Detail Information

Basic Information:


  VIRBase ID:  

VHID00501147

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Mus musculus

  Confidence Score:  

0.9639

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-10b:           Bclaf1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol kshv-miR-K12-10b Bclaf1
miRBase
Accession/Entrez ID		 MIMAT0002180 72567
Organism Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV) Mus musculus
Category miRNA mRNA
Alias - 2610102K23Rik//2700025J07Rik//2810454G14Rik//5730534O06Rik//AI450190//AW556225//Btf//mKIAA0164

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR Bclaf1
chr10:20038308(+) A-I      intronic
chr10:20056015(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED Bclaf1
chr10:20336209(+) A-I intron -    22524474

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase Bclaf1
chr10:20312571-20312572(+) m6A 5'UTR//exon       24981863//25569111//22608085
chr10:20318075-20318076(+) m6A 5'UTR//exon       24981863//22608085
chr10:20322981-20322982(+) m6A CDS       24981863//22608085
chr10:20323139-20323140(+) m6A CDS       24981863
chr10:20323349-20323350(+) m6A CDS       24981863//25569111
chr10:20323373-20323374(+) m6A CDS       24981863//25569111
chr10:20323415-20323416(+) m6A CDS       24981863//25569111
chr10:20323433-20323434(+) m6A CDS       24981863
chr10:20323764-20323765(+) m6A CDS       25683224//25412662//24981863//25569111//22608085
chr10:20323839-20323840(+) m6A CDS       25683224//25412662//24981863
chr10:20323848-20323849(+) m6A CDS       25683224//25412662//24981863
chr10:20325295-20325296(+) m6A CDS       25683224//25456834//25412662//24981863//25569111//22608085
chr10:20325335-20325336(+) m6A CDS       25683224//25456834//25412662//24981863//25569111//22608085
chr10:20325349-20325350(+) m6A CDS       25683224//25456834//25412662//24981863//25569111//22608085
chr10:20325427-20325428(+) m6A CDS       25683224//25456834//24981863//25569111//22608085
chr10:20325502-20325503(+) m6A CDS       25683224//25456834//24981863//25569111//22608085
chr10:20325512-20325513(+) m6A CDS       25683224//25456834//24981863//25569111//22608085
chr10:20325549-20325550(+) m6A CDS       25683224//25456834//24981863//25569111//22608085
chr10:20325567-20325568(+) m6A CDS       25683224//25456834//25412662//24981863//25569111//22608085
chr10:20325766-20325767(+) m6A CDS       25412662//24981863
chr10:20325949-20325950(+) m6A CDS       25412662//22608085
chr10:20327370-20327371(+) m6A 3'UTR//intron       24981863
chr10:20328171-20328172(+) m6A 3'UTR//CDS       24981863
chr10:20329164-20329165(+) m6A exon//intron       24981863
chr10:20329261-20329262(+) m6A exon//intron       24981863
chr10:20332217-20332218(+) m6A 3'UTR//CDS//exon       25683224//24981863
chr10:20332243-20332244(+) m6A 3'UTR//CDS//exon       25683224//24981863
chr10:20332370-20332371(+) m6A exon//intron       25683224
chr10:20333335-20333336(+) m6A exon//intron       24981863
chr10:20333365-20333366(+) m6A exon//intron       24981863
chr10:20333394-20333395(+) m6A 3'UTR//CDS//exon       24981863
chr10:20333414-20333415(+) m6A 3'UTR//CDS//exon       24981863
chr10:20333509-20333510(+) m6A 3'UTR//CDS//exon       24981863
chr10:20333528-20333529(+) m6A 3'UTR//CDS//exon       24981863
chr10:20333556-20333557(+) m6A 3'UTR//CDS//exon       24981863
chr10:20333566-20333567(+) m6A 3'UTR//CDS//exon       24981863
chr10:20333619-20333620(+) m6A exon//intron       25412662//24981863
chr10:20333635-20333636(+) m6A exon//intron       25412662//24981863
chr10:20333851-20333852(+) m6A exon//intron       24981863
chr10:20334543-20334544(+) m6A CDS//exon//intron       24981863
chr10:20334559-20334560(+) m6A CDS//exon//intron       24981863
chr10:20334587-20334588(+) m6A CDS//exon//intron       24981863
chr10:20339825-20339826(+) m6A 3'UTR//CDS//exon       25412662//24981863//25456834//25569111
chr10:20339873-20339874(+) m6A 3'UTR//CDS//exon       25412662//24981863//25456834//25569111
chr10:20339901-20339902(+) m6A 3'UTR//CDS//exon       25412662//24981863//25456834//25569111
chr10:20340082-20340083(+) m6A 3'UTR//exon       25412662//24981863//25456834//25569111
chr10:20340105-20340106(+) m6A 3'UTR//exon       25412662//24981863//25456834
chr10:20340149-20340150(+) m6A 3'UTR//exon//intron       24981863
chr10:20340581-20340582(+) m6A 3'UTR//intron       24981863
chr10:20340602-20340603(+) m6A 3'UTR//intron       24981863
chr10:20340613-20340614(+) m6A 3'UTR//intron       24981863
chr10:20340683-20340684(+) m6A 3'UTR//intron       24981863//25569111
chr10:20340711-20340712(+) m6A 3'UTR//intron       24981863//25569111
chr10:20340988-20340989(+) m6A 3'UTR//intron       22608085
chr10:20342422-20342423(+) m6A 3'UTR//intron       24981863
chr10:20342456-20342457(+) m6A 3'UTR//intron       24981863
chr10:20344385-20344386(+) m6A 3'UTR       25683224//24981863
chr10:20344416-20344417(+) m6A 3'UTR       25683224//24981863
chr10:20344450-20344451(+) m6A 3'UTR       25683224//24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate Bclaf1
Nucleus Neuroblastoma cell line (N2A)     22406755
Nucleus Neuroblastoma cell line (N2A)     22406755
Nucleus Neuroblastoma cell line (N2A)     22406755

Interaction Network (The top 100 interactions):


Interactor1: kshv-miR-K12-10b
Interactor2: Bclaf1

Evidence Support:


Strong-Evidence Luciferase reporter assay//RT-PCR//Western blot
Prediction-Evidence miRanda//PicTar//Targetscan
Support Database ViRBase

References:


[1]PMID 19098914 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line 293 cells//BCBL-1 cells//BCBL-3 cells//BJAB cells//HUVECs Interactor2 expression Downregulation
Description Indicate miR-K12-5, miR-K12-9 and miR-K12-10 repression of Bcl-2-associated transcription factor 1, an apoptosis-inducing factor.
[2]PMID 21152115 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line 293 cells//BCBL-1 cells//BCBL-3 cells//BJAB cells//HUVECs Interactor2 expression Downregulation
Description More studies from recent reports indicate miR-K12-5, miR-K12-9 and miR-K12-10 repression of Bcl-2-associated transcription factor 1, an apoptosis-inducing factor (238), miR-K12-3 reduction of LRRC8D (leucine rich repeat containing 8 family, member D), a leucin-rich type III transmembrane protein involved in proliferation and activation of lymphocytes, NHP2L1 (non-histone chromosome protein 2-like 1) (239), and a transcription factor NFIB (240), miR-K12-1 inhibition of p21 241 and NFkappaB inhibitor IkappaBalpha (242), miR-K12-4-3p suppression of GEMIN8 (239), miR-K12-10a reduction of TWEAKR (243), miR-K12-1, -6, and -11 decrease of MAF (musculoaponeurotic fibrosarcoma oncogene homolog) (244), K12-4-5p targeting retinoblastoma (Rb)-like protein 2 (Rbl2) and miR-K12-5 and -9*suppressing ORF50 mRNA (245,246).

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