Basic Information:

  VIRBase ID:  

VHID00501335

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          LINC00999:  NR_024497     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	LINC00999
miRBase Accession/Entrez ID	MIMAT0001581	399744
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	lncRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt	PMID
LincSNP 3.0	LINC00999	rs2804649 chr10:38448326 C/T         17873874

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	LINC00999	chr10:38717083(+) A-I      ncRNA chr10:38729112(+) A-I      intronic chr10:38728857(+) A-I      intronic chr10:38721674(+) A-I      intronic chr10:38718218(+) A-I      intronic chr10:38732340(+) A-I      intronic chr10:38729364(+) A-I      intronic chr10:38721607(+) A-I      intronic chr10:38721593(+) A-I      intronic chr10:38721547(+) A-I      intronic chr10:38730490(+) A-I      intronic chr10:38721542(+) A-I      intronic chr10:38728955(+) A-I      intronic chr10:38721047(+) A-I      intronic chr10:38720964(+) A-I      intronic chr10:38720943(+) A-I      intronic chr10:38719960(+) A-I      intronic chr10:38718134(+) A-I      intronic chr10:38718124(+) A-I      intronic chr10:38718107(+) A-I      intronic chr10:38729358(+) A-I      intronic chr10:38719982(+) A-I      intronic chr10:38733097(+) A-I      intronic chr10:38729356(+) A-I      intronic chr10:38729257(+) A-I      intronic chr10:38729223(+) A-I      intronic chr10:38724116(+) A-I      ncRNA chr10:38719989(+) A-I      intronic chr10:38719976(+) A-I      intronic chr10:38718235(+) A-I      intronic chr10:38734879(+) A-I      intronic chr10:38724235(+) A-I      intronic chr10:38717661(+) A-I      intronic chr10:38717691(+) A-I      intronic chr10:38729005(+) A-I      intronic chr10:38721597(+) A-I      intronic chr10:38722808(+) A-I      intronic chr10:38722846(+) A-I      intronic chr10:38729365(+) A-I      intronic chr10:38720023(+) A-I      intronic chr10:38717662(+) A-I      intronic chr10:38733061(+) A-I      intronic chr10:38735662(+) A-I      intronic chr10:38730469(+) A-I      intronic chr10:38724230(+) A-I      intronic chr10:38720022(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	LINC00999	chr10:38736615-38736616(+) m6A 3'UTR       24981863 chr10:38736775-38736776(+) m6A 3'UTR       24981863 chr10:38736799-38736800(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	LINC00999	Nucleoplasm K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	LINC00999	2-(((5-(4-(4-(3-Fluorobenzyloxy)-3-chlorophenylamino)quinazolin-6-yl)furan-2-yl)methyl)(2-(methylsulfonyl)ethyl)amino)acetonitrile       9873849 9H-Purine, 6-(ethylthio)-9-beta-D-ribofuranosyl-(8CI)(9CI)       95846 6-Benzylthioinosine       95263 Tiotixene       941651 Acridine Yellow G       8672 Sulfonaphtholazoresorcinol       85517 Benzethonium chloride       8478 3-Hydroxy-4-(phenylazo)-2-naphthoic acid       80753 3-Amino-7-(dimethylamino)-5-phenylphenazinium chloride       75442 Cyclopentenyl cytosine       72828 Panobinostat       6918837 Brigatinib       68165256 Triciribine       65399 2-Pyridinecarboxaldehyde, 2-quinolinylhydrazone       6436860 Phylanthoside       6436218 Citreoviridin       6436023 4-(N-Hydroxyacetamido)stilbene       6433723 Irinotecan       60838 Topotecan       60700 5-[2-[4-(Aminomethyl)phenyl]-5-pyridin-4-yl-1H-imidazol-4-yl]-2-chlorophenol;hydrochloride       57399803 l-685,458       5479543 Phyllanthastatin 1       5477587 3-Bromo-4-N,N-bis-2'-cyanoethylaminobenzylidene rhodanine       5469596 Viridenomycin       54686463 Mito-tempol       54613387 Olivomycin Transformation       54610760 Eupalmerin acetate       5459169 Sulfaquinoxaline       5338 Palbociclib       5330286 N-(2-Methoxyphenyl)-5-phenyl-1,3-oxazol-2-amine       5329844 Alsterpaullone       5005498 Dichloroplatinum; 2-(4-methoxyphenyl)ethanamine       498558 Okadaic acid       446512 Ouabain       439501 Cinerubin A hydrochloride       428786 Vemurafenib       42611257 Ptilomycalin A format salt       395755 6-(Benzyloxy)-5-bromo-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one       376767 1,2,4,5-Tetrazine, 3,6-bis(1-azetidinyl)-       362170 4-Methyl-2-{2-[(pyridin-2-yl)methylidene]hydrazin-1-yl}quinoline       332903 4-(3,12-Dihydroxy-10,13-dimethyl-7-oxo-1,2,3,4,5,6,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl)pentanoic acid       302 AT 116, benzylamine salt       282523 2-(6-Phenanthridinylthio)-1-phenylethanone       264067 6-Chloro-2-methoxy-9-[(5-piperidinopentyl)amino]acridine       219600 Sorafenib       216239 8-Amino-5-methyl-6-phenylphenanthridin-5-ium bromide       21144180 Kinetin riboside       20345 8-Chloro-cyclicamp       17856967 Mercury, (acetyloxy)(pentamethylphenyl)-       16683786 5-Chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidine-2,4-diamine       16038120 8-Chloroadenosine       147569 Homidium bromide       14710 Basic violet 2       14454445 Berberine chloride       12456 (Z)-But-2-enedioic acid;3-[4-[(3Z)-3-(2-chlorothioxanthen-9-ylidene)propyl]piperazin-1-yl]-N-methylpropanamide       11954261 Crizotinib       11626560 Pararosaniline hydrochloride       11292 Setoglaucine       107404 Pha-665752       10461815 25-Dihydrosaframycin A       100180 9-(2-Amino-2-deoxy-d-xylofuranosyl) adenine       100053 1,4-dimethoxy-7-azaisoindole[2,1-a]quinoxalin-6(5h)-one       - ;(1R,6S,11aS,13S,14aR)-6-ethyl-1,13-dihydroxy-1,6,7,8,9,...       - 5,6-ethylenediquino[3,2-b       - .alpha.-sarcin       - Basic Fuchsin       - benzo[1,2-b:5,4-b']dithiophene-4,8-dione, 3-methyl-       - benzo[b]naphtho[2,3-d]furan-6,11-dione, 4-chloro-3-hydroxy       - crotoxin cd       - gramicidin       - hydroxyprogesterone caproate (usan)       - naphth[2,3-d]oxazol-9-one, 2-methyl-4-(phenylimino)-       - naphtho[2,1-b]quinolizinium, 5-chloro-7-methyl- perchlorate       - naphtho[2,3-b]furan-4,9-dione, 2-bromo-       - N-methyl-N-(4-(3-(pyrrolidin-1-yl)propoxy)benzyl)-4-(2,6...       - pararosaniline pamoate       - protein toxin a 23 - mw approx. 6700       - protein toxin c 10 - mw approx. 6700       - riboprine(usan)       - tp38-279       - Tyrothricin       -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: LINC00999

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.