Basic Information:

  VIRBase ID:  

VHID00501154

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Rattus norvegicus

  Confidence Score:  

0.9526

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-1-5p:  MIMAT0002182          Nfkbia:  NM_001105720     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-1-5p	Nfkbia
miRBase Accession/Entrez ID	MIMAT0002182	25493
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Rattus norvegicus
Category	miRNA	mRNA
Alias	-	RL/IF-1

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-1-5p
Interactor2: Nfkbia

Evidence Support:

Strong-Evidence	IFA//Luciferase reporter assay//RT-PCR
Support Database	VmiReg

References:

PMID	24385912	Target region	None
Source	VmiReg	Interactor1 expression	None
Tissue or cell line	WT cells	Interactor2 expression	None
Description	Mutation of the putative targeting site abolished the repressive effect of miR-K1. In WT cells, a miR-K1 suppressor increased the IkaapaBalpha 3UTR reporter activity by 1.6-fold but had no effect on the mutant 3'UTR reporter activity (Fig. 6D). Together, these results indicated that, similar to human IkaapaBalpha, rat IkaapaBalpha was also a target of KSHV miR-K1.