863//22608085
chr7:45754186-45754187(+) m6A 3'UTR       25456834//24981863//22608085
chr7:45754191-45754192(+) m6A 3'UTR       25456834//24981863//22608085
chr7:45754404-45754405(+) m6A 3'UTR       25456834//24981863
chr7:45754412-45754413(+) m6A 3'UTR       25456834//24981863
chr7:45754604-45754605(+) m6A 3'UTR       24981863//22608085
chr7:45754825-45754826(+) m6A 3'UTR       25456834//24981863//22608085
chr7:45754846-45754847(+) m6A 3'UTR       25456834//24981863//22608085
chr7:45754933-45754934(+) m6A 3'UTR       25456834//24981863//22608085
chr7:45754972-45754973(+) m6A 3'UTR       25456834//24981863//22608085
chr7:45756333-45756334(+) m6A 3'UTR       25456834//22608085
chr7:45756379-45756380(+) m6A 3'UTR       25456834//22608085
chr7:45756491-45756492(+) m6A 3'UTR       25456834//24981863//22575960//22608085
chr7:45756685-45756686(+) m6A 3'UTR       25456834//24981863//22575960//22608085
chr7:45756814-45756815(+) m6A 3'UTR       24209618//25456834//24981863//22575960//22608085
chr7:45756855-45756856(+) m6A 3'UTR       25456834//24981863//22575960//22608085
chr7:45756867-45756868(+) m6A 3'UTR       25456834//24981863//22575960//22608085
chr7:45756896-45756897(+) m6A 3'UTR       25456834//24981863//22575960//22608085
chr7:45756921-45756922(+) m6A 3'UTR       25456834//24981863//22575960//22608085
chr7:45756949-45756950(+) m6A 3'UTR       25456834//24981863//22608085
chr7:45756989-45756990(+) m6A 3'UTR       25456834//24981863//22608085
chr7:45757015-45757016(+) m6A 3'UTR       24981863//22608085
chr7:45757395-45757396(+) m6A 3'UTR       24981863
chr7:45757431-45757432(+) m6A 3'UTR       24981863
chr7:45757457-45757458(+) m6A 3'UTR       24981863
chr7:45758321-45758322(+) m6A 3'UTR       25456834
chr7:45758338-45758339(+) m6A 3'UTR       25456834
chr7:45758415-45758416(+) m6A 3'UTR       25456834
chr7:45759794-45759795(+) m6A 3'UTR       24981863
chr7:45759804-45759805(+) m6A 3'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate ADCY1
Chromatin K562 cells     -
Exosome Blood     -

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: ADCY1

Evidence Support:


Strong-Evidence RISC-IP
Prediction-Evidence cRep//miRanda//PITA
Support Database RepTar//ViRBase//VmiReg

References:


PMID 20585629 Target region 5'UTR
Source RepTar//ViRBase//VmiReg Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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